Glomerular filtration rate of black african people: what concordance between MDRD and Cockroft-gault formulas in old and obese poeple

The prevalence of kidney failure is increasing and also affects developing countries. In Africa particularly in Ivory Coast, in the absence of data on the Modification of Diet in Renal Disease formula (MDRD), using the Cockcroft-Gault formula (CG) is still valid for estimating renal function, regardless of the epidemiological and clinical context. The present study aims to compare the CG and MDRD formulas in the diagnosis of chronic renal failure in black Africans subjects.The study involved 470 adult black Africans. Serum creatinine was measured by colorimetric Jaffe method and the formula is the MDRD with 4 variables. Analysis of the collected data was mainly carried out with the EXCEL 2003 software and EPI info 6.04. The comparison is made by a concordance study from the kappa test.The results showed that in the men and women there is no difference between the DFG given by the two formulas (P <0,001); diagnostics agree significantly. However, there is a discrepancy between the results given by both MDRD and CG formulas in the elderly over 65 years ( P = 0,363) and in in Obese subjects ( P = 0,142 ) .Our results show that the choice of the GFR determination method should be based on context. So it becomes imperative to validate the MDRD method among black Africans in order to have more methods of determinations, and then choose the most suitable according to the clinical case for the diagnosis, classification and monitoring of CKD patients

Measured (and estimated) glomerular filtration rate: reference values in West Africa.

peer reviewedBackground: Establishment of normal reference values for glomerular filtration rate (GFR) is mandatory in nephrology. However, no data are available for measured GFR (mGFR) in Africa. Methods: GFR was measured in 237 healthy adult subjects (103 women and 134 men, mean age 34 +/- 10 years) by iohexol plasma clearance. Results: The mean mGFR was 103 +/- 17 mL/min/1.73 m 2 and the median value was 103 mL/min/1.73 m 2 (2.5th and 97.5th percentiles are 76 and 137 mL/min/1.73 m 2 , respectively). No significant difference in mGFR results was observed in patients < 40 years of age, whereas a significant decline in mGFR was observed after 40 years of age. There was no significant difference between mGFR in men and women. Conclusions: Normal GFR values and descriptions of percentiles are now available for West Africa. As in Caucasians, no significant difference was observed between men and women. Moreover, the same age-associated decline in mGFR is also observed after 40 years of age, as in Caucasians