Physician Perceptions on Cancer Screening for LGBTQ+ Patients

The LGBTQ+ community experiences cancer disparities due to increased risk factors and lower screening rates, attributable to health literacy gaps and systemic barriers. We sought to understand the experiences, perceptions, and knowledge base of healthcare providers regarding cancer screening for LGBTQ+ patients. A 20-item IRB-approved survey was distributed to physicians through professional organizations. The survey assessed experiences and education regarding the LGBTQ+ community and perceptions of patient concerns with different cancer screenings on a 5-point Likert scale. Complete responses were collected from 355 providers. Only 100 (28%) reported past LGBTQ+-related training and were more likely to be female (p = 0.020), have under ten years of practice (p = 0.014), or practice family/internal medicine (p \u3c 0.001). Most (85%) recognized that LGBTQ+ subpopulations experience nuanced health issues, but only 46% confidently understood them, and 71% agreed their clinics would benefit from training. Family/internal medicine practitioners affirmed the clinical relevance of patients’ sexual orientation (94%; 62% for medical/radiation oncology). Prior training affected belief in the importance of sexual orientation (p \u3c 0.001), confidence in understanding LGBTQ+ health concerns (p \u3c 0.001), and willingness to be listed as “LGBTQ+-friendly” (p = 0.005). Our study suggests that despite a paucity of formal training, most providers acknowledge that LGBTQ+ patients have unique health needs. Respondents had a lack of consensus regarding cancer screenings for lesbian and transgender patients, indicating the need for clearer screening standards for LGBTQ+ subpopulations and educational programs for providers

Pulmonary intravascular lymphoma diagnosed by 18-fluorodeoxyglucose positron emission tomography-guided transbronchial lung biopsy in a man with long-term survival: a case report

<p>Abstract</p> <p>Introduction</p> <p>18-Fluorodeoxyglucose positron emission tomography can detect the pulmonary involvement of intravascular lymphoma that presents no abnormality in a computed tomography scan.</p> <p>Case presentation</p> <p>We report the case of a 61-year-old Japanese man who had pulmonary intravascular lymphoma and no computed tomography abnormality. We were able to make an antemortem diagnosis of pulmonary intravascular lymphoma by transbronchial lung biopsy according to 18-fluorodeoxyglucose positron emission tomography findings. He is free of recurrent disease 24 months after chemotherapy.</p> <p>Conclusions</p> <p>To the best of our knowledge, this is the first reported case of a long-term survivor of pulmonary intravascular lymphoma diagnosed by transbronchial lung biopsy under the guide of 18-fluorodeoxyglucose positron emission tomography.</p

Defect of Interferon γ Leads to Impaired Wound Healing through Prolonged Neutrophilic Inflammatory Response and Enhanced MMP-2 Activation.

Interferon (IFN)-&gamma; is mainly secreted by CD4+ T helper 1 (Th1), natural killer (NK) and NKT cells after skin injury. Although IFN-&gamma; is well known regarding its inhibitory effects on collagen synthesis by fibroblasts in vitro, information is limited regarding its role in wound healing in vivo. In the present study, we analyzed how the defect of IFN-&gamma; affects wound healing. Full-thickness wounds were created on the backs of wild type (WT) C57BL/6 and IFN-&gamma;-deficient (KO) mice. We analyzed the percent wound closure, wound breaking strength, accumulation of leukocytes, and expression levels of COL1A1, COL3A1, and matrix metalloproteinases (MMPs). IFN-&gamma;KO mice exhibited significant attenuation in wound closure on Day 10 and wound breaking strength on Day 14 after wound creation, characteristics that are associated with prolonged neutrophil accumulation. Expression levels of COL1A1 and COL3A1 mRNA were lower in IFN-&gamma;KO than in WT mice, whereas expression levels of MMP-2 (gelatinase) mRNA were significantly greater in IFN-&gamma;KO than in WT mice. Moreover, under neutropenic conditions created with anti-Gr-1 monoclonal antibodies, wound closure in IFN-&gamma;KO mice was recovered through low MMP-2 expression levels. These results suggest that IFN-&gamma; may be involved in the proliferation and maturation stages of wound healing through the regulation of neutrophilic inflammatory responses

Randomized controlled trial of daily teriparatide, weekly high-dose teriparatide, or bisphosphonate in patients with postmenopausal osteoporosis: The TERABIT study

Purpose: The effects of daily teriparatide (20 μg) (D-PTH), weekly high-dose teriparatide (56.5 μg) (W-PTH), or bisphosphonates (BPs) on areal bone mineral density (aBMD), bone turnover markers (BTMs), volumetric BMD (vBMD), microarchitecture, and estimated strength were investigated in postmenopausal osteoporosis patients.Methods: The study participants were 131 women with a history of fragility fractures. They were randomized to receive D-PTH, W-PTH, or BPs (alendronate or risedronate) for 18 months. Dual-energy X-ray absorptiometry (DXA), BTMs, and high-resolution peripheral quantitative CT (HR-pQCT) parameters were evaluated at baseline and after 6 and 18 months of treatment. The primary endpoint was the change (%) in cortical thickness (Ct.Th) after 18 months\u27 treatment compared with baseline.Results: DXA showed that D-PTH, W-PTH, and BPs increased lumbar spine aBMD (+12.0%, +8.5%, and +6.8%) and total hip aBMD (+3.0%, +2.1%, and +3.0%), but D-PTH and W-PTH decreased 1/3 radius aBMD (− 4.1%, − 3.0%, − 1.4%) after 18 months. On HR-pQCT, D-PTH increased trabecular vBMD (Tb.vBMD) at the distal radius and tibia after 18 months (+6.4%, +3.7%) compared with the BPs group, decreased cortical volumetric tissue mineral density (Ct.vTMD) (− 1.8%, − 0.9%) compared with the other groups, increased Ct.Th (+1.3%, +3.9%), and increased failure load (FL) (+4.7%, +4.4%). W-PTH increased Tb.vBMD (+5.3%, +1.9%), maintained Ct.vTMD (− 0.7%, +0.2%) compared with D-PTH, increased Ct.Th (+0.6%, +3.6%), and increased FL (+4.9%, +4.5%). The BPs increased Tb.vBMD only in the radius (+2.0%, +0.2%), maintained Ct.vTMD (− 0.6%, +0.3%), increased Ct.Th (+0.5%, +3.4%), and increased FL (+3.9%, +2.8%).Conclusions: D-PTH and W-PTH comparably increased Ct.Th, the primary endpoint. D-PTH had a strong effect on trabecular bone. Although D-PTH decreased Ct.vTMD, it increased Ct.Th and total bone strength. W-PTH had a moderate effect on trabecular bone, maintained Ct.vTMD, and increased Ct.Th and total bone strength to the same extent as D-PTH

ヨナオシ ノート 2020ネンド フユ

「世直し研究会」は、2006年4月から2016年3月まで大阪大学コミュニケーションデザインセンターにおいて開催された「現場力研究会」の後継組織として2018 年4月25日に誕生し、通算で201回を数えます。月1回水曜日に大阪大学COデザインセンターで開催され、世の中の理不尽や不条理から目を逸らすことなく、「世」のあるべき姿を問いつつ、具体的な現場での課題に取り組む力を養い、「世直し」へと繋げていくことが目指されています。今回掲載したこの「世直し」ノオト（2020年度・冬）は、研究会に集う大学内外の参加者が、研究会での対話をもとに考えて綴った「ノオト（notes）」の第6弾にあたります。すなわち第26回から第31回までの研究会（2020 年8月～2021 年1月）における対話から編み出された10 編のエッセイになります。この期間に取り上げたテーマは以下の通りです。第26回（2020年8月26日） 「戦争と平和」【オンライン開催】第27回（2020年9月30日） 「世直し」うた会【オンライン開催】第28回（2020年10月28日 観劇を通して世直しを考える　～くるみざわしん作『同郷同年』～第29回（2020年11月25日） 世直し研究会メンバーの新著紹介【オンライン開催】熊野以素『“奇天烈”議会奮闘記―市民派女性市議の8 年間―』（東銀座出版社、2020年9月）北村敏泰『揺らぐいのち―生老病死の現場に寄り添う聖たち―』（晃洋書房、2020年11月）コロナ禍にあって、上記の研究会のほとんどがオンライン開催となりました。「世直し」ノオト（2020年度・夏）では「今、コロナ禍で」というテーマを取り上げましたが、本ノオトもこの状況に鑑みて、対面機会の減少が与える影響や、新たな人との接し方の可能性、今こそ求められる力ある言葉についてなど、コミュニケーションに関わる問いを投げかけたエッセイが多く見られます

ヨナオシ ノート 2021ネンド ナツ

「世直し研究会」は、2006年4月から2016年3月まで大阪大学コミュニケーションデザイン・センターにおいて開催された「現場力研究会」の後継組織として2018年4月25日に誕生し、通算で207回を数えます。月1回大阪大学COデザインセンターで開催され、世の中の理不尽や不条理から目を逸らすことなく、「世」のあるべき姿を問いつつ、具体的な現場での課題に取り組む力を養い、「世直し」へと繋げていくことが目指されています。今回掲載したこの「世直し」ノオト（2021 年度・夏）は、研究会に集う大学内外の参加者が、研究会での対話をもとに考えて綴った「ノオト（notes）」の第7 弾にあたります。すなわち第32回から第37回までの研究会（2021年2月～2021年7月）における対話から編み出された10編のエッセイになります。この期間は読書会を中心に、下記の内容を行いました。第32回（2021年2月24日）読書会［課題図書］ガブリエル・ガルシア＝マルケス著『コレラの時代の愛』（木村榮一訳, 新潮社、2006年）【オンライン開催】第33回（2021年3月24日）環境でお金を受け取る仕組み―「生態系サービスへの支払い」と関わるコスタリカの先住民居住区とその住民についての一考察―【オンライン開催】第34回（2021年4月28日）読書会［課題図書］ナディア・ムラド著『THE LAST GIRL―イスラム国に囚われ、闘いを続ける女性の物語―』（東洋館出版社、2018年）【オンライン開催】第35回（2021年5月24日）読書会［課題図書］澁谷智子著『ヤングケアラーわたしの語り：子どもや若者が経験した家族のケア・介護』（生活書院、2020年）【オンライン開催】第36回（2020年6月23日）読書会［課題図書1］中井久夫著『災害がほんとうに襲った時―阪神淡路大震災50日間の記録』（みすず書房、2011年）［課題図書2］中井久夫著『復興の道なかばで―阪神淡路大震災一年の記録』（みすず書房、2011年）【オンライン開催】第37回（2021年7月21日）「世直し」ノオト（2021年度・夏）合評会【オンライン開催】※第1回から第31回までの研究会テーマは、Co* Design 第6号から第10号に掲載の「世直し」ノオトをご覧ください

Fate of a two-dimensional bubble(Poster session 2, New Frontiers in Colloidal Physics : A Bridge between Micro- and Macroscopic Concepts in Soft Matter)

この論文は国立情報学研究所の電子図書館事業により電子化されました。2次元液槽中の気泡が、液中を液・気界面まで上昇し、その後、破裂して消滅するに至る動力学に関する実験を行った。これに関し、気泡壁の厚みの減少法則について得られた実験結果が理論的にシンプルに説明できることを報告する

The Serine/Arginine-Rich Protein Family in Rice Plays Important Roles in Constitutive and Alternative Splicing of Pre-mRNA

Ser/Arg-rich (SR) proteins play important roles in the constitutive and alternative splicing of pre-mRNA. We isolated 20 rice (Oryza sativa) genes encoding SR proteins, of which six contain plant-specific characteristics. To determine whether SR proteins modulate splicing efficiency and alternative splicing of pre-mRNA in rice, we used transient assays in rice protoplasts by cotransformation of SR protein genes with the rice Waxy(b) (Wx(b))-β-glucuronidase fusion gene. The results showed that plant-specific RSp29 and RSZp23, an SR protein homologous to human 9G8, enhanced splicing and altered the alternative 5′ splice sites of Wx(b) intron 1. The resulting splicing pattern was unique to each SR protein; RSp29 stimulated splicing at the distal site, and RSZp23 enhanced splicing at the proximal site. Results of domain-swapping experiments between plant-specific RSp29 and SCL26, which is a homolog of human SC35, showed the importance of RNA recognition motif 1 and the Arg/Ser-rich (RS) domain for the enhancement of splicing efficiencies. Overexpression of plant-specific RSZ36 and SRp33b, a homolog of human ASF/SF2, in transgenic rice changed the alternative splicing patterns of their own pre-mRNAs and those of other SR proteins. These results show that SR proteins play important roles in constitutive and alternative splicing of rice pre-mRNA