Coronary Vasospasm After 5-Fluorouracil Therapy: Case Report

Miyokard disfonksiyonu, perikardit, aritmiler ve akut koroner sendromlar 5-Florourasil (5-FU) tedavisinin yan etkileri olarak bildirilmiştir. 43 yaşında erkek hasta 1 saat önce başlayan göğüs ağrısı nedeniyle hastaneye başvurdu. Hastanın kardiyak öyküsü veya herhangi bir kardiyak risk faktörü yoktu. Hasta kolon karsinom tanısıyla 1 gün önce onkoloji bölümünde 5-FU tedavi almış. Anteriyor ve inferiyor derivasyonlarda ST segment yükselmesi mevcuttu. Hasta akut koroner sendrom kabul edilerek medikal tedavi başlandı ve daha sonra acil koroner anjiografi planlandı. Koroner anjiografi normaldi. İntravenöz nitrat tedavi altındayken hastanın göğüs ağrısı geçti ve EKG’deki ST yüksekliği geriledi. Kardiyak enzimler normal sınırlardaydı. Ekokardiyografide segment hareket bozukluğu yoktu. Hasta 5-FU e bağlı vazospastik angina kabul edildi ve ertesi gün taburcu edildi. Sonuç olarak 5-FU tedavi sonrası akut koroner sendrom gelişebilir. Özellikle kardiyak öyküsü olmayan hastalarda, sıklıkla vazospasmla ilişkilidir ve vazodilatör tedaviye iyi cevap vermektedir.Myocardial dysfunction, pericarditis, arrhythmias and acute coronary syndromes (ACS) are reported as advers effect of 5-Fluorouracil (5-FU). A 43 year-old man admitted to hospital with a chest pain one hour. He had no history of cardiac disease, and also had no any cardiovasculer risk factors. The patient had history of colon carcinoma. One day ago, 5-FU was given as chemotherapy regimen at oncology department. There was ST segment elevation on anterior and inferior derivations. He was initially managed as an acute coronary syndrome and emergency coronary angiography was then performed and it was normal. While introvenous nitroglycerin, the chest pain disappeared and ECG elevation regressed. Cardiac markers were within the normal ranges. There was no any wall motion abnormality on echocardiography. He was accepted vasospastic angina according to 5-FU and discharged after one day. Consequently, after 5-FU therapy, acute coronary syndrome may become. Frequently, it is associated with vasospasm especially patients with no cardiac history, and it response to vasodilator therapy well

The relationship between the TSH values and the Tpeak – Tend interval duration in hypothyroid patients receiving Levothyroxine treatment

Introduction. Changes in thyroid hormone level can affect the cardiovascular system. The aim of this study was to show how the Tpeak -Tend (Tpe) interval, which is a new marker of ventricular arrythmia, is affected in patients who have become euthyroid following Levothyroxine treatment for hypothyroidism, as this has not been examined previously in literature

Characteristics of poisoning cases in Adiyaman city

Objective: Aim of this study was to retrospectively evaluate poisoning cases in an intensive care unit (ICU) in order to determine the profile of poisoning cases, update epidemiological data in Adiyaman, and contribute to data about poisoning in our country. Methods: Between 01-01-2012 and 31-12-2013 174 patients (116 males, 58 females) with a mean age of 23.7 years were treated. Demographic characteristics, reasons and ways of poisoning, types of toxic substances, length of their ICU stay and prognosis were evaluated. Results: 2733 patients admitted to the intensive care unit were 174 poisoning cases. Poisoning ways were suicide by drug overdose (n=162, 93.1%), and accidental poisoning (n=12,6.9%).119 patients (66.5%) had single drug intake, thirty-three patients (18.4%) with multiple drug intake, and 16 (8.9%) were poisoned by organic phosphates. The most common drug used for suicide was antidepressants (n=87.5%). 32 patients (18.4%) took analgesics and anti-inflammatory drugs. A total of 152 patients taking the drug, 22 patients were poisoned by other means. The median length of patient stay was 2 days (range 1-20 days). Ninety-nine patients (56.9%) recovered and were discharged.72 patients (41.4%) were admitted to inpatient after intensive care unit. Patients were followed up by asking poisoning suicidal psychiatric consultation.1 patient was followed up for 20 days in intensive care due to alcohol poisoning but was died.2 patients (1.1%) were referred to a center forward. Conclusion: Majority of the patients were females, who took drugs with suicidal intention. Frequent use of antidepressants, which are not subject to control by authorities, to commit suicide was remarkable

Coronary Vasospasm After 5-Fluorouracil Therapy: Case Report

Myocardial dysfunction, pericarditis, arrhythmias and acute coronary syndromes (ACS) are reported as advers effect of 5-Fluorouracil (5-FU). A 43 year-old man admitted to hospital with a chest pain one hour. He had no history of cardiac disease, and also had no any cardiovasculer risk factors. The patient had history of colon carcinoma. One day ago, 5-FU was given as chemotherapy regimen at oncology department. There was ST segment elevation on anterior and inferior derivations. He was initially managed as an acute coronary syndrome and emergency coronary angiography was then performed and it was normal. While introvenous nitroglycerin, the chest pain disappeared and ECG elevation regressed. Cardiac markers were within the normal ranges. There was no any wall motion abnormality on echocardiography. He was accepted vasospastic angina according to 5-FU and discharged after one day. Consequently, after 5-FU therapy, acute coronary syndrome may become. Frequently, it is associated with vasospasm especially patients with no cardiac history, and it response to vasodilator therapy well