124 research outputs found
Validation of endogenous reference genes in rat cerebral cortex for RT-qPCR analyses in developmental toxicity studies
Adverse Outcome Pathway External Review Report AOP 54: Inhibition of Na+/I- symporter (NIS) decreases TH synthesis leading to learning and memory deficits in children
Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides
Abstract Pesticide exposure during fetal life can lead to low birth weight and is commonly observed in reproductive toxicology studies. Associations have also been found in low birth weight babies born from pesticide-exposed gardeners. Since low birth weight is also linked to metabolic disorders, it can be speculated that early life exposure to pesticides could increase the risk of becoming obese or developing diabetes later in life. We have analyzed potential long-term effects of gestational and lactational exposure to a low dose mixture of six pesticides that individually can cause low birth weight: Cyromazine, MCPB, Pirimicarb, Quinoclamine, Thiram, and Ziram. Exposed male offspring, who were smaller than controls, displayed some degree of catch-up growth. Insulin and glucagon regulation was not significantly affected, and analyses of liver and pancreas did not reveal obvious histopathological effects. Efforts towards identifying potential biomarkers of metabolic disease-risk did not result in any strong candidates, albeit leptin levels were altered in exposed animals. In fat tissues, the key genes Lep, Nmb and Nmbr were altered in high dosed offspring, and were differentially expressed between sexes. Our results suggest that early-life exposure to pesticides may contribute to the development of metabolic disorders later in life
Adverse Outcome Pathway External Review Report AOP 42: Inhibition of thyroperoxidase and subsequent Adverse Neurodevelopmental Outcomes in Mammals
Severe Hypothyroxinemia, But No Behavioural or Auditory Effects in Rats, After Developmental Exposure to a Brominated Flame Retardant
- …