Sör William’ın muaşakası

Alexandre Dumas'nın Hanımlara Mahsus Gazete'de yayımlanan Sör William’ın Muaşakası adlı romanının ilk ve son tefrikalar

Исследование процесса каталитической депарафинизации дизельных топлив

Объект исследования – процесс каталитической депарафинизации дизельных топлив. Цель работы заключается в повышении эффективности работы установки каталитической гидродепарафинизации дизельного топлива путем подбора оптимальных технологических режимов с применением метода математического моделирования. В процессе исследования была создана модель реактора депарафинизации с использованием системы HYSYS, проведена оценка влияния технологических параметров на процесс каталитической депарафинизации. Подобраны оптимальные температуры процесса депарафинизации для производства дизельного топлива зимнего и арктического в зависимости от состава сырья.The object of research is the process of catalytic dewaxing of diesel fuels. The purpose of the work is to increase the efficiency of the catalytic hydrodewaxing of diesel fuel by selecting the optimal technological regimes using the mathematical modeling method. During the research, a model of a dewaxing reactor was developed using the HYSYS system, an assessment of the effect of process parameters on the catalytic dewaxing process was carried out. Optimum temperatures of the process of dewaxing for the production of winter and Arctic diesel oil, depending on the composition of the raw materials, were selected

Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II study

BACKGROUND: The aim of the study was to determine the maximal tolerated dose (MTD) of gemcitabine every two weeks concurrent to radiotherapy, administered during an aggressive program of sequential and simultaneous radiochemotherapy for locally advanced, unresectable non-small cell lung cancer (NSCLC) and to evaluate the efficacy of this regime in a phase II study. METHODS: 33 patients with histologically confirmed NSCLC were enrolled in a combined radiochemotherapy protocol. 29 patients were assessable for evaluation of toxicity and tumor response. Treatment included two cycles of induction chemotherapy with gemcitabine (1200 mg/m(2)) and vinorelbine (30 mg/m(2)) at day 1, 8 and 22, 29 followed by concurrent radiotherapy (2.0 Gy/d; total dose 66.0 Gy) and chemotherapy with gemcitabine every two weeks at day 43, 57 and 71. Radiotherapy planning included [(18)F] fluorodeoxyglucose positron emission tomography (FDG PET) based target volume definition. 10 patients were included in the phase I study with an initial gemcitabine dose of 300 mg/m(2). The dose of gemcitabine was increased in steps of 100 mg/m(2 )until the MTD was realized. RESULTS: MTD was defined for the patient group receiving gemcitabine 500 mg/m(2 )due to grade 2 (next to grade 3) esophagitis in all patients resulting in a mean body weight loss of 5 kg (SD = 1.4 kg), representing 8% of the initial weight. These patients showed persisting dysphagia 3 to 4 weeks after completing radiotherapy. In accordance with expected complications as esophagitis, dysphagia and odynophagia, we defined the MTD at this dose level, although no dose limiting toxicity (DLT) grade 3 was reached. In the phase I/II median follow-up was 15.7 months (4.1 to 42.6 months). The overall response rate after completion of therapy was 64%. The median overall survival was 19.9 (95% CI: [10.1; 29.7]) months for all eligible patients. The median disease-free survival for all patients was 8.7 (95% CI: [2.7; 14.6]) months. CONCLUSION: After induction chemotherapy, the maximum tolerated dose and frequency of gemcitabine was defined at 500 mg/m(2 )every two weeks in three cycles during a maximum of 7 weeks of thoracic radiotherapy for the phase II study. This regimen represents an effective and tolerable therapy in the treatment of NSCLC

Автоматизированная система управления бизнес-процессами на базе малого предприятия

Проектирование системы автоматизированного управления бизнес-процессами на базе малого предприятия по производству пластика для 3D-печати. Объектом исследования является бизнес-процессы, протекающие на предприятии по производству пластика для 3D-печати Целью работы является разработка системы управления бизнес-процессами.Designing an automated business process management system based on a small plastic manufacturing enterprise for 3D printin