Assessment of critical success factors transformation in ERP projects

The high value of ERP projects for business, as well as the high risks associated with these projects implementation, requires studying the success drivers of ERP projects and developing a methodology to assess potential transformation of success factors into risk factors in a phased project diagnosis on different life cycle stages. The paper defines and systematizes the key factors, which influence the results of ERP system implementation. The main approaches used are as follows: logical modeling, statistical techniques, heuristic techniques, such as questionnaires, interviews of representative groups of IT project managers, human resource managers, heads of technical and business units, that allowed to authors prove the most important critical success factors relating to human resources management. Research of the 22 autonomous critical factors grouped by key players and activities; the authors defined two independent criteria that determine the nature of critical factors effects on project results and present a methodology to assess the potential human-related (“soft”) critical success factors of ERP projects and their transformation into factors of risk. The results could be of use to business executives, business consultants, managers and professionals, providing them with an effective tool to identify and eliminate causes that threaten the project success. © 2016 Pecherskaya et al

Theoretical and methodological approaches to the study of interregional interactions in ensuring economic security

The adoption of strategies for the spatial development of the Russian Federation, national and economic security has brought the study of inter-regional interactions up to date. In this regard, the authors have reviewed the theoretical and methodological approaches of domestic and foreign scientists to the issues of interregional cooperation in various branches of science and production. Interpretations of the concepts “inter-regional interaction”, “economic security” and “economic security of the region” are analysed. The role of inter-regional cooperation, especially inter-regional investment projects, as critical factors in ensuring regional economic security is emphasised. Groups of potential risks and risk-forming factors for joint inter-regional infrastructure projects are identified. Interregional projects are classified according to their scope and purpose: 1) in the production sphere; 2) projects promoting innovation; 3) projects aiming at infrastructure development. Examples of existing interregional projects in the Ural Federal District are presented. The study uses general scientific methods, in particular, analysis and synthesis. The results of the study can serve as a basis for the further development of new theoretical and methodological approaches to solving the problems of inter-regional cooperation

The local repolarization heterogeneity in the murine pulmonary veins myocardium contributes to the spatial distribution of the adrenergically induced ectopic foci

An atrial tachyarrhythmias is predominantly triggered by a proarrhythmic activity originate from the pulmonary veins (PV) myocardial sleeves; sympathetic or adrenergic stimulation facilitates PV proarrhythmia. In the present study the electrophysiological inhomogeneity, spatiotemporal characteristics of the adrenergically induced ectopic firing and sympathetic nerves distribution have been investigated in a murine PV myocardium to clarify mechanisms of adrenergic PV ectopy. Electrically paced murine PV demonstrate atrial-like pattern of conduction and atrial-like action potentials (AP) with longest duration in the mouth of PV. The application of norepinephrine (NE), agonists of α- and β-adrenergic receptors (ARs) or intracardiac nerves stimulation induced spontaneous AP in a form of periodical bursts or continuous firing. NE- or ARs agonists-induced SAP originated from unifocal ectopic foci with predominant localization in the region surrounding PV mouth, but not in the distal portions of a murine PV myocardium. A higher level of catecholamine content and catecholamine fiber network density was revealed in the PV myocardial sleeves relative to LA appendage. However, no significant local variation of catecholamine content and fiber density was observed in the murine PV. In conclusion, PV mouth region appear to be a most susceptible to adrenergic proarrhythmia in mice. Intrinsic spatial heterogeneity of AP duration can be considered as a factor influencing localization of the ectopic foci in PV. © 2019, The Physiological Society of Japan and Springer Japan KK, part of Springer Nature.18-34-00931The study is supported by RFBR 18-34-00931 grant. AP Action potentials AR Adrenergic receptors EAD Early afterdepolarization DAD Delayed afterdepolarization DD Diastolic depolarization SAP Spontaneous action potentials RMP Resting membrane potentials LA Left atria LAA Left atria appendage PKA Proteinkinase A PV Pulmonary veins PNS Postganglionic nerves stimulation NCX Natrium-sodium exchanger NE Norepinephrine PHE Phenylephrine ISO Isoproterenol

Methodology of contract managers’ project competency formation in CPE

The paper defines and systematizes the key methods, which influence the results of continuing professional education (further referred to as “CPE”) implementation and quality control of CPE process. All this will allow providing coaches, tutors, business consultants, contract managers and professionals with an effective tool to identify and improve project competency of contract managers (contract officers, specialists in procurement further referred to as “contract managers”). The key methodused is a logicalmodeling, which allows to examine the problem of project competency formation as a purposeful and conscious process of forming professional skills of contract managers. The following approaches were also used: statistical and heuristic techniques, such as questionnaires, interviews of representative groups of contract managers. The authors introduce a study on key points in formation of project competency of contract managers at different levels: as a specialist in procurement and expert in procurement, according to professional standards, adopted by the Ministry of Labour of the Russian Federation № 625n and № 626n of 10.09.2015. The authors give some recommendations on project competency formation of contract managers, taking into consideration competency-based and business oriented training. The mentioned above approach in CPE, in authors’s opinion, contributes to the efficient development of competencies (competency clusters) of contract managers according to the expectations and interests of employers on the labour market. Aspects of project competency and stages of formation of such competency are considered from several perspectives. In order to cover above-mentioned issues the specially developed questionnaire was suggested by authors. The authors used a systematic literature review approach, starts with literature review, problems identification, selection process, assess, synthesize and write down the ideas proposed, and then make conclusions. © 2016 Pecherskaya et al

The algorithm for applying the rating system of evaluation as an effective method of influencing the activation of cognitive activity of students

The algorithm for applying the rating system of evaluation as an effective method of influencing the activation of cognitive activity of students / Olena Fedorenko, Lidia Pletenytska, Kateryna Averina and oth. // Journal of Critical Reviews. – 2020. – Vol. 7, Issue 13. – P. 106-108. – DOI: http://dx.doi.org/10.31838/jcr.07.13.17.Fedorenko, O., Pletenytska, L., Averina, K., Honcharuk, V., Danilevich, L. The algorithm for applying the rating system of evaluation as an effective method of influencing the activation of cognitive activity of students (2020) Journal of Critical Reviews, 7(13), pp. 106-108. DOI: 10.31838/jcr.07.13.17.У статті представлений алгоритм застосування рейтингової системи оцінювання для ефективного впливу на активізацію пізнавальної діяльності студентів. Пропонується 100-бальний рейтинг оцінювання студентів, який враховує основні критерії, такі як творче мислення, індивідуальність, самостійна робота, оригінальність індивідуальних завдань, навчальна пунктуальність, регулярне відвідування занять.The article presents an algorithm for applying the rating system of assessment to effectively influence the activation of cognitive activity of students. A 100-point student assessment rating is proposed, which takes into account the main criteria, such as creative thinking, individuality, independent work, originality of individual tasks, educational punctuality, regular attendance of classes.В статье представлен алгоритм применения рейтинговой системы оценивания для эффективного влияния на активизацию познавательной деятельности студентов. Предлагается 100-бальный рейтинг оценивания студентов, учитывающий основные критерии, такие как творческое мышление, индивидуальность, самостоятельная работа, оригинальность индивидуальных задач, учебная пунктуальность, регулярное посещение занятий

Import Replacement for Arctic Projects Implementation

The article is aimed at examining one of the most important social and economic task – the systemic development of the Arctic zone as regards solving the problem of dependence of the Russian oil and gas industry on foreign technologies and equipment. As the main approach, we propose anticipatory import substitution, which presupposes the orientation of importsubstituting products not only to domestic but also to external markets. The author’s approach to import substitution implies the creation of effective mechanisms for the development of interregional cooperation through oil and gas companies - local suppliers of products and services. As an object of study we selected industrial enterprises of the Sverdlovsk region and economic entities of natural monopolies located in the territory of the northern part of Tyumen region. Their interaction is estimated by еру authors from the position of regional marketing by highlighting the marketing outlines of this interaction. As a result of the research, the Russian market of equipment and technologies for the oil and gas sector was characterized, with its features and the latest changes in the conditions of the economic sanctions revealed. We formulate the problems, opportunities and directions of import substitution of products used by oil and gas producing enterprises in the development of the Russian Arctic using the scientific and production potential of the Sverdlovsk region enterprises. The results can be used for the development of strategic and program documents at a federal and regional level aimed at addressing the problems of Arctic development. The study showed that the policy of import substitution of industrial production for the North and the Arctic should be based on the principles of innovative growth and focus on the subsequent export orientation of products. The emphasis was on the search for new opportunities for the growth of Ural exports through the formation of new technological markets based on the introduction of new technologies.Статья направлена исследование важнейшей социально-экономической задачи – системного освоения Арктической зоны в части решения проблемы зависимости российской нефтегазовой отрасли от иностранных технологий и оборудования. В качестве основного подхода предлагается опережающее импортозамещение, предполагающего ориентацию замещающей импорт продукции не только на внутренний, но и на внешний рынки. Авторский подход по импортозамещению подразумевает создание действенных механизмов развития межрегионального сотрудничества по линии «нефтегазовые компании – локальные поставщики продукции и услуг». В качестве объекта исследования выбраны промышленные предприятия Свердловской области и хозяйствующие субъекты естественных монополий, дислоцированных на территории Тюменского Севера. Их взаимодействие авторами оценивается с позиции регионального маркетинга путем выделения маркетинговых контуров данного взаимодействия. В результате исследования охарактеризован рынок оборудования и технологий для нефтегазового комплекса Российской Федерации, выявлены его особенности и последние изменения в условиях действия экономических санкций. Сформулированы проблемы, возможности и направления импортозамещения продукции, используемой нефтегазодобывающими предприятиями при освоении и развитии российской Арктики с использованием научного и производственного потенциала предприятий Свердловской области. Результаты могут быть использованы при формировании стратегических и программных документов федерального и регионального уровня направленных на решение проблем освоения Арктики. Исследование показало, что политика импортозамещения промышленного производства для Севера и Арктики должна формироваться на принципах инновационного роста и развития последующей экспортной ориентации продукции. Сделан акцент на поиске новых возможностей роста уральского экспорта за счет формирования новых технологических рынков на основе внедрения новых технологий.Публикация подготовлена в соответствии с государственным заданием ФАНО России для ФГБУН Института экономики УрО РАН на 2018 г., в рамках проекта №18-6-7-42 «Социально-экономическое развитие Арктической зоны Урала: потенциальные возможности, приоритеты и перспективы пространственного освоения

Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18

Russia has one of the highest rates of cardiovascular disease in the world. The International Project on Cardiovascular Disease in Russia (IPCDR) was set up to understand the reasons for this. A substantial component of this study was the Know Your Heart Study devoted to characterising the nature and causes of cardiovascular disease in Russia by conducting large cross-sectional surveys in two Russian cities Novosibirsk and Arkhangelsk. The study population was 4542 men and women aged 35-69 years recruited from the general population. Fieldwork took place between 2015-18. There were two study components: 1) a baseline interview to collect information on socio-demographic characteristics and cardiovascular risk factors, usually conducted at home, and 2) a comprehensive health check at a primary care clinic which included detailed examination of the cardiovascular system. In this paper we describe in detail the rationale for, design and conduct of these studies.The International Project on Cardiovascular Disease in Russia (IPCDR) project was supported in part by a Wellcome Trust Strategic Award [100217]. The project was also funded by the Arctic University of Norway, UiT in Tromsø; Norwegian Institute of Public Health; the Norwegian Ministry of Health and Social Affairs

ДЕЙСТВИЕ АНТИОКСИДАНТА SKQ1 НА СТРУКТУРНОФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ МОЗГА В ПОСТРЕАНИМАЦИОННОМ ПЕРИОДЕ

The aim was to assess the efficacy of mitochondriatargeted antioxidant SkQ1 in prevention of structural and functional abnormalities of brain postresuscitation after cardiac arrest.Materials and methods. Adult male Wistar rats (n=19) underwent cardiac arrest for 7 minutes followed by resuscitation. Nine rats were administered with 500 nmol/kg SkQ1 per os with water for 2 weeks (1 week before and 1 week after resuscitation). A control group consisted of shamoperated animals (n=10). At days 4—6 post operation locomotor activity and anxiety («elevated plus maze» test) and sensorimotor function of limbs («beam walking» test) were examined. Total numbers of neurons per 1 mm of their layer length in vulnerable neuronal populations (cerebellar Purkinje cells and piramidal neurons of hippocampus fields CA1 and CA4) were estimated by histological analysis of the specimens stained with cresyl violet on day 7 postresuscitation. To identify possible mechanisms of SkQ1 action, the immunohistochemical study of a glialderived neurotrophic factor (GDNF) expression in piramidal neurons of hippocampus was performed by indirect peroxidaseantiperoxidase method and antiGDNF primary polyclonal antibodies.Results. Ischemiareperfusion resulted in neuronal loss in all studied brain areas followed by reduction in locomotor activity and development of sensorimotor deficit. SkQ1 prevented development of postresuscitative locomotor and sensorimotor irregularities, significantly reduced Purkinje cells loss, prevented death of piramidal neurons in hippocampal field CA4, but not in CA1. Data demonstrated, that iIn Purkinje cells from resuscitated rats treated with SkQ1 there was a significant increase in number of GDNFpositive neurons, which were more resistant to ischemia (transition of GDNFnegative cells toward the category of cells actively expressing this factor) that promoted their survival postresuscitation.Conclusion. Data confirm the positive effects of SkQ1 on structural and functional status of the brain postre suscitation and suggest possible use of SkQ1 for the prevention or correction of posthypoxic encephalopathies.Цель работы — оценка эффективности митохондриальнонаправленного антиоксиданта SkQ1 для предупреждения постреанимационных нарушений структурнофункционального состояния мозга.Материалы и методы. У 19 половозрелых самцов крыс Вистар вызывали остановку сердца на 7 минут с последующей реанимацией. Часть животных (n=9) получала SkQ1 перорально в дозе 500 нмоль/кг с водой в течение 2х недель (1 неделю до и 1 неделю после реанимации). Контролем служили ложнооперированные животные (n=10). На 4—6е сутки после реанимации у крыс оценивали двигательную активность и тревожность (тест «приподнятый крестообразный лабиринт»), а также сенсомоторную функцию конечностей (тест «сужающаяся дорожка»). Через 7 суток после реанимации на препаратах, окрашенных по Нисслю, определяли плотность нейронов на 1 мм длины их слоя в высокочувствительных к гипоксии нейрональных популяциях (пирамидные нейроны полей СА1 и СА4 гиппокампа, клетки Пуркинье мозжечка). Для выявления возможных механизмов действия SkQ1 проводили иммуногистохимическое исследование экспрессии глиального нейротрофического фактора (GDNF) непрямым пероксидазноантипероксидазным методом с использованием первичных поликлональных антител против GDNF.Результаты. Обнаружено, что ишемияреперфузия приводит к гибели нейронов во всех исследованных отделах мозга, что сопровождается снижением двигательной активности и развитием сенсомоторного дефицита. Применение SkQ1 предупреждает развитие постреанимационных двигательных и сенсомоторных нарушений, существенно уменьшает гибель клеток Пуркинье мозжечка, предотвращает гибель пирамидных нейронов в поле СА4 гиппокампа, но не в поле СА1. Показано, что в популяции клеток Пуркинье мозжечка применение SkQ1 сопровождается увеличением числа GDNFположительных нейронов, более устойчивых к ишемии (переход части GDNFотрицательных клеток в категорию активно экспрессирующих этот фактор нейронов), что способствует их выживанию в постреанимационном периоде.Заключение. Полученные в работе данные свидетельствуют о положительном воздействии SkQ1 на структурнофункциональное состояние мозга в постреанимационном периоде, что обуславливает перспективность применения этого препарата для предотвращения и коррекции постгипоксических энцефалопатий