Experimental Regeneration of The Periodontium

The biologic possibility of regenerating periodontal tissues,especially bone, lost due to chronic inflammatory periodontal disease has fascinated researchers for over 100 years. During the past 15 years, an explosion of new knowledge in the area of periodontal physiology coupled with the application of novel techniques in cellular and molecular biology has shed new light on the biologic possibilities of regenerating periodontal tissues. Along with the breakthroughs, we have generated more challenging questions and controversies. Wound healing in general has been described in the biomedical literature using a timescale compartmentalization (for review, see Clark1). Wound healing in the periodontium may best be considered as unusual combinations of biologic phenomena, typically inconsistent and incompletely understood. This article reviews the current knowledge in the area of wound repair and regeneration of periodontal tissues that have been lost due to chronic inflammatory disease