5 research outputs found
RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis
The intracellular levels and activity of RhoA and RhoC, two closely related homologues of the RhoGTPase family, are interdependent, and their cross-talk requires RhoGDIά. This dynamic balance regulates the activation of the ROCK downstream effector and the expression of several genes, including NAG-1, that alter tumorigenesis in vitro and in vivo