Decompressive cervical laminectomy and lateral mass screw-rod arthrodesis. Surgical analysis and outcome

<p>Abstract</p> <p>Background</p> <p>This study evaluates the outcome and complications of decompressive cervical Laminectomy and lateral mass screw fixation in 110 cases treated for variable cervical spine pathologies that included; degenerative disease, trauma, neoplasms, metabolic-inflammatory disorders and congenital anomalies.</p> <p>Methods</p> <p>A retrospective review of total 785 lateral mass screws were placed in patients ages 16-68 years (40 females and 70 males). All cases were performed with a polyaxial screw-rod construct and screws were placed by using Anderson-Sekhon trajectory. Most patients had 12-14-mm length and 3.5 mm diameter screws placed for subaxial and 28-30 for C1 lateral mass. Screw location was assessed by post operative plain x-ray and computed tomography can (CT), besides that; the facet joint, nerve root foramen and foramen transversarium violation were also appraised.</p> <p>Results</p> <p>No patients experienced neural or vascular injury as a result of screw position. Only one patient needed screw repositioning. Six patients experienced superficial wound infection. Fifteen patients had pain around the shoulder of C5 distribution that subsided over the time. No patients developed screw pullouts or symptomatic adjacent segment disease within the period of follow up.</p> <p>Conclusion</p> <p>decompressive cervical spine laminectomy and Lateral mass screw stabilization is a technique that can be used for a variety of cervical spine pathologies with safety and efficiency.</p

Les marqueurs érythrocytaires d'une population Khmer de donneurs de sang

ERYTHROCYTE MARKERS IN CAMBODIAN BLOOD DONORS Summary. — Gene frequencies of seven polymorphism systems : ABO, Rhesus, MNSs, Duffy, Kell, Lutheran and P, have been investigated in 110 unselected Cambodian of Khmer origin blood donors from the Economy and Trade Hospital in Phnom-Penh (Kampuchia). Gene couting was done in virtually all the systems and Hardy-Weinberg's equilibrium was performed. A detailed comparison of gene and haplotype frequencies with those of the other asian populations was done.Résumé. — Les fréquences géniques de sept systèmes de polymorphisme : ABO, Rhésus, MNSs, Duffy, Kell, Lutheran et P, ont été étudiées chez 110 donneurs de sang non apparentés cambodgiens d'orgine Khmer, provenant de l'hôpital de l'Economie et du Commerce de Phnom-Penh (Kampuchia). Le bon ajustement des résultats a été vérifié et l'équilibre Hardy-Weinberg recherché. Une comparaison détaillée des fréquences des différents gènes et haplotypes avec celles des populations de l'Asie a été faite.Hoang B., Le Xuang P., Audat F., Jaulmes B. Les marqueurs érythrocytaires d'une population Khmer de donneurs de sang . In: Bulletins et Mémoires de la Société d'anthropologie de Paris, XIV° Série. Tome 4 fascicule 3, 1987. pp. 181-190

Bull Cancer

L’évolution des techniques de greffe et de typage HLA rend plus facile l’identification d’un donneur en vue d’une allogreffe de cellules souches hématopoïétiques (CSH). Cette activité, fortement encadrée par des textes réglementaires ou normatifs, implique de plus une évaluation biologique, médicale, paramédicale et parfois psychologique. La discussion bénéfice/risque est compliquée car elle doit tenir compte du rapport bénéfice/risque pour le receveur, et du risque donneur. Aucune donnée d’ Evidence-Based Medecine n’est disponible et les événements graves, très rares, relèvent de situations casuistiques. Les déclarations de biovigilance et leur analyse ont une importance fondamentale. Certaines contre-indications évidentes et définitives pourraient être dépistées très en amont de la démarche. Il est important d’évaluer si un facteur de risque ou une pathologie contribue à augmenter le risque associé au prélèvement. En cas de risque receveur, la situation doit être discutée avec l’équipe prenant en charge le patient. Ces recommandations sont centrées sur les donneurs adultes de CSH du sang périphérique. Elles concernent l’information du donneur, la confidentialité des échanges, l’impact de pressions morales ou matérielles, les déclarations de biovigilance, la collégialité et la traçabilité des décisions difficiles, l’expérience et la formation souhaitables pour les médecins en charge, le recours aux avis spécialisés éclairés par un échange explicite sur les risques redoutés, la parcimonie des interventions thérapeutiques et la minimisation du risque pour le donneur. Nous recommandons aussi la création, mise à disposition et utilisation par la communauté d’outils et documents (registres, questionnaires, recommandations synthétiques, retours d’expériences, réunions collégiales de qualification) utiles à la pratique.The evolution of HLA typing and transplantation techniques makes it easier to identify a donor for hematopoietic stem cell (HSC) transplantation. This activity, strongly regulated by regulatory or normative texts, implies in addition biological, medical, para-medical and sometimes psychological evaluations. The benefit/risk discussion is complicated because it must take into account the benefit/risk ratio for the recipient, and the donor risk. No Evidence-Based Medicine data is available and serious events are very rare situations. Biovigilance declarations and their analysis are of fundamental importance. Certain obvious and definite contraindications could be detected very early in the process. It is important to assess whether a risk factor or pathology contributes to increasing the risk associated with collection. In case of recipient risk, the situation should be discussed with the patient team. These recommendations focus on adult peripheral blood HSC donors. They refer to donor information, confidentiality of exchanges, the impact of moral or material pressures, declarations of biovigilance, collegiality and traceability of difficult decisions, desirable experience and training for doctors in charge, use of expert advice informed by an explicit exchange on the possible risks, parsimony of therapeutic interventions and minimization of risks for the donor. We also recommend creation, availability and use by the community of tools and documents (registries, questionnaires, synthetic recommendations, feedback, and collegial qualification meetings) useful for practice

Management of psychiatric complications in unrelated donor before unrelated peripheral hematopoietic stem cell collections

Olivier Hequet,1,2 Valerie Mialou,2 Francoise Audat,3 Eric Wattel,4 Valerie Chapel,4 Damiela Revesz,1 Jean-Piere Jouet,3 Brigitte Fisseaux,5 Mohamed Saoud,6 Mauricette Michallet4 1Apheresis Unit, 2Cell Therapy Laboratory, Etablissement Fran&ccedil;ais du Sang (EFS) Rh&ocirc;ne Alpes, Centre Hospitalier Lyon Sud, Pierre B&eacute;nite, 3Biomedicine Agency, Saint-Denis, 4Hematological Unit, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre B&eacute;nite, 5Psychiatric Unit, Hospices Civils de Lyon, Centre Hospitalier, Bourgoin Jallieu, 6Psychiatric Unit, Hospices Civils de Lyon, Centre Hospitalier P&nbsp;Wertheimer, Lyon, France Abstract: Allogeneic hematopoietic stem cell transplantation can efficiently treat patients with severe hematological diseases. A human leukocyte antigen-compatible donor is required for performing transplantation. The occurrence of unexpected acute severe diseases in a donor can compromise the feasibility of allogeneic hematopoietic stem cell transplantation. However, when a severe health problem occurs in a donor while the recipient has already received a conditioning regimen, hematologists have to find the best solutions for the recipient, while the team in charge of the donor has to find the best medical solutions for the donor. We describe here the occurrence of psychiatric acute complications in an unrelated donor while the myeloablative conditioning regimen had already been given to the recipient. We report the successive decisions that were made in an emergency based upon the expertise of physicians specialized in hematology, apheresis, cell therapy, and psychiatry to preserve the donor&rsquo;s health and recipient&rsquo;s life. Keywords: hematopoietic stem cells, mobilization, harvest, psychiatric complication, CD34+ cells, unrelated dono

Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation

New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (4a&ndash;4o), were rationally designed and synthesized. The target compounds were screened for in vitro antiproliferative efficacy in the triple-negative breast cancer (TNBC) cell line, MDA-MB-231, and normal human mammary epithelial cells (HMECs). Two compounds, 4g and 4i, had the highest efficacy and selectivity towards MDA-MB-231 cells, and thus, were further evaluated by mechanistic experiments. The results indicated that both compounds 4g and 4i induced apoptosis by (1) inducing cell cycle arrest at the G2 phase in MDA-MB-231 cells, and (2) activating the intrinsic apoptotic pathways in a concentration-dependent manner. Physicochemical characterizations of these compounds suggested that they can be further optimized as potential anticancer compounds for TNBC cells. Overall, our results suggest that 4g and 4i could be suitable leads for developing novel compounds to treat TNBC