Effectiveness and safety profile of fluticasone propionate 0.05% in paediatric dermatoses

Background: Topical corticosteroids are effective in the treatment of paediatric dermatoses. However, concerns regarding possible side effects of topical steroids have limited the use of moderate-potency corticosteroids in children. Objective of this study was to evaluate the effectiveness and safety profile of fluticasone propionate 0.05% cream in paediatric dermatoses. Methods: A total 84 children between 6 months to 12 years of age with moderate to severe  dermatoses (< or =30% body surface area) were treated with fluticasone propionate 0.05% cream  twice daily for 4 to 6 weeks. Adverse effects of topical steroids were analyzed. Results: Out of total 84 patients, 46 (54.76%) patients completely cured at 4 weeks and 23 (27.38%) patients at 6 weeks, while remaining 11 (13.10%) patients showed moderate improvement, 4 were lost for follow up after 2 weeks. Only in 2 patients we observed hypopigmentatipon of skin, otherwise in all patients no significant side effect were seen. Conclusions: Fluticasone propionate 0.05% cream appears to be quite safe for the treatment of moderate to severe dermatoses for up to 4 to 6 weeks in children less than 12 years of age

Treatment with clobetasol propionate 0.025% topical therapy in various dermatoses

Owing to their anti-inflammatory and vasoconstrictive properties. Topical corticosteroids (TCs) provide benefits in various dermatological conditions, including atopic eczema, psoriasis, chronic hand eczema, and localized vitiligo. Clobetasol propionate (CP) is the most common topical agent possessing anti-inflammatory, antimitotic, antipruritic, and immunosuppressive properties that are employed in the management of plaque psoriasis. CP 0.025% cream was approved by the United States food and drug administration for the treatment of moderate-to-severe psoriasis in adult patients. The formulation is free from known contact allergens, such as propylene glycol, short-chain alcohols, and sorbitol-based emulsifiers, and has demonstrated hypoallergenic effects. High penetration of active ingredients and a lower degree of systemic absorption make CP 0.025% an effective and safe agent. This case series discusses the clinical experience of using CP 0.025% cream in various dermatologic conditions, focusing on its efficacy and safety

KNUCKLE HYPERPIGMENTATION IS A MARKER OF VITAMIN B12 DEFICIENCY IN VEGETARIAN POPULATION

BACKGROUND B12 deficiency is common in India as is Vitamin D, folic acid, or iron deficiency. Megaloblastic Anaemia due to vitamin B12 deficiency is extremely common in the predominantly vegetarian population. The symptoms are modified also by the underlying disorder causing its deficiency. Knuckle hyperpigmentation is one of the essential features of it. In spite of being a common disorder, its recognition is delayed or missed because the manifestations are diverse in nature, and is often subclinical. Laboratory estimations of B12 levels are also not reliable. The ways of picking up those with clinical or subclinical B12 deficiency and the reasons and solutions are very much needed. Here we emphasize the clinical sign of knuckle hyper pigmentation as an important clue towards the aetiology of Megaloblastic Anaemia. The aim of the study is to know the correlation of knuckle hyper pigmentation with serum vitamin B12 deficiency in vegetarian population. MATERIALS AND METHODS 40 patients with knuckle hyperpigmentation, all were vegetarian screened for serum vitamin B12 deficiency. RESULTS Out of 40 patients, 28 females and 12 males, 32(80%) patients showed decreased levels of serum Vitamin B12. CONCLUSION Vitamin B12 deficiency is not uncommon in vegetarian population and knuckle hyperpigmentation is an early marker of this and need larger studies to know it better. Knuckle pad hyperpigmentation is much more frequent than diffuse pigmentation of the palms and/or soles in such patents. Few patients with vitamin B12 deficiencies do present with severe anaemia requiring blood transfusions and often have skin hyperpigmentation

Erythema ab igne (Unilateral) due to "Chulla"

Erythema ab igne (EAI) is characterized by localized areas of reticulated erythema and hyperpigmentation due to chronic and repeated exposure to infrared radiation. Taking a good history plays an important role in coming to the diagnosis of the disease condition; and at the same time, the particular cultural practices of a place determine its occurrence in the local masses. Herein we report the case of a young lady in her early thirties who presented to us with a dusky hyperpigmentation over her right arm and leg. Her detailed history and cutaneous examination led to the diagnosis of erythema ab igne