Is the 2018 loggerhead nest really another exceptional sea turtle nesting record following the 2012 and 2016 previous nesting cases in Malta?

We report another nesting event by a loggerhead turtle in Ġnejna (Malta), in June 2018, with an extraordinary hatching rate of 99.1%. This follows the previously reported nesting in 2012 in the same bay, and the 2016 event in a nearby beach at Golden Bay, both beaches located in the NW of Malta. Before the 2012 record, scientifically recorded turtle nesting in Malta had only been reported dating back some 100 years, although in one paper it is alleged that turtles may have been nesting in Malta up until some 50-60 years ago. Noting that loggerheads have an average remigration interval of 2 years, it is possible that the same turtle that nested in 2012 came back to Ġnejna to nest again in 2018. It is hoped that DNA analysis, which ideally follows at a later stage, will determine whether it was the same turtle. Campaigns are currently ongoing to solicit greater reporting of nesting. Relocation of eggs is discussed. In this paper we also describe conservation measures that were set-up in this bay and in Golden Bay, including measures during hatching. Emergency conservation orders were issued in all the three nesting events, to protect the beaches in question from any major and potentially harmful activities. The sites were also surrounded and physically protected with a 24 hour monitoring scheme being set-up with the help of volunteers from Nature Trust Malta and government officials

An evaluation of in-patient respite care at St. Vincent de Paul Residence

Aim: To identify the multi-dimensional characteristics and need for inter-disciplinary input associated with in-patient respite care. Methods: During the period January-December 2007, 91 in-patient respite users, aged ≥60 years, were assessed on admission for respite care at St. Vincent de Paule Residence. Assessment instruments used included the Barthel Index, the Mini-Mental State Examination, a Caregiver Strain Index, the Functional Oral Intake Scale and the Communicative Effectiveness Index. Findings: Of the study group (n=91), 65% of respite users were found to be suffering from moderate to severe dementia (Mini-Mental State Examination score 0-20). High dependency on the Barthel Index (0-7/20) was found in 52% of cases whilst 45% had low dependency (13-20/20). Carer strain was reported in 60% of care-givers (carers). Interdisciplinary input requirements in the group studied included nursing in 85%, dental (83%), speech language pathology (70%), physiotherapy (39%), occupational therapy (38%), medical (33%) and social worker assistance (24%). Conclusion: Elderly respite users are a mixed group with multiple and diverse needs. In their own homes, these care needs are principally met by informal helpers who are frequently under stress. The expansion of in-patient respite services will reinforce the informal community care network and will help avoid or postpone long-term institutionalisation.peer-reviewedpeer-reviewe

Addressing present challenges in the life-cycle of wetlands management to successfully integrate sustainability and good governance

The assessment of management effectiveness during the whole life-cycle process of protected areas (PAs) has become increasingly important, due to the lack of holistic background assessment work on management processes leading to a deeper knowledge of sustainable development (SD) principles. This paper aims to serve as a practical guide through a gradation model of integrated protected area management (IPAM) by carrying out an exhaustive trans-dimensional assessment of management effectiveness, identifying a critical field of activities and developing a framework mix of strategic recommendations leading to the implementation of an effective planning process. Our results could aid in the prioritisation of key decisions towards a more in-depth understanding of how to set up a balanced IPAM, as well as to enable managers and decision-makers to focus on activities that can further pre-established aims and reach the goal of five-dimensional sustainability in terms of SD and good governance

Simple physics of the partly pinned fluid systems

In this paper, we consider some aspects of the physics of the partly pinned (PP) systems obtained by freezing in place particles in equilibrium bulk fluid configurations in the normal (nonglassy) state. We first discuss the configurational overlap and the disconnected density correlation functions, both in the homogeneous and heterogeneous cases, using the tools of the theory of adsorption in disordered porous solids. The relevant Ornstein-Zernike equations are derived, and asymptotic results valid in the regime where the perturbation due to the pinning process is small are obtained. Second, we consider the homogeneous PP lattice gas as a means to make contact between pinning processes in particle and spin systems and show that it can be straightforwardly mapped onto a random field Ising model with a strongly asymmetric bimodal distribution of the field. Possible implications of these results for studies of the glass transition based on PP systems are also discussed.Comment: 13 pages, 4 figures; v2 to appear in J. Chem. Phy

Prévenir les violences sexuelles en milieu autochtone : retour sur la formation au Programme Lanterne/Awacic

Objectifs : La violence sexuelle demeure un problème sociétal touchant tous les groupes sociaux comme les enfants. En ce sens, cette étude évalue un programme de formation à la prévention de la violence sexuelle chez les tout-petits en communautés autochtones. L’étude vise à documenter les effets de la formation au Programme Lanterne|Awacic ainsi qu’à identifier les barrières et les leviers propres à ce type de formation. Méthode : Menée auprès de 42 intervenants, cette étude évaluative de nature mixte a privilégié l’utilisation de trois types de collecte de données : le questionnaire, l’entrevue et le groupe de discussion. Résultats : Des effets positifs de la formation ont été observés à très court terme (p. ex., augmentation des connaissances et des croyances). Les résultats sont plus mitigés quant à son effet sur l’utilisation des outils à moyen terme (p. ex., faible utilisation des outils). Les résultats mettent également en exergue l’importance du processus de sécurisation culturelle dans les projets menés dans les communautés autochtones, la nécessité d’impliquer la population locale dans le projet et l’appréciation des participants face à la formation au Programme Lanterne|Awacic. Implications : La formation permet d’outiller les professionnels œuvrant auprès des enfants d’âge préscolaire à intervenir en matière de prévention de la violence sexuelle. Les résultats suggèrent néanmoins qu’un rappel de la formation aurait permis de maintenir les effets à plus long terme. En somme, les résultats indiquent la pertinence de poursuivre les efforts de prévention dans les communautés autochtones

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of these cancers with those from previous studies (930 cancers in total), we found evidence for 22 previously unidentified putative driver genes harboring coding mutations, as well as evidence for NEAT1 and FOXA1 acting as drivers through noncoding mutations. Through the temporal dissection of aberrations, we identified driver mutations specifically associated with steps in the progression of prostate cancer, establishing, for example, loss of CHD1 and BRCA2 as early events in cancer development of ETS fusion-negative cancers. Computational chemogenomic (canSAR) analysis of prostate cancer mutations identified 11 targets of approved drugs, 7 targets of investigational drugs, and 62 targets of compounds that may be active and should be considered candidates for future clinical trials

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational processes at work in morphologically normal tissue were also at work in cancer. Our observations demonstrate the existence of ongoing abnormal mutational processes, consistent with field effects, underlying carcinogenesis. This mechanism gives rise to extensive branching evolution and cancer clone mixing, as exemplified by the coexistence of multiple cancer lineages harboring distinct ERG fusions within a single cancer nodule. Subsets of mutations were shared either by morphologically normal and malignant tissues or between different ERG lineages, indicating earlier or separate clonal cell expansions. Our observations inform on the origin of multifocal disease and have implications for prostate cancer therapy in individual cases

Identification of a BRCA2-Specific modifier locus at 6p24 related to breast cancer risk

Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS discovery study. Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selected and designed for inclusion on a custom Illumina array that included a total of 211,155 SNPs as part of a multi-consortial project. DNA samples from 3,881 breast cancer affected and 4,330 unaffected BRCA2 mutation carriers from 47 studies belonging to the Consortium of Investigators of Modifiers of BRCA1/2 were genotyped and available for analysis. We replicated previously reported breast cancer susceptibility alleles in these BRCA2 mutation carriers and for several regions (including FGFR2, MAP3K1, CDKN2A/B, and PTHLH) identified SNPs that have stronger evidence of association than those previously published. We also identified a novel susceptibility allele at 6p24 that was inversely associated with risk in BRCA2 mutation carriers (rs9348512; per allele HR = 0.85, 95% CI 0.80-0.90, P = 3.9×10−8). This SNP was not associated with breast cancer risk either in the general population or in BRCA1 mutation carriers. The locus lies within a region containing TFAP2A, which encodes a transcriptional activation protein that interacts with several tumor suppressor genes. This report identifies the first breast cancer risk locus specific to a BRCA2 mutation background. This comprehensive update of novel and previously reported breast cancer susceptibility loci contributes to the establishment of a panel of SNPs that modify breast cancer risk in BRCA2 mutation carriers. This panel may have clinical utility for women with BRCA2 mutations weighing options for medical prevention of breast cancer

The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR, browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters. Finally we briefly discuss on the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, and touch on communication and outreach activities, the consortium organisation, and finally on the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. (abridged).Comment: 48 pages, 29 figures, Accepted for publication in Experimental Astronomy with minor editin

The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory. Athena is a versatile observatory designed to address the Hot and Energetic Universe science theme, as selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), X-IFU aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over a hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR (i.e. in the course of its preliminary definition phase, so-called B1), browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters, such as the instrument efficiency, spectral resolution, energy scale knowledge, count rate capability, non X-ray background and target of opportunity efficiency. Finally, we briefly discuss the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, touch on communication and outreach activities, the consortium organisation and the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. The X-IFU will be provided by an international consortium led by France, The Netherlands and Italy, with ESA member state contributions from Belgium, Czech Republic, Finland, Germany, Poland, Spain, Switzerland, with additional contributions from the United States and Japan.The French contribution to X-IFU is funded by CNES, CNRS and CEA. This work has been also supported by ASI (Italian Space Agency) through the Contract 2019-27-HH.0, and by the ESA (European Space Agency) Core Technology Program (CTP) Contract No. 4000114932/15/NL/BW and the AREMBES - ESA CTP No.4000116655/16/NL/BW. This publication is part of grant RTI2018-096686-B-C21 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. This publication is part of grant RTI2018-096686-B-C21 and PID2020-115325GB-C31 funded by MCIN/AEI/10.13039/501100011033