Immune Profiling of SARS-CoV-2; What We Know and What We Don’t Know

Coronavirus disease 2019 (COVID-19), described as World War 3, is the current worldwide health challenge and nearly all countries have so far faced this disaster. There is still no cure because of the complicated pathogenesis, however, there are several studies on track investigating different aspects of the immune response to the virus. In this review, we will provide an overview of recent investigations that have analyzed immune cells in patients with COVID-19. We will then discuss the differences in immune profiles between healthy controls and various clinical presentations, including asymptomatic, mild, moderate, and severe cases

Up and Down the Black Hole Radio/X-Ray Correlation: The 2017 Mini-outbursts from Swift J1753.5-0127

The candidate black hole X-ray binary Swift J1753.5-0127 faded to quiescence in 2016 November after a prolonged outburst that was discovered in 2005. Nearly three months later, the system displayed renewed activity that lasted through 2017 July. Here, we present radio and X-ray monitoring over˜3 months of the renewed activity to study the coupling between the jet and the inner regions of the disk/jet system. Our observations cover low X-ray luminosities that have not historically been well-sampled (L X 2 ×10 33 - 10 36 erg s -1 ; 1-10 keV), including time periods when the system was both brightening and fading. At these low luminosities, Swift J1753.5 -0127 occupies a parameter space in the radio/X-ray luminosity plane that is comparable to "canonical" systems (e.g., GX 339-4), regardless of whether the system was brightening or fading, even though during its ?11 year outburst, Swift J1753.5-0127 emitted less radio emission from its jet than expected. We discuss implications for the existence of a single radio/X-ray luminosity correlation for black hole X-ray binaries at the lowest luminosities (L X 10 35 erg s -1 ), and we compare to supermassive black holes. Our campaign includes the lowest luminosity quasi-simultaneous radio/X-ray detection to date for a black hole X-ray binary during its rise out of quiescence, thanks to early notification from optical monitoring combined with fast responses from sensitive multiwavelength facilities. © 2017. The American Astronomical Society. All rights reserved