Hyperglycemic effect and hypertotoxicity studies of stem bark of Khaya senegalensis and leaf extract of Camellia sinesis

Hepatotoxic properties of the aqueous leaves of highland tea (Camellia sinesis) and aqueous stem bark extract of Khaya senegalensis were studied in rats. This was done by assaying the serum activities of aspartate aminotransferase(AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), glucose and bilirubin in rats administered with 6.5mg/Kg (group A), 4.35mg/Kg (group B) and 3.0mg/Kg (group C) of the extract for seven (7) days respectively. The serum AST, ALT, ALP, glucose, bilirubin (total) and bilirubin (direct) in the control rats (group D) were found to be 7.62 + 1.78U/L, 11.2 + 0.38U/L , 144.9 + 23.90U/L , 4.39 + 0.08mmol/l, 0.14 + 0.03mg/dl and 0.18 + 0.04mg/dl respectively. The serum AST, ALT, glucose, bilirubin (total) and bilirubin (direct) in group A rats showed significant increase (

Nutritional status in pregnant women attending Kiru General Hospital in Kano state, Nigeria

The present study determined body weight and height (Body Mass Index-BMI) was calculated according to the formula weight (kg)/height2 (m), Blood Pressure (BP), Hemoglobin (Hb), Fasting Blood Glucose (FBS) and Total Cholesterol (TC) in pregnant women (PW) in the three trimestersand in non-pregnant women (NPW). Sixty apparently healthy pregnant women and twenty non pregnant non lactating women (age range 17-34 years) participated in the study. The results showed significant difference in BMI of the pregnant women (1st, 2nd, and 3rd trimesters) and thecontrol group (p<0.05). There was an increase in BP levels in the pregnant women when compared to the non pregnant women. The results also showed that the levels of Hb decreased significantly (p<0.05) as the pregnancy progressed through the three trimesters. However the results indicated that there was a significant increase (p<0.05) in the FBS and TC levels between the non pregnant women and pregnant women through the trimesters.Keywords: Pregnant women, non pregnant women, body mass index (BMI), blood pressure,hemoglobin, serum fasting blood glucose, total cholesterol

The effect of “Gadagi” tea on liver function and serum glucose concentration in albino rats

Effect of oral administration of “Gadagi” tea on liver function and serum glucose concentration was assessed on thirty (30) healthy non – pregnant female albino rats. The animals were grouped and administered different doses (mg/kg) i.e. (low dose; 0.75mg/kg for “Sak,” 1.40mg/kg for “Sada” and 2.10mg/kg for “magani.” Standard dose; 1.50mg/kg for “Sak,” 2.80mg/kg for “Sada” and 4.20mg/kg for “magani.” High dose; 3.00mg/kg for “Sak,” 5.60mg/kg for “Sada” and 8.30mg/kg for “magani”) for a period of one week. Animals that were not administered the tea constituted the control group. At the end of one week, the animals were sacrificed and their serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin (total and direct) and glucose levels were determined. Mean serum glucose level of the control animals was significantly higher (

Level of heavy metals in soil and some vegetables irrigated with industrial waste water around Sharada Industrial Area, Kano, Nigeria

The level of some heavy metals in soil and plant samples from Sharada Industrial Area was analyzed. Plants absorb contaminants through root systems and store them in the root biomass and/or transport them to the stem and/or leaves. The waste water generated by industries was used to irrigate plants; onion (Alium cepa), lettuce (Lactuca sativa), okra (Hibiscus esculentus), Drumstick (Moringa oleifera) and carrot (Daucus carota) which are consumed locally. The level of heavy metals in these plants differs with plant species. Level of lead (Pb) ranged from 10.21±0.20-17.14±0.10μg/g in okra and onion respectively, and the level in soil was found to be 28.00±2.00μg/g. The level of heavy metal was higher in soil than in plants studied. Accumulation of heavy metals varied from plant to plant. The soil levels of copper (Cu) was found to be 9.00±2.00 μg/g with onion having the highest value (8.00±0.10 μg/g) compared to other plants. The uptake of cobalt (Co) by plants varies with plant species. Moringa oleifera had highest concentration of cobalt (14.00±8.00μg/g) and onion had the least concentration of Co (5.00±2.00μg/g). The high values of these metals might be attributed to the use of untreated effluents from industries by farmers for the irrigation of these plants. Thus, the high values of these metals in the plant samples could put the consumers of these vegetables at health risk, since the levels of these metals in plants and soil samples are all above WHO permissible limits.Keywords: Accumulation, Heavy metals, Irrigation, Industrial effluents, Vegetable

A study of the combustion chemistry of petroleum and bio-fuel oil asphaltenes

The combustion of heavy fuel oils such as Bunker C and vacuum residual oil (VRO) are widely used for industrial applications such as furnaces, power generation and for large marine engines. There is also the possible use of bio-oils derived from biomass. Combustion of these oils generates carbonaceous particulate emissions and polynuclear aromatic hydrocarbons (PAH) that are both health hazards and have an adverse effect on the climate. This paper explores the mechanism of the formation of fine particulate soot and cenospheres. The chemical structure of petroleum asphaltene have been investigated via pyrolysis techniques. The results are consistent with a structure made up of linked small aromatic and naphthenic clusters with substituent alkyl groups, some in the long chains, with the building blocks held together by bridging groups. Other functional groups also play a role. The corresponding bio-asphaltene is made up of similar aromatic and oxygenated species and behave in an analogous way

DRAFT ANIMAL POWER UTILIZATION IN TILLAGE OPERATIONS IN BORNO STATE, NIGERIA

ABSTRACT The study was conducted in some selected Local Government Areas of Borno state, Nigeria on the use of animal power in tillage operations. Ninety-one per cent of the farmers interviewed (117) owned only a single pair of draft animals, while only 9% had two pairs. All the farmers used bulls for their tillage operations and donkeys for transportation. The study showed that farmers used draft animals for only ridging, weeding and transportation. 75% of the farmers used draft animals for ridging, 20% for weeding and 5% for transportation. The area cultivated by individual farmers varied between 1.5-6 ha. The farmers complained on lack of feed at the beginning of rainy season, poor quality of implements and lack of extension services. The study suggested for the introduction of extension services and the possibility of extending the use of animal power to other farming operations in the study area

The Impact of Fuel Properties on the Composition of Soot Produced by the Combustion of Residential Solid Fuels in a Domestic Stove

Soot is formed from the incomplete combustion of biomass and conventional fossil fuels. It consists largely of a carbonaceous core termed Elemental Carbon (EC) with adsorbed volatile organic species, commonly termed Organic Carbon (OC). Estimation of the ratio of BC/OC is critical as climate models have recognised the Global Warming Potential (GWP) of BC as the second most important climate forcing agent after carbon dioxide. This paper presents values of EC, OC and EC/TC (where TC = EC + OC) for three different soot types: Firstly, soots collected on filters from the combustion of eight fossil fuel and biomass residential solid fuels (RSF), burned in a 6 kW heating stove. Secondly, chimney soot deposits taken from 'real-life' stoves installed in domestic homes; and finally wick burner soots generated from biomass model compounds; namely eugenol, furfural and anisole. Values of the EC/TC ratios for wood logs, torrefied briquettes, coal and smokeless fuel are given. These ratios are highly dependent on burning conditions; namely the flaming and smouldering phases. The results of this study suggest that EC and OC emissions from various solid fuels differ substantially in composition and relative proportion, which is useful information for climate models

Histopathological changes in female rabbits administered with aqueous extract of Calotropis procera

Calotropis procera is an evergreen perennial shrub, which is found mainly in the arid regions and produces copious latex when cut. It has been reported to possess medicinal properties but equally pose deleterious effect in animals. In a bid to exploit its pharmacological properties, it was necessary to ascertain its level of safety. A toxicological evaluation of the aqueous extract of fresh leaves of the plant was therefore conducted in the more sensitive female rabbits of the same weight range. Low levels of phytochemicals (alkaloids, saponins, tannins, cardiac glycosides and flavonoids) were found, while elemental analyses showed traces of iron, lead, sodium, and potassium in concentrations of 0.23, 0.03, 0.82 and 9.5 mg/g, respectively. Acute toxicity study was conducted with oral administration of 200, 400, 800 and 1600 mg/kg of the extract once to groups I, II, III and IV, respectively with a 24 h observation period. Clinical signs such as mouth chewing, photophobia, bradycardia, coughing, vomiting and convulsion amongst others were noticed. Four rabbits died within 24 h and LD50 was estimated (940 mg/kg). 80, 40 and 20 mg/kg of the extract were administered daily to groups I, II, and III, respectively, during sub-acute toxicity study for 14 days. Grossly, catarrhal enteritis and mesenteric congestion of the small intestines, congestion of the lungs, hepatization and paleness of the liver, congestion and pallor of the kidney cortex, and congestion of the meninges were noticed. Histopathological examination of the tissues revealed mild pulmonary oedema and peribronchial lymphocytic infiltration of the lungs, hepatization of the liver, disruption of cardiac architecture, generalised cell necrosis and erosion of the villi of the small intestine. All the rabbits that survived gained weight, which is indicative of some nutrient value in the extract. It was concluded that the extract had dose-dependent deleterious effects on the tissues as higher dose groups were more affected. Hence, it is evident that sub-chronic toxicity studies would reveal greater lesions to better ascertain extent of damage.Key words: Calotropis procera, phytochemical, histopathology, toxicity, lesions, tissues, organs

Association Between Glomerular Filtration Rate And Body Mass Index Among Orthopaedic Patients In Kano-Nigeria

Any association between body mass index and kidney disease has so far proved inconclusive. Therefore, this study is aimed to provide association between glomerular filtration rate and body mass index among orthopaedic patients. A total of sixty (60) patients irrespective of gender were recruited. Weight and height were measured prior to the sample collection. A structured questionnaire was administered to obtain the demographic data of the subjects. Blood samples were collected from each patient by venepuncture from the antecubital vein of the forearm using disposable syringes. Serum creatinine was determined by method of Rosano et al. Body Mass Index and Glomerular Filtration Rate (eGFR) were calculated using creatinine-based equation of Modification of Diet in Renal Disease. Mean BMI was found to be higher in females (25.48±5.65) than their male counterparts (21.44±4.52), while eGFR was found to be higher in males (184.14±53.23) than in females (152.06±32.71). Subjects with eGFR ≥60 were observed to be more frequent (98.30%); normal weight individuals had higher frequency (48.33%). Positive correlation exists between BMI and eGFR in males whereas negative correlation was found in females which indicates association between body mass index and kidney function is gender related

Landscape and Residential Variables Associated with Plague-Endemic Villages in the West Nile Region of Uganda

Plague, caused by the bacteria Yersinia pestis , is a severe, often fatal disease. This study focuses on the plagueendemic West Nile region of Uganda, where limited information is available regarding environmental and behavioral risk factors associated with plague infection. We conducted observational surveys of 10 randomly selected huts within historically classified case and control villages (four each) two times during the dry season of 2006 ( N = 78 case huts and N = 80 control huts), which immediately preceded a large plague outbreak. By coupling a previously published landscape-level statistical model of plague risk with this observational survey, we were able to identify potential residence-based risk factors for plague associated with huts within historic case or control villages (e.g., distance to neighboring homestead and presence of pigs near the home) and huts within areas previously predicted as elevated risk or low risk (e.g., corn and other annual crops grown near the home, water storage in the home, and processed commercial foods stored in the home). The identified variables are consistent with current ecologic theories on plague transmission dynamics. This preliminary study serves as a foundation for future case control studies in the area