Synthesis of Some Novel 11b-Substituted Pyrimido[6,1-a]-isoquinoline Derivatives

A series of novel 11b-substituted 1,6,7,11b-tetrahydropyrimido[6,1-a]- isoquinoline-2,4-diones and 4-thioxo-1,3,4,6,7,11b-hexahydropyrimido[6,1-a]isoquinolin-2- ones were synthesized, utilizing two alternative strategies for ring closure of tetrahydroisoquinoline intermediates obtained from N-phenethyl enaminone

Synthesis of Some Novel 11b-Substituted Pyrimido[6,1-a]isoquinoline Derivatives

Dr. Venkov passed away on 21.07.2003, while this project was already in progress. We would like to dedicate this paper to his memory