2 research outputs found
Evaluation of the<i> in vitro</i> activity of isavuconazole and comparator voriconazole against 2635 contemporary clinical <i>Candida </i>and <i>Aspergillus </i>isolates
Get PDFIn Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark
No full textWe report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus
