Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters

<p>Abstract</p> <p>Background</p> <p>Organophosphates are broad class of chemicals widely used as pesticides throughout the world. We performed a cross-sectional study of associations between dialkylphosphate metabolites of organophosphates and semen quality among pesticide applicators in Majes (Arequipa), Peru.</p> <p>Methods</p> <p>Thirty-one men exposed to organophosphate (OP) pesticides and 31 non-exposed were recruited (age, 20–60 years). In exposed subjects, semen and a blood sample were obtained one day after the last pesticide application. Subjects were grouped according to levels of OP metabolites in urine. Semen samples were analyzed for sperm concentration, percentage of sperm motility, percentage of normal morphology, semen leucocytes and concentrations of fructose and zinc. Exposure to OP was assessed by measuring six urinary OP metabolites (dimethyl and diethyl phosphates and thiophosphates) by gas chromatography using a single flame photometric detector.</p> <p>Results</p> <p>Diethyldithiophosphate (p = 0.04) and diethylthiophosphate (p = 0.02) better reflected occupational pesticide exposure than other OP metabolites. Semen analysis revealed a significant reduction of semen volume and an increase in semen pH in men with OP metabolites. Multiple regression analysis showed that both occupational exposure to pesticides and the time of exposure to pesticides were more closely related to alterations in semen quality parameters than the single measurement of OP metabolites in urine.</p> <p>Conclusion</p> <p>The study demonstrated that occupational exposure to OP pesticides was more closely related to alterations in semen quality than a single measurement of urine OP metabolites. Current measurement of OP metabolites in urine may not reflect the full risk.</p

Collaborative Networks for Sustainable Human Capital Management in Women’s Tourism Entrepreneurship: The role of tourism policy

Government policies to support women’s empowerment in tourism through sustainable human capital management (HCM) is an emerging research theme. Tourism policies can contribute significantly to African women’s empowerment by breaking existing stereotypical barriers that impede women’s HCM. Based on a narrative analysis of published academic and policy literature, we uncover how policy support for collaborative networks can enhance women entrepreneur’s HCM and thereby increase their resiliency and that of their tourism businesses. Collaborative networks are regional and country-specific forums, programs and/or initiatives for networking, skills development and access to resources and agency for women tourism entrepreneurs. Drawing on findings from analyzing collaborative networks involving women entrepreneurs in Ghana, Nigeria and Cameroon, the paper develops a conceptual framework that depicts four determinants of collaborative networks that influence the HCM of women entrepreneurs in tourism, namely type of network, resources, social capital dimensions and human capital management. Finally, the paper explicates how these determinants can inform national tourism policy to support women entrepreneurs