Conflictos y transformaciones sociales en Colombia: un abordaje multidisciplinario

A través de esta colección hemos puesto a disposición de la comunidad académica, nacional y regional, el conocimiento producido por nuestros profesores y estudiantes, la mayoría de ellos vinculados como investigadores a los grupos de investigación de la Facultad: el Grupo de Estudios e Investigaciones Socio jurídicas (GEIS) y PAIDEIA, espacios en los cuales se han desplegado un importante conjunto de proyectos de investigación e iniciativas académicas de diversa índole, con distintos niveles de profundidad y alcance que dan cuenta de la vitalidad y dinamismo que ha adquirido la investigación en nuestra Facultad y en la Fundación con el pasar de los años. Conflictos y transformaciones sociales en Colombia. Un abordaje multidisciplinario es un esfuerzo editorial que da cuenta de este proceso. En sus páginas el lector se encontrará, como su subtítulo lo indica, con un abordaje que más que interdisciplinario es en realidad multidisciplinario, tal y como lo es nuestra Facultad.Facultad de Ciencias Jurídicas, Sociales y Humanísticas (Pereira)Presentación - 4 ¿Racionalidad weberiana?. El proceso formativo del Estado - 8 en Colombia. Una mirada a través de la colonización en el Quindío a finales del Siglo XIX y comienzos del XX. Condiciones socio jurídicas de la población negra del Palenque - 49 de Egoyá en 1785. La agenda trans en el proceso de-constructivo de la política - 78 pública LGTBI de Bogotá (2006-2008). La reforma de la Constitución en Colombia y el juicio de - 124 sustitución de la Constitución. Reflexiones acerca de su fundamento, racionalidad y justificación

Aelurostrongylus abstrusus Infections in Domestic Cats (Felis silvestris catus) from Antioquia, Colombia

Although Aelurostrongylus abstrusus infections in domestic cats (Felis silvestris catus) have sporadically been reported in Colombia, there is still no data available on epidemiology nor on the biology of this neglected lungworm parasite. Thus, this epidemiological study aimed to evaluate the occurrence of patent A. abstrusus infections in domestic cats from the Colombian Federal State of Antioquia. In total, 473 fecal samples of indoor/outdoor domestic cats were collected and analyzed thereafter by the Baermann funnel migration technique for the presence of A. abstrusus first stage larvae 1 (L1). The occurrence of A. abstrusus was confirmed in 0.4% (2/473) of investigated cats. Due to the presence of patent A. abstrusus infections in investigated cats, it is unfailing to include this lungworm within differential diagnoses of feline pulmonary disorders. Despite the fact that the Baermann funnel technique is currently the cheapest and the gold standard diagnostic tool for feline aelurostrongylosis, this technique is still unknown by Colombian veterinary surgeons and rarely utilized in small animal veterinary clinics. The current survey intends to generate awareness on this neglected parasitosis and to be considered as a baseline study for future surveys monitoring feline aelurostrongylosis not only in domestic/stray cats but also in endemic wild felid species of Colombia

Conflictos y transformaciones sociales : un abordaje multidisciplinario

132 páginas : gráficos ; 27 cm.Reposa en manos del lector una obra de contenido sociojurídico que intenta debatir en diversos escenarios algunos problemas relevantes que han contribuido históricamente a la metamorfosis del Estado colombiano desde sus orígenes hasta la actualida

A multimodal view at cancerous liver tissue by chemical bioimaging and image segmentation strategies

Six complementary biomedical imaging modalities are combined providing substantial correlation capabilities between optical, elemental and molecular tissue characteristics. Diseased rat liver tissue with hepatocellular carcinoma (HCC) was investigated, as liver cancer is a leading cause of tumor-related mortality. Bright field microscopy, autofluorescence microscopy and histological examination of hematoxylin-eosin-stained tissue displayed comprehensive optical tissue characteristics. Elemental imaging by non-destructive micro x-ray fluorescence (µXRF) and quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) revealed lower content for nine elements in HCC and lesions compared to the liver. Non-destructive quantum cascade laser (QCL)-based infrared microspectroscopy visualized higher lipid, protein, and nucleic acid content in the liver compared to HCC, and glycogen accumulations in lesions. Matrix-assisted laser desorption/ionization-trapped ion mobility spectrometry-mass spectrometry (MALDI-TIMS-MS) unveiled individual lipid distributions to characterize HCC, connective and adjacent liver tissue. Detailed image segmentation was facilitated by (bisecting) k-means clustering and interactive clustering using uniform manifold approximation and projection (UMAP) embeddings

Daily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trialResearch in context

Summary: Background: Mucosal administration of monoclonal antibodies (mAbs) against respiratory pathogens is a promising alternative for systemic administration because lower doses are required for protection. Clinical development of mucosal mAbs is a highly active field yet clinical proof-of-concept is lacking. Methods: In this investigator-initiated, double-blind, randomized placebo-controlled trial, we evaluated intranasal palivizumab for the prevention of RSV infection in preterm infants (Dutch Trial Register NTR7378 and NTR7403). We randomized infants 1:1 to receive intranasal palivizumab (1 mg/mL) or placebo once daily during the RSV season. Any RSV infection was the primary outcome and RSV hospitalization was the key secondary outcome. The primary outcome was analyzed with a mixed effect logistic regression on the modified intention-to-treat population. Findings: We recruited 268 infants between Jan 14, 2019 and Jan 28, 2021, after which the trial was stopped for futility following the planned interim analysis. Adverse events were similar in both groups (22/134 (16.4%) palivizumab arm versus 26/134 (19.4%) placebo arm). There were 6 dropouts and 168 infants were excluded from the efficacy analyses due to absent RSV circulation during the SARS-CoV-2 pandemic. Any RSV infection was similar in infants in both groups (18/47 (38.3%) palivizumab arm versus 11/47 (23.4%) placebo arm; aOR 2.2, 95% CI 0.7–6.5). Interpretation: Daily intranasal palivizumab did not prevent RSV infection in late preterm infants. Our findings have important implications for the clinical development of mucosal mAbs, namely the necessity of timely interim analyses and further research to understand mucosal antibody half-life. Funding: Funded by the Department of Pediatrics, University Medical Centre Utrecht, the Netherlands