Why we need TI-Oriented Language Learning and Teaching

The teaching of foreign languages to students in Translation and Interpreting (TI) programmes should be framed within the field of Language for Specific Purposes (LSP). This would make it possible to pinpoint specific curricular content and methodological traits that contribute to the enhancement of the communicative competence and initial development of TI competences. This paper analyses the students' perspectives on L2 teaching in a TI programme and how it should be undertaken to best comply with the linguistic demands imposed by translation and interpreting. A thematic analysis of 117 open questionnaires returned by students from Austria, Slovenia and Spain identified five areas to which the students attribute particular importance, and which should be considered when developing TI-oriented curricula

An LSP Framework for Translation and Interpreting Pedagogy

In this article, we present a pedagogical framework for foreign language teaching in undergraduate translation and interpreting programmes. Within Translation Studies, many scholars support the idea that TILLT (Translation- and Interpreting-oriented Language Learning and Teaching) should be framed within the teaching of Languages for Specific Purposes (LSP), as students will use language as a professional tool in their professional lives. Based on insights from LSP research and practice, the area of Translation Studies dedicated to the development of language competence and expertise research, we have selected and described the key aspects for the development of professional language use in Translation and Interpreting pedagogy. We have then connected them in a framework to show how they interact and influence each other.  En este artículo presentaremos un marco pedagógico para la enseñanza de lenguas extranjeras en los programas de grado de Traducción e Interpretación. Dentro de los Estudios de Traducción, muchos estudiosos apoyan la idea de que TILLT (Aprendizaje y Enseñanza de Lenguas orientados a la Traducción e Interpretación) debería enmarcarse dentro de la enseñanza de lenguas con fines específicos (LFE), ya que los estudiantes utilizarán la lengua como herramienta profesional en su vida laboral. Basándonos en las aportaciones desde el ámbito de la investigación y la práctica de LFE, el área de los Estudios de Traducción dedicada al desarrollo de la competencia lingüística y la experiencia en investigación, hemos seleccionado y descrito los aspectos más importantes para el desarrollo del uso profesional de la lengua en la pedagogía de la traducción y la interpretación. A continuación, los hemos conectado en un marco para mostrar cómo interactúan y se influyen mutuamente

Translocation and Recovery Efforts for the Telkwa Caribou, Rangifer tarandus caribou, Herd in Westcentral British Columbia, 1997-2005

During 1997–1999, 32 Woodland Caribou (Rangifer tarandus caribou) were translocated from the Sustut Herd to the Telkwa Mountains in westcentral British Columbia to augment recovery of the Telkwa Caribou Herd. The animals were fitted with radiocollars and located during 1997–2000 to determine selection of habitat features and terrain variables. Six Caribou calves were also collared to determine causes and timing of calf mortality during summer 1999. Defining available habitat for newly translocated animals is often arbitrary and subjective, and we based the analyses on ranks for habitat use and availability as this is less sensitive to the inclusion or exclusion of a questionable resource. This method represents some loss of information but provides indications of the relative importance of various habitat types without classifying any as avoided. High elevation habitat (> 1700 masl) on moderate slopes (16 – 45°) received the highest ranks, as did “warm” (136 – 315°) aspects and forests > 250 years old. Three calves died shortly after birth. One calf appeared to have been killed by predation, likely by a Golden Eagle (Aquila chrysaetos), and one calf was abandoned by the cow. Cause of death for the third calf is unknown. To assess habitat use associated with calving we compared summer locations with data obtained throughout the rest of 1999 for eight cows with calves and eight without calves. We found significant difference in use of elevation during calving time, when cows with calves remained at high elevations and barren cows generally descended to lower elevation habitat. Surveys conducted in 2005, five years after the completion of the initial study, produced a count of approximately 90 Caribou. This suggests that in the short term, the translocation was successful in re-establishing a self-sustaining Caribou population in the Telkwa Mountains

Long-lasting injection of solar energetic electrons into the heliosphere

The main sources of solar energetic particle (SEP) events are solar flares and shocks driven by coronal mass ejections (CMEs). While it is generally accepted that energetic protons can be accelerated by shocks, whether or not these shocks can also efficiently accelerate solar energetic electrons is still debated. In this study we present observations of the extremely widespread SEP event of 26 Dec 2013. To the knowledge of the authors, this is the widest longitudinal SEP distribution ever observed together with unusually long-lasting energetic electron anisotropies at all observer positions. Further striking features of the event are long-lasting SEP intensity increases, two distinct SEP components with the second component mainly consisting of high-energy particles, a complex associated coronal activity including a pronounced signature of a shock in radio type-II observations, and the interaction of two CMEs early in the event. The observations require a prolonged injection scenario not only for protons but also for electrons. We therefore analyze the data comprehensively to characterize the possible role of the shock for the electron event. Remote-sensing observations of the complex solar activity are combined with in-situ measurements of the particle event. We also apply a Graduated Cylindrical Shell (GCS) model to the coronagraph observations of the two associated CMEs to analyze their interaction. We find that the shock alone is likely not responsible for this extremely wide SEP event. Therefore we propose a scenario of trapped energetic particles inside the CME-CME interaction region which undergo further acceleration due to the shock propagating through this region, stochastic acceleration, or ongoing reconnection processes inside the interaction region. The origin of the second component of the SEP event is likely caused by a sudden opening of the particle trap.Comment: Reproduced with permission from Astronomy & Astrophysics, \c{opyright} ES

Integrating genetic, neuropsychological and neuroimaging data to model early-onset obsessive compulsive disorder severity

We propose an integrative approach that combines structural magnetic resonance imaging data (MRI), diffusion tensor imaging data (DTI), neuropsychological data, and genetic data to predict early-onset obsessive compulsive disorder (OCD) severity. From a cohort of 87 patients, 56 with complete information were used in the present analysis. First, we performed a multivariate genetic association analysis of OCD severity with 266 genetic polymorphisms. This association analysis was used to select and prioritize the SNPs that would be included in the model. Second, we split the sample into a training set (N = 38) and a validation set (N = 18). Third, entropy-based measures of information gain were used for feature selection with the training subset. Fourth, the selected features were fed into two supervised methods of class prediction based on machine learning, using the leave-one-out procedure with the train- ing set. Finally, the resulting model was validated with the validation set. Nine variables were used for the creation of the OCD severity predictor, including six genetic polymorphisms and three variables from the neuropsychological data. The developed model classified child and adolescent patients with OCD by disease severity with an accuracy of 0.90 in the testing set and 0.70 in the validation sample. Above its clinical applicability, the combination of particular neuropsychological, neuroimaging, and genetic characteristics could enhance our under- standing of the neurobiological basis of the disorder

Inflammatory dysregulation of monocytes in pediatric patients with obsessive-compulsive disorder

BACKGROUND: Although the exact etiology of obsessive-compulsive disorder (OCD) is unknown, there is growing evidence of a role for immune dysregulation in the pathophysiology of the disease, especially in the innate immune system including the microglia. To test this hypothesis, we studied inflammatory markers in monocytes from pediatric patients with OCD and from healthy controls. METHODS: We determined the percentages of total monocytes, CD16+ monocytes, and classical (CD14highCD16-), intermediate (CD14highCD16low), and non-classical (CD14lowCD16high) monocyte subsets in 102 patients with early-onset OCD and in 47 healthy controls. Moreover, proinflammatory cytokine production (GM-CSF, IL-1β, IL-6, IL-8, and TNF-α) was measured by multiplex Luminex analysis in isolated monocyte cultures, in basal conditions, after exposure to lipopolysaccharide (LPS) to stimulate immune response or after exposure to LPS and the immunosuppressant dexamethasone. RESULTS: OCD patients had significantly higher percentages of total monocytes and CD16+ monocytes than healthy controls, mainly due to an increase in the intermediate subset but also in the non-classical monocytes. Monocytes from OCD patients released higher amounts of GM-CSF, IL-1β, IL-6, IL-8, and TNF-α than healthy controls after exposure to LPS. However, there were no significant differences in basal cytokine production or the sensitivity of monocytes to dexamethasone treatment between both groups. Based on monocyte subset distribution and cytokine production after LPS stimulation, patients receiving psychoactive medications seem to have an intermediate inflammatory profile, that is, lower than non-medicated OCD individuals and higher than healthy controls. CONCLUSIONS: These results strongly support the involvement of an enhanced proinflammatory innate immune response in the etiopathogenesis of early-onset OCD

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation

Obesity-induced insulin resistance is associated with both ectopic lipid deposition and chronic, low-grade adipose tissue inflammation. Despite their excess fat, obese individuals show lower fatty-acid oxidation (FAO) rates. This has raised the question of whether burning off the excess fat could improve the obese metabolic phenotype. Here we used human-safe nonimmunoreactive adeno-associated viruses (AAV) to mediate long-term hepatic gene transfer of carnitine palmitoyltransferase 1A (CPT1A), the key enzyme in fatty-acid β-oxidation, or its permanently active mutant form CPT1AM, to high-fat diet-treated and genetically obese mice. High-fat diet CPT1A- and, to a greater extent, CPT1AM-expressing mice showed an enhanced hepatic FAO which resulted in increased production of CO(2) , adenosine triphosphate, and ketone bodies. Notably, the increase in hepatic FAO not only reduced liver triacylglyceride content, inflammation, and reactive oxygen species levels but also systemically affected a decrease in epididymal adipose tissue weight and inflammation and improved insulin signaling in liver, adipose tissue, and muscle. Obesity-induced weight gain, increase in fasting blood glucose and insulin levels, and augmented expression of gluconeogenic genes were restored to normal only 3 months after AAV treatment. Thus, CPT1A- and, to a greater extent, CPT1AM-expressing mice were protected against obesity-induced weight gain, hepatic steatosis, diabetes, and obesity-induced insulin resistance. In addition, genetically obese db/db mice that expressed CPT1AM showed reduced glucose and insulin levels and liver steatosis. Conclusion: A chronic increase in liver FAO improves the obese metabolic phenotype, which indicates that AAV-mediated CPT1A expression could be a potential molecular therapy for obesity and diabetes

Comprehensive Characterization of Solar Eruptions with Remote and In-Situ Observations, and Modeling : The Major Solar Events on 4 November 2015

Solar energetic particles (SEPs) are an important product of solar activity. They are connected to solar active regions and flares, coronal mass ejections (CMEs), EUV waves, shocks, Type II and III radio emissions, and X-ray bursts. These phenomena are major probes of the partition of energy in solar eruptions, as well as for the organization, dynamics, and relaxation of coronal and interplanetary magnetic fields. Many of these phenomena cause terrestrial space weather, posing multiple hazards for humans and their technology from space to the ground. Since particular flares, shocks, CMEs, and EUV waves produce SEP events but others do not, since propagation effects from the low corona to 1 AU appear important for some events but not others, and since Type II and III radio emissions and X-ray bursts are sometimes produced by energetic particles leaving these acceleration sites, it is necessary to study the whole system with a multi-frequency and multi-instrument perspective that combines both in-situ and remote observations with detailed modeling of phenomena. This article demonstrates this comprehensive approach and shows its necessity by analyzing a trio of unusual and striking solar eruptions, radio and X-ray bursts, and SEP events that occurred on 4 November 2015. These events show both strong similarities and differences from standard events and each other, despite having very similar interplanetary conditions and only two flare sites and CME genesis regions. They are therefore major targets for further in-depth observational studies, and for testing both existing and new theories and models. We present the complete suite of relevant observations, complement them with initial modeling results for the SEPs and interplanetary magnetic connectivity, and develop a plausible scenario for the eruptions. Perhaps controversially, the SEPs appear to be reasonably modelled and evidence points to significant non-Parker magnetic fields. Based on the very limited modeling available, we identify the aspects that are and are not understood, and we discuss ideas that may lead to improved understanding of the SEP, radio, and space-weather events.Peer reviewe

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design

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