Functional clustering of yeast proteins from the protein-protein interaction network

BACKGROUND: The abundant data available for protein interaction networks have not yet been fully understood. New types of analyses are needed to reveal organizational principles of these networks to investigate the details of functional and regulatory clusters of proteins. RESULTS: In the present work, individual clusters identified by an eigenmode analysis of the connectivity matrix of the protein-protein interaction network in yeast are investigated for possible functional relationships among the members of the cluster. With our functional clustering we have successfully predicted several new protein-protein interactions that indeed have been reported recently. CONCLUSION: Eigenmode analysis of the entire connectivity matrix yields both a global and a detailed view of the network. We have shown that the eigenmode clustering not only is guided by the number of proteins with which each protein interacts, but also leads to functional clustering that can be applied to predict new protein interactions

Renewable energy from Cyanobacteria: energy production optimization by metabolic pathway engineering

The need to develop and improve sustainable energy resources is of eminent importance due to the finite nature of our fossil fuels. This review paper deals with a third generation renewable energy resource which does not compete with our food resources, cyanobacteria. We discuss the current state of the art in developing different types of bioenergy (ethanol, biodiesel, hydrogen, etc.) from cyanobacteria. The major important biochemical pathways in cyanobacteria are highlighted, and the possibility to influence these pathways to improve the production of specific types of energy forms the major part of this review

<i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-bidi-font-family:Mangal;mso-ansi-language:EN-GB; mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB">Dillenia indica</span></i><span style="font-size:11.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-bidi-font-family:Mangal;mso-ansi-language:EN-GB; mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB"> L. exhibited hematoprotective effects via modulation of antioxidant responsive enzymes</span>

433-439<span style="font-size:11.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-GB">The present studies were intended towards finding a suitable plant based natural product which can ameliorate the hematotoxicity encountered as adverse drug reactions (ADRs) in various therapeutic regimens. Dillenia indica (DI) is used in folklore and traditional medicine as general health enhancer. The aim of the study was to evaluate the hematoprotective effects of natural botanical, Dillenia indica (DI) ethanolic extract (DIEE), employing a Phenylhydrazine (Phz)-induced hematotoxicity model of Sprague Dawley (SD) rats. DIEE exhibited hematoprotective effects In vitro and <i style="mso-bidi-font-style: normal">In vivo. Solvent guided Fractionation studies revealed the presence of high amounts triterpenoids in DIEE. DIEE showed radical scavenging properties in DPPH radical scavenging assay. Mechanism based studies unveiled the positive effects of DIEE on antioxidant enzymes Superoxide dismutases 2 and 3 (SOD’s) and Nuclear erythroid 2 p45-related factor 1 (Nfer- 1) and Nuclear erythroid 2 p45-related factor 2 (Nfer-2) employing quantitative real time PCR. In toxicity studies in SD rats, DIEE imparted no toxicity. The results are of integral significance as, the study establishes the folklore and traditional medicine claims about the peremptory actions of DI.</span

Effect of Cr substitution on transport and magnetic ordering in Nd0.50Sr0.50Mn1-xCrxO3 (0.001 <= x <= 0.20)

Chromium substitution in the charge ordered compound Nd0.50Sr0.50MnO3 has been studied within the concentration range of 20% to examine its effect on magnetic and transport properties. It is found that the system comprises of three distinct magnetic phases whose percentage depends on the chromium concentration, the temperature and the external magnetic field. As the system is cooled, it changes from paramagnetic insulating type to a predominantly ferromagnetic metal (FM) and finally to a dominating anti-ferromagnetic insulating phase with A, CE or C-type of order depending on the chromium concentration. The appearance of three symmetrical loops in the hysteresis curve of M vs. H at 5 K for x = 0.01 indicates the simultaneous presence of C, A and FM type phases in the system. (C) 200