121 research outputs found
Anxiety, emotional processing and depression in people with multiple sclerosis.
BACKGROUND: Despite the high comorbidity of anxiety and depression in people with multiple sclerosis (MS), little is known about their inter-relationships. Both involve emotional perturbations and the way in which emotions are processed is likely central to both. The aim of the current study was to explore relationships between the domains of mood, emotional processing and coping and to analyse how anxiety affects coping, emotional processing, emotional balance and depression in people with MS. METHODS: A cross-sectional questionnaire study involving 189 people with MS with a confirmed diagnosis of MS recruited from three French hospitals. Study participants completed a battery of questionnaires encompassing the following domains: i. anxiety and depression (Hospital Anxiety and Depression Scale (HADS)); ii. emotional processing (Emotional Processing Scale (EPS-25)); iii. positive and negative emotions (Positive and Negative Emotionality Scale (EPN-31)); iv. alexithymia (Bermond-Vorst Alexithymia Questionnaire) and v. coping (Coping with Health Injuries and Problems-Neuro (CHIP-Neuro) questionnaire. Relationships between these domains were explored using path analysis. RESULTS: Anxiety was a strong predictor of depression, in both a direct and indirect way, and our model explained 48% of the variance of depression. Gender and functional status (measured by the Expanded Disability Status Scale) played a modest role. Non-depressed people with MS reported high levels of negative emotions and low levels of positive emotions. Anxiety also had an indirect impact on depression via one of the subscales of the Emotional Processing Scale ("Unregulated Emotion") and via negative emotions (EPN-31). CONCLUSIONS: This research confirms that anxiety is a vulnerability factor for depression via both direct and indirect pathways. Anxiety symptoms should therefore be assessed systematically and treated in order to lessen the likelihood of depression symptoms
The universal Glivenko-Cantelli property
Let F be a separable uniformly bounded family of measurable functions on a
standard measurable space, and let N_{[]}(F,\epsilon,\mu) be the smallest
number of \epsilon-brackets in L^1(\mu) needed to cover F. The following are
equivalent:
1. F is a universal Glivenko-Cantelli class.
2. N_{[]}(F,\epsilon,\mu)0 and every probability
measure \mu.
3. F is totally bounded in L^1(\mu) for every probability measure \mu.
4. F does not contain a Boolean \sigma-independent sequence.
It follows that universal Glivenko-Cantelli classes are uniformity classes
for general sequences of almost surely convergent random measures.Comment: 26 page
The Assouad dimension of randomly generated fractals
We consider several different models for generating random fractals including
random self-similar sets, random self-affine carpets, and fractal percolation.
In each setting we compute either the \emph{almost sure} or the \emph{Baire
typical} Assouad dimension and consider some illustrative examples. Our results
reveal a common phenomenon in all of our models: the Assouad dimension of a
randomly generated fractal is generically as big as possible and does not
depend on the measure theoretic or topological structure of the sample space.
This is in stark contrast to the other commonly studied notions of dimension
like the Hausdorff or packing dimension.Comment: 26 pages, 7 figures, v3 corrected error in the proof of Theorem 3.2
and sharpened results on exceptional set
The Traveling Salesman Problem: Low-Dimensionality Implies a Polynomial Time Approximation Scheme
The Traveling Salesman Problem (TSP) is among the most famous NP-hard
optimization problems. We design for this problem a randomized polynomial-time
algorithm that computes a (1+eps)-approximation to the optimal tour, for any
fixed eps>0, in TSP instances that form an arbitrary metric space with bounded
intrinsic dimension.
The celebrated results of Arora (A-98) and Mitchell (M-99) prove that the
above result holds in the special case of TSP in a fixed-dimensional Euclidean
space. Thus, our algorithm demonstrates that the algorithmic tractability of
metric TSP depends on the dimensionality of the space and not on its specific
geometry. This result resolves a problem that has been open since the
quasi-polynomial time algorithm of Talwar (T-04)
Keck Spectra of Brown Dwarf Candidates and a Precise Determination of the Lithium Depletion Boundary in the Alpha Persei Open Cluster
We have identified twenty-seven candidate very low mass members of the
relatively young Alpha Persei open cluster from a six square degree CCD imaging
survey. Based on their I magnitudes and the nominal age and distance to the
cluster, these objects should have masses less than 0.1 Msunif they are cluster
members. We have subsequently obtained intermediate resolution spectra of
seventeen of these objects using the Keck II telescope and LRIS spectrograph.
We have also obtained near-IR photometry for many of the stars. Our primary
goal was to determine the location of the "lithium depletion boundary" and
hence to derive a precise age for the cluster. We detect lithium with
equivalent widths greater than or equal to 0.4 \AA in five of the program
objects. We have constructed a color-magnitude diagram for the faint end of the
Alpha Persei main sequence. These data allow us to accurately determine the
Alpha Persei single-star lithium depletion boundary at M(I) = 11.47, M(Bol)
= 11.42, (R-I) = 2.12, spectral type M6.0. By reference to theoretical
evolutionary models, this converts fairly directly into an age for the Alpha
Persei cluster of 90 10 Myr. At this age, the two faintest of our
spectroscopically confirmed members should be sub-stellar (i.e., brown dwarfs)
according to theoretical models.Comment: Accepted Ap
Distance sets, orthogonal projections, and passing to weak tangents
The author is supported by a Leverhulme Trust Research Fellowship (RF-2016-500).We consider the Assouad dimension analogues of two important problems in geometric measure theory. These problems are tied together by the common theme of âpassing to weak tangentsâ. First, we solve the analogue of Falconerâs distance set problem for Assouad dimension in the plane: if a planar set has Assouad dimension greater than 1, then its distance set has Assouad dimension 1. We also obtain partial results in higher dimensions. Second, we consider how Assouad dimension behaves under orthogonal projection. We extend the planar projection theorem of Fraser and Orponen to higher dimensions, provide estimates on the (Hausdorff) dimension of the exceptional set of projections, and provide a recipe for obtaining results about restricted families of projections. We provide several illustrative examples throughout.PostprintPeer reviewe
DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France
We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39â3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18â0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon
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