Demand and Distance: Evidence on Cross-Border Shopping

While many studies have documented deviations from the Law of One Price in international settings, evidence is scarce on the extent to which consumers take advantage of price differentials and engage in cross border shopping. We use data from 287 Swedish municipalities to estimate how responsive alcohol sales are to foreign prices, and relate the sensitivity to the location’s distance to the border. Typical results suggest that the elasticity with respect to the foreign price is around 0.4 in the border region; moving 200 (400) kilometers inland reduces it to 0.2 (0.1). Given that cross country price differences for alcohol and other products are often caused by taxes, our evidence has implications for the debate on tax competition/harmonization.Law of one price; tax competition; tax harmonization; cross border shopping; European integration.

Demand and distance: Evidence on cross-border shopping

While many studies have documented deviations from the Law of One Price in international settings, evidence is scarce on the extent to which consumers take advantage of price differentials and engage in cross border shopping. We use data from 287 Swedish municipalities to estimate how responsive alcohol sales are to foreign prices, and relate the sensitivity to the location's distance to the border. Typical results suggest that the elasticity with respect to the foreign price is around 0.4 in the border region; moving 200 (400) kilometers inland reduces it to 0.2 (0.1). Given that cross country price differences for alcohol and other products are often caused by taxes, our evidence has implications for the debate on tax competition/harmonization

A Scoping Review of Pressure Measurements in Prosthetic Sockets of Transfemoral Amputees during Ambulation:Key Considerations for Sensor Design

Sensor systems to measure pressure at the stump–socket interface of transfemoral amputees are receiving increasing attention as they allow monitoring to evaluate patient comfort and socket fit. However, transfemoral amputees have many unique characteristics, and it is unclear whether existing research on sensor systems take these sufficiently into account or if it is conducted in ways likely to lead to substantial breakthroughs. This investigation addresses these concerns through a scoping review to profile research regarding sensors in transfemoral sockets with the aim of advancing and improving prosthetic socket design, comfort and fit for transfemoral amputees. Publications found from searching four scientific databases were screened, and 17 papers were found relating to the aim of this review. After quality assessment, 12 articles were finally selected for analysis. Three main contributions are provided: a de facto methodology for experimental studies on the implications of intra-socket pressure sensor use for transfemoral amputees; the suggestion that associated sensor design breakthroughs would be more likely if pressure sensors were developed in close combination with other types of sensors and in closer cooperation with those in possession of an in-depth domain knowledge in prosthetics; and that this research would be facilitated by increased interdisciplinary cooperation and open research data generation.QC 20210810SocketSens

Surgeon age in relation to patients’ long-term survival after gastrectomy for gastric adenocarcinoma: nationwide population-based cohort study

Background: Increasing surgeon age may influence patient outcomes after complex procedures due to gained experience but also decreased technical and cognitive abilities. This study aimed to clarify whether surgeon age influences patients’ long-term survival after gastrectomy for gastric adenocarcinoma. Methods: Population-based cohort study including all patients who underwent open and curatively intended gastrectomy for gastric adenocarcinoma between 2006 and 2015 in Sweden, with follow-up throughout 2020. Surgeon age, categorized into three equal-sized groups (tertiles), was assessed in relation to 5-year all-cause mortality rate (main outcome) and 5-year disease-specific death (secondary outcome) using multivariable Cox regression adjusted for patient age, sex, education, co-morbidity, pathological tumour stage, tumour sublocation and neoadjuvant therapy. Lymph node yield, resection margin status, in-hospital complications and annual surgeon volume of gastrectomy were considered potential mediators. Results: Among 1647 patients, the 5-year all-cause mortality rate was increased for surgeon age ≥55 years (adjusted HR 1.21, 95% c.i. 1.04 to 1.41) and borderline elevated for age 47–54 years (HR 1.16, 95% c.i. 0.99 to 1.36), compared with age ≤46 years. Five-year disease-specific death was increased for surgeon age ≥55 years (HR 1.25, 95% c.i. 1.06 to 1.48) and 47–54 years (HR 1.22, 95% c.i. 1.02 to 1.44), compared with age ≤46 years. The associations attenuated and became statistically non-significant after adjustment for lymph node yield, resection margin status and complications. Conclusion: Surgeon age ≥47 years might be associated with worse long-term survival in patients who undergo gastrectomy for gastric adenocarcinoma, possibly mediated in part by differences in lymph node yield, resection margin status and complications

Towards the Automated Qualification of Tool Chain Design

Abstract. The development of safety-critical embedded systems is supported by a number of development tools, which are increasingly integrated into automated tool chains. Safety standards require these tool chains to be qualified, which is costly and requires a large effort. To reduce cost and effort tool chains can be composed of pre-qualified tools and then themselves pre-qualified by identifying the parts of tool chain software that have an impact on safety more exactly. In this paper we propose the use of a modeling language to describe this tool chain composition. This allows us to reduce effort even further by automatically analyzing the tool chain model for safety issues. It also promises to reduce the effort and cost of later steps in the deployment of the tool chain by formalizing the communication of safety issues and automating the generation of code for tool chain software

Correlations between RNA and protein expression profiles in 23 human cell lines

<p>Abstract</p> <p>Background</p> <p>The Central Dogma of biology holds, in famously simplified terms, that DNA makes RNA makes proteins, but there is considerable uncertainty regarding the general, genome-wide correlation between levels of RNA and corresponding proteins. Therefore, to assess degrees of this correlation we compared the RNA profiles (determined using both cDNA- and oligo-based microarrays) and protein profiles (determined immunohistochemically in tissue microarrays) of 1066 gene products in 23 human cell lines.</p> <p>Results</p> <p>A high mean correlation coefficient (0.52) was obtained from the pairwise comparison of RNA levels determined by the two platforms. Significant correlations, with correlation coefficients exceeding 0.445, between protein and RNA levels were also obtained for a third of the specific gene products. However, the correlation coefficients between levels of RNA and protein products of specific genes varied widely, and the mean correlations between the protein and corresponding RNA levels determined using the cDNA- and oligo-based microarrays were 0.25 and 0.20, respectively.</p> <p>Conclusion</p> <p>Significant correlations were found in one third of the examined RNA species and corresponding proteins. These results suggest that RNA profiling might provide indirect support to antibodies' specificity, since whenever a evident correlation between the RNA and protein profiles exists, this can sustain that the antibodies used in the immunoassay recognized their cognate antigens.</p

Rapid Integration of CPS Security and Safety

The security and safety of Cyber-Physical Systems (CPS) often influence each other. Ensuring that this does not have negative implications might require a large and rigorous effort during the development of CPS. However, early in the life-cycle, quick feedback can be valuable helping security and safety engineers to understand how seemingly trivial design choices in their domain may have unacceptable implications in the other. We propose the Cyber Risk Assessment Framework (CRAF) for this purpose. The CRAF is based on openly available and widely used taxonomies from the safety and security domains, and a unique mapping of where loss of data security may impact aspects of data with safety implications. This paper represents the first time these different elements have been brought together into a single framework with an associated process. Through examples from within our organisations we show how this framework can be put to good use

Promotion of manual drilling in Guinea Bissau: mapping suitable zones and estimating the potential

Guinea Bissau has made large strides in water supply, but still 35% of villages have no access to safe water. UNICEF is promoting alternative solutions to ensure a proper water supply in these small communities, for example manual drilling. For these reason a mapping study to identify suitable zones for these techniques has been carried out in 2016, using existing groundwater data and the experience from local experts. 88% of Guinea Bissau is considered with feasible hydrologeogical conditions for manual drilling. In 63% of the regions where this technique is applicable, it is adequate for villages of small-medium size. Taking into consideration the results of this study, it seems evident that the promotion of manual drilling could be a valid alternative to improve the situation of access to safe water especially in rural areas

A global view of protein expression in human cells, tissues, and organs

Defining the protein profiles of tissues and organs is critical to understanding the unique characteristics of the various cell types in the human body. In this study, we report on an anatomically comprehensive analysis of 4842 protein profiles in 48 human tissues and 45 human cell lines. A detailed analysis of over 2 million manually annotated, high-resolution, immunohistochemistry-based images showed a high fraction (>65%) of expressed proteins in most cells and tissues, with very few proteins (<2%) detected in any single cell type. Similarly, confocal microscopy in three human cell lines detected expression of more than 70% of the analyzed proteins. Despite this ubiquitous expression, hierarchical clustering analysis, based on global protein expression patterns, shows that the analyzed cells can be still subdivided into groups according to the current concepts of histology and cellular differentiation. This study suggests that tissue specificity is achieved by precise regulation of protein levels in space and time, and that different tissues in the body acquire their unique characteristics by controlling not which proteins are expressed but how much of each is produced