3 research outputs found
Corrosion behavior of mild steel and SS 304L in presence of dissolved nickel under aerated and deaerated conditions
In-Situ Electrochemical Corrosion Behavior of Nickel-Base 718 Alloy Under Various CO2 Partial Pressures at 150 and 205 °C in NaCl Solution
Potential pharmacological treatments of prosthetic joint loosening
We are beginning to understand the biological events that lead to aseptic loosening of total joint prostheses. Particles of wear, mostly liberated from the articulating surfaces of implants, are phagocytosed by macrophages and induce the release of inflammatory mediators (such as interleukin-1, tumour necrosis factor, interleukin-6 and prostaglandin E2) or cause cell death. These biological responses are thought to cause the bone loss that leads to prosthetic loosening. Drugs that suppress inflammatory mediators are successfully used to treat inflammatory diseases. Certain drugs can also reduce the corrosion of metal wear particles inside macrophages which enhances mediator release or cell death. Here we consider the prospect that these pharmacological treatments may enhance the long-term survival of implants. © 1995 Kluwer Academic Publishers