3 research outputs found
Recommended from our members
Relationship between serum anti-heat shock protein 27 antibody levels and obesity
Background
Heat shock protein 27 (HSP27) is an intracellular molecular chaperone that is expressed at high levels following the exposure of cells to environmental stressors such as heat, toxins, and free radicals. High levels of HSP antigens and antibody titers have been reported in several conditions including cardiovascular disease and cancers. We measured serum anti-HSP27 antibody levels in 993 subjects and assessed the associations between serum anti-HSP27 antibody levels and demographic characteristics including coronary risk factors.
Methods
A total of 993 subjects were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Demographic, clinical, and biochemical parameters and serum anti-HSP27 antibody titers were determined in all the subjects.
Results
Serum anti-HSP27 antibody levels increased with increasing age in men. No significant differences in levels were detected between men and women. Serum anti-HSP27 antibody levels were significantly higher in obese subjects than in nonobese subjects (P = 0.046); however, no significant influence of smoking status was observed. Moreover, serum anti-HSP27 antibody titers were positively associated with age, body mass index, waist/hip ratio, the presence of diabetes mellitus, nonsmoking habit, serum triglycerides, cholesterol, and high-sensitivity c-reactive protein.
Conclusion
We have found that serum anti-HSP27 antibody titers are related to several cardiovascular risk factors, necessitating further studies on the value of this emerging marker for risk stratification
Study of diagnostic values of serum thyroid hormone and creatinine in acute renal transplant rejection
Background and Aim: Renal transplantation is one of the main treatments of chronic renal disease that creates a more optimal condition and reduces the risk of fatality. The most common reason behind the functional problems of transplanted kidney in its initial postoperation phase is acute renal transplant rejection, the timely diagnosis of which would help the doctors, begin the required treatments immediately to maintain renal functionality, and prevent further irrecoverable damages. Therefore, identifying the variables which are accurate and reliable predictors of renal transplant rejection can be hugely beneficial. Materials and Methods: In this historical cohort study, 87 nondiabetic patients with renal failure who had received treatments at Kidney Transplantation Department of Imam Reza and Ghaem Hospitals of Mashhad, Iran, were selected and their demographic and clinical characteristics were collected. Among these data, creatinine, fasting blood sugar (FBS) and serum insulin, thyroid-stimulating hormone (TSH), and T3 and T4 hormones were measured four times after the transplant operation. Data were analyzed using SAS 9.3 and MedCalc 13 software. First, the missing data were imputed with appropriate imputation methods, and then using logistic regression and area under receiver operating characteristic (ROC) curve, the most important detectors of acute renal transplant rejection were determined. Significance level (α) was set at 0.01. Results: Using logistic regression analysis and drawing ROC curves for average value of four measurements, the effect of serum creatinine and T4 hormone was found statistically significant (P < 0.01). Conclusion: Results showed that among six variables that were studied (creatinine, FBS, insulin, TSH, T3, and T4), serum creatinine and T4 hormone were statistically significant and also were the most important of acute renal transplant rejection