USING RESTORATION-ORIENTED COPING AND THE DUAL PROCESS MODEL WITH BEREAVED UNDERGRADUATES

Approximately 60% of college seniors lost at least one family member or friend since beginning college (Cox, Dean, & Kowalski, 2015). Research reveals that bereaved students are more likely than their nonbereaved peers to struggle with academic problems and attrition (Cousins, Servaty-Seib & Lockman, 2017), highlighting the importance of identifying protective factors for this group of individuals. Researchers have identified restoration-oriented coping as a helpful coping mechanism in other samples (Caserta & Lund, 2007; Caserta, Lund, Utza, & de Vries, 2009). Despite qualitative evidence suggesting bereaved undergraduates often employ restoration-oriented coping, no research has formally assessed the effects of restoration-oriented coping in a bereaved undergraduate sample. This study assessed the effects of restoration-oriented coping on students’ (N=420; 68.8% female; 46.7% white) psychological well-being in a longitudinal design. Data were part of a larger study (“Spit 4 Science”) assessing the development of substance use and emotional health outcomes in college students. Students were assessed annually; those who reported a loss, had pre-, and post-loss data were included in analysis. Hierarchical multiple linear regressions were conducted and showed restoration-oriented coping was predictive of better psychological well-being and that this relationship was strengthened by social support quality. Extraversion was also predictive of better psychological well-being, while openness and neuroticism were related to poorer psychological well-being. Moreover, neuroticism mediated the relationship between distress at indication of loss and post-loss follow-up. Further research of restoration-oriented coping efforts among bereaved undergraduates is warranted. Additional resources and support may help to keep students engaged following a loss

Molecular Characterization of a Patient Presumed to Have Prader-Willi Syndrome

Prader-Willi syndrome (PWS) is caused by the loss of RNA expression from an imprinted region on chromosome 15 that includes SNRPN, SNORD115, and SNORD116. Currently, there are no mouse models that faithfully reflect the human phenotype and investigations rely on human post-mortem material. During molecular characterization of tissue deposited in a public brain bank from a patient diagnosed with Prader-Willi syndrome, we found RNA expression from SNRPN, SNORD115, and SNORD116 which does not support a genetic diagnosis of Prader-Willi syndrome. The patient was a female, Caucasian nursing home resident with history of morbid obesity (BMI 56.3) and mental retardation. She died at age of 56 from pulmonary embolism. SNORD115 and SNORD116 are unexpectedly stable in post mortem tissue and can be used for post-mortem diagnosis. Molecular characterization of PWS tissue donors can confirm the diagnosis and identify those patients that have been misdiagnosed

Clear lens phacoemulsification in the anterior lenticonus due to Alport Syndrome: two case reports

<p>Abstract</p> <p>Introduction</p> <p>Alport Syndrome has a prevalence of 1 case per 5,000 people and 85% of patients have the X-linked form, where affected males develop renal failure and usually have high-tone sensorineural deafness by age 20. The main abnormality is deficient synthesis of type IV collagen, the main component of basement membranes. Common ocular abnormalities of this syndrome consist of dot-and-fleck retinopathy, posterior polymorphous corneal dystrophy, and anterior lenticonus, but other ocular defects such as cataracts, posterior lenticonus, and retinal detachments have also been reported.</p> <p>Case presentation</p> <p>We report two cases of anterior lenticonus due to Alport Syndrome and describe clear lens phacoemulsification and foldable intraocular lens implantation as an effective and safe refractive procedure in the four eyes of these two patients.</p> <p>Conclusion</p> <p>All four eyes of the two patients were in good condition after surgery and achieved satisfactory optical and visual results and had no remarkable complications at six-months follow-up. Clear lens phacoemulsification with foldable intraocular lens implantation can be used as an efficient and safe procedure for vision disorders in these patients.</p

Prevalence of Trichomonas vaginalis and Coinfection with Chlamydia trachomatis and Neisseria gonorrhoeae in the United States as Determined by the Aptima Trichomonas vaginalis Nucleic Acid Amplification Assay

Our aim was to determine Trichomonas vaginalis prevalence using the Aptima Trichomonas vaginalis assay (ATV; Gen-Probe) and the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae coinfections in U.S. women undergoing screening for C. trachomatis/N. gonorrhoeae. Discarded urogenital samples from 7,593 women (18 to 89 years old) undergoing C. trachomatis/N. gonorrhoeae screening using the Aptima Combo 2 assay (Gen-Probe) in various clinical settings were tested with ATV. Overall, T. vaginalis, C. trachomatis, and N. gonorrhoeae prevalences were 8.7%, 6.7%, and 1.7%, respectively. T. vaginalis was more prevalent than C. trachomatis or N. gonorrhoeae in all age groups except the 18- to 19-year-old group. The highest T. vaginalis prevalence was in women ≥40 years old (>11%), while the highest C. trachomatis prevalence (9.2%) and N. gonorrhoeae prevalence (2.2%) were in women C. trachomatis/T. vaginalis, 0.61% for C. trachomatis/N. gonorrhoeae and N. gonorrhoeae/T. vaginalis, and 0.24% for C. trachomatis/N. gonorrhoeae/T. vaginalis and highest in women T. vaginalis prevalence differed by race/ethnicity, with the highest prevalence in black women (20.2%). T. vaginalis prevalence ranged from 5.4% in family planning clinics to 22.3% in jails. Multivariate analysis determined that ages of ≥40 years, black race, and patient locations were significantly associated with T. vaginalis infection. T. vaginalis is the most common sexually transmitted infection (STI) in women of >40 years, while C. trachomatis and N. gonorrhoeae prevalence is lowest in that age group. Higher T. vaginalis prevalence in women of >40 years is probably attributed to the reason for testing, i.e., symptomatic status versus routine screening in younger women. Coinfections were relatively low. High T. vaginalis prevalence in all age groups suggests that women screened for C. trachomatis/N. gonorrhoeae, whether asymptomatic or symptomatic, should be screened for T. vaginalis

A Sensitive Branched DNA HIV-1 Signal Amplification Viral Load Assay with Single Day Turnaround

Branched DNA (bDNA) is a signal amplification technology used in clinical and research laboratories to quantitatively detect nucleic acids. An overnight incubation is a significant drawback of highly sensitive bDNA assays. The VERSANT® HIV-1 RNA 3.0 Assay (bDNA) (“Versant Assay”) currently used in clinical laboratories was modified to allow shorter target incubation, enabling the viral load assay to be run in a single day. To dramatically reduce the target incubation from 16–18 h to 2.5 h, composition of only the “Lysis Diluent” solution was modified. Nucleic acid probes in the assay were unchanged. Performance of the modified assay (assay in development; not commercially available) was evaluated and compared to the Versant Assay. Dilution series replicates (>950 results) were used to demonstrate that analytical sensitivity, linearity, accuracy, and precision for the shorter modified assay are comparable to the Versant Assay. HIV RNA-positive clinical specimens (n = 135) showed no significant difference in quantification between the modified assay and the Versant Assay. Equivalent relative quantification of samples of eight genotypes was demonstrated for the two assays. Elevated levels of several potentially interfering endogenous substances had no effect on quantification or specificity of the modified assay. The modified assay with drastically improved turnaround time demonstrates the viability of signal-amplifying technology, such as bDNA, as an alternative to the PCR-based assays dominating viral load monitoring in clinical laboratories. Highly sensitive bDNA assays with a single day turnaround may be ideal for laboratories with especially stringent cost, contamination, or reliability requirements

The artificial immune system approach for smart air-conditioning control

Biologically inspired computing that looks to nature and biology for inspiration is a revolutionary change to our thinking about solving complex computational problems. It looks into nature and biology for inspiration rather than conventional approaches. The Human Immune System with its complex structure and the capability of performing pattern recognition, self-learning, immune-memory, generation of diversity, noise tolerance, variability, distributed detection and optimisation-is one area that has been of strong interest and inspiration for the last decade. An air conditioning system is one example where immune principles can be applied. This paper describes new computational technique called Artificial Immune System that is based on immune principles and refined for solving engineering problems. The presented system solution applies AIS algorithms to monitor environmental variables in order to determine how best to reach the desired temperature, learn usage patterns and predict usage needs. The aim of this paper is to explore the AIS-based artificial intelligence approach and its impact on energy efficiency. It will examine, if AIS algorithms can be integrated within a Smart Air Conditioning System as well as analyse the impact of such a solution

Group-work teaching and learning involving 3 Time Zones (3TZ) model of collaboration in the global workspace

This paper discusses concepts of group-work teaching and learning of practice based subjects within ICT engineering programs using 3 Time Zones (3TZ) collaborative, global workspace environment. The methodology intends to explore and evaluate a new collaborative framework for teaching system analysis and design, as well as software engineering in higher education, using new convergent technologies. The project is compatible with a model of teaching and learning that involves a blend of three interrelated features: an integrated exposure to professional practice and multidisciplinary skills, a practice situated in a global environment, as well as a research inspired and integrated learning. © 2012 IEEE