ウラシルDNAグリコシラーゼのnoncanonicalな機能によるS-領域超変異と クラススイッチ組み換えに対する異なる制御

The final publication is available at http://dx.doi.org/10.1073/pnas.1402391111. Ashraf S. Yousif, Andre Stanlie, Samiran Mondal, Tasuku Honjo, and Nasim A. Begum. Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase. PNAS 2014 111 (11) E1016-E1024; published ahead of print March 3, 2014.京都大学0048新制・課程博士博士(医科学)甲第18464号医科博第55号新制||医科||4(附属図書館)31342京都大学大学院医学研究科医科学専攻(主査)教授 清水 章, 教授 萩原 正敏, 教授 武田 俊一学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Detection of schistosomiasis antibodies in urine patients as a promising diagnostic maker

AbstractObjectiveTo determine secreted antischistosoma antibodies in urine and to discern the epidemiological situation of schistosomiasis in the agricultural field labourers'camps city in the Gezira State-central Sudan.MethodsTotal of 66 urine and 66 serum paired samples were collected from those who confirmed parasitologically positive and negative with schistosomiasis from the two camps. Samples were tested using ELISA technique to measure and compare the immunoglobulin G (IgG) levels in serum and urine samples of schistosomiasis patients.ResultsThe overall prevalence of S. mansoni and S. haematobium was 53.8% and 15.4%, while the intensity were (2.04 GMEC) and (0.9 GMEC) respectively. The relative percentage of positive IgG individulas in urine was 92.40% where as 96.97% in serum. Statistically no significant difference between the IgG levels in serum and urine samples was observed.ConclusionsThis study shows that the detection of secreted IgG antibodies in urine can substitute serum for diagnosis of schistosomiasis