Overview of recent mountain-building events in the Big Bend region, West Texas and Northern Mexico

The terrain of the Big Bend region, as well as locations of many ore bodies, hot springs, and the Rio Grande River, mostly result from two mountain-building events: Basin and Range extension that continues today, but also Rocky Mountain (or “Laramide”) contraction that ended 50 million years ago. Both events continued for tens of millions of years, producing complex arrangements of folds and faults throughout broad, overlapping zones extending from southern Mexico into Canada. Laramide contraction and Basin and Range extension are caused, at least in part, by changing plate interactions along the western margin of the North American plate. Two compilation maps of the Big Bend region, one showing Laramide structures and one showing Basin and Range structures, summarize current understanding. Panoramic photographs illustrate well-exposed structures in Big Bend National Park. An extensive reference list compiles work on Laramide and Basin and Range structures. Work to date, which includes recent detailed mapping in two small areas, emphasizes several points: a) Laramide structures in the Big Bend region include thick-skinned basement uplifts and coeval thin-skinned thrust belts, b) Map-scale and outcrop-scale folds formed during Basin and Range extension as well as during Laramide contraction, and c) Long-lived fault zones moved repeatedly during Laramide contraction and Basin and Range extension

Capacity building lessons from a decade of transitional settlement and shelter

This paper examines 23 recent case studies of post‐disaster settlement and shelter across Africa, Asia, and Latin America to provide examples of implementing transitional settlement and shelter as a process and how to build more capacity for such programmes. The case studies are examined by using a four‐part framework: (i) Safety, security, and livelihoods; (ii) the question “Transition to what?” in order to understand better how to connect post‐disaster programmes to permanent communities and housing; (iii) fairness and equity; and (iv) connecting relief and development, which also explores root causes of vulnerability. The main lessons identify six specific activities that should be highlighted for capacity building in transitional settlement and shelter: site selection, good governance, participatory and consultative processes, land ownership, logistics, and monitoring and evaluation. Santruka Šiame darbe analizuojami 23 neseniai atliktu nelaimes ištiktu žmoniu apgyvendinimo ir prieglaudu jiems suteikimo Afrikoje, Azijoje ir Lotynu Amerikoje tyrimu rezultatai, pateikiami efektyvaus aprūpinimo laikinosiomis gyvenamosiomis vietomis ir prieglaudomis programu igyvendinimo pavyzdžiai, patariama, kaip didinti šiu programu potenciala. Tyrimu rezultatai nagrinejami remiantis keturiu daliu struktūra: 1) saugumas, apsauga ir pragyvenimo šaltinis; 2) klausimas “Jei laikinas, tai kas po to?”, siekis ištikus nelaimei vykdomas apgyvendinimo programas susieti su pastoviomis bendruomenemis ir nuolatiniu būstu; 3) teisingumas ir lygybe; 4) paramos ir pletros sasaja, pagrindines pažeidžiamumo priežastys. Išskiriamos šešios konkrečios veiklos rūšys, kurias reiketu akcentuoti didinat aprūpinimo laikinosiomis gyvenamosiomis vietomis ir prieglaudu suteikimo potenciala: vietos parinkimas, geras valdymas, dalyvavimo ir konsultavimo procesai, žemes nuosavybe, logistika, stebejimas bei vertinimas. First Publish Online: 18 Oct 201

Volume 02

Introduction from Dean Dr. Charles Ross Mike\u27s Nite: New Jazz for an Old Instrument by Joseph A. Mann Investigation of the use of Cucumis Sativus for Remediation Of Chromium from Contaminated Environmental Matrices: An Interdisciplinary Instrumental Analysis Project by Kathryn J. Greenly, Scott E. Jenkins, and Andrew E. Puckette Development of GC-MS and Chemometric Methods for the Analysis of Accelerants in Arson Cases by Scott Jenkins Building and Measuring Scalable Computing Systems by Daniel M. Honey and Jeffery P. Ravenhorst Nomini Hall: A Case Study in the Use of Archival Resources as Guides for Excavation at An Archaeological Site by Jamie Elizabeth Mesrobian Two Stories: In Ohio and How to Stay Out of the Brazilian Army by Thomas Scott Forgerson des Hommes/Stealing the Steel in Zola\u27s Men by Jay Crowell Paul Gauguin\u27s Escape into Primitivism by Sarah Spangenberg Lee Krasner, Abstract Expressionist by Amy S. Eason Artist Book “Paris” by Kenny Wolfe Artist Book “Sequence of Every Day” by Liz Hale Artist Book “Apple Tree” by Rachel Bouchard Artist Book “Not so Pretty in Pink” by Will Semonco Artist Book “Look into the Moon” by Carley York Artist Books “Extra” and “Green” by Ryan Higgenbothom Artist Book “Re-growing Appalachia” by Adrienne Heinbaugh Artist Books “Cheeziest”, “Uh-oh” and “The Girl with the Glasses” by Melissa Dorton “Self-Reflection” by Madeline Hunter Artist Book “The Princess and the Frog” by June Ashmore “Hunter’s Niche” and “The Wild” by Clark Barkley “To Thine Own Self be True” by Jay Haley “Not Funny” Ten-Minute Play Festiva

On the finite temperature λφ4\lambda\varphi^{4} and Gross-Neveu models. Is there a first order phase transition in (λφ4)D=3(\lambda\varphi^{4})_{D=3}?

We study the behavior of two diferent models at finite temperature in a $D$-dimensional spacetime. The first one is the $\lambda\varphi^{4}$ model and the second one is the Gross-Neveu model. Using the one-loop approximation we show that in the $\lambda\varphi^{4}$ model the thermal mass increase with the temperature while the thermal coupling constant decrese with the temperature. Using this facts we establish that in the $(\lambda\varphi^{4})_{D=3}$ model there is a temperature $\beta^{-1}_{\star}$ above which the system can develop a first order phase transition, where the origin corresponds to a metastable vacuum. In the massless Gross-Neveu model, we demonstrate that for $D=3$ the thermal correction to the coupling constant is zero. For $D\neq 3$ our results are inconclusive. Pacs numbers: 11.10.Ef, 11.10.G

Preterm birth associated with maternal fine particulate matter exposure : A global, regional and national assessment

Reduction of preterm births (< 37 completed weeks of gestation) would substantially reduce neonatal and infant mortality, and deleterious health effects in survivors. Maternal fine particulate matter (PM2.5) exposure has been identified as a possible risk factor contributing to preterm birth. The aim of this study was to produce the first estimates of ambient PM2.5-associated preterm births for 183 individual countries and globally. To do this, national, population-weighted, annual average ambient PM2.5 concentration, preterm birth rate and number of livebirths were combined to calculate the number of PM2.5-associated preterm births in 2010 for 183 countries. Uncertainty was quantified using Monte-Carlo simulations, and analyses were undertaken to investigate the sensitivity of PM2.5-associated preterm birth estimates to assumptions about the shape of the concentration-response function at low and high PM2.5 exposures, inclusion of provider-initiated preterm births, and exposure to indoor air pollution. Globally, in 2010, the number of PM2.5-associated preterm births was estimated as 2.7 million (1.8–3.5 million, 18% (12–24%) of total preterm births globally) with a low concentration cut-off (LCC) set at 10 μg m− 3, and 3.4 million (2.4–4.2 million, 23% (16–28%)) with a LCC of 4.3 μg m− 3. South and East Asia, North Africa/Middle East and West sub-Saharan Africa had the largest contribution to the global total, and the largest percentage of preterm births associated with PM2.5. Sensitivity analyses showed that PM2.5-associated preterm birth estimates were 24% lower when provider-initiated preterm births were excluded, 38–51% lower when risk was confined to the PM2.5 exposure range in the studies used to derive the effect estimate, and 56% lower when mothers who live in households that cook with solid fuels (and whose personal PM2.5 exposure is likely dominated by indoor air pollution) were excluded. The concentration-response function applied here derives from a meta-analysis of studies, most of which were conducted in the US and Europe, and its application to the areas of the world where we estimate the greatest effects on preterm births remains uncertain. Nevertheless, the substantial percentage of preterm births estimated to be associated with anthropogenic PM2.5 (18% (13%–24%) of total preterm births globally) indicates that reduction of maternal PM2.5 exposure through emission reduction strategies should be considered alongside mitigation of other risk factors associated with preterm births

Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS

The formation of acquired drug resistance is a major reason for the failure of anti-cancer therapies after initial response. Here, we introduce a novel model of acquired oxaliplatin resistance, a sub-line of the non-MYCN-amplified neuroblastoma cell line SK-N-AS that was adapted to growth in the presence of 4000 ng/mL oxaliplatin (SK-N-ASrOXALI4000). SK-N-ASrOXALI4000 cells displayed enhanced chromosomal aberrations compared to SK-N-AS, as indicated by 24-chromosome fluorescence in situ hybridisation. Moreover, SK-N-ASrOXALI4000 cells were resistant not only to oxaliplatin but also to the two other commonly used anti-cancer platinum agents cisplatin and carboplatin. SK-N-ASrOXALI4000 cells exhibited a stable resistance phenotype that was not affected by culturing the cells for 10 weeks in the absence of oxaliplatin. Interestingly, SK-N-ASrOXALI4000 cells showed no cross resistance to gemcitabine and increased sensitivity to doxorubicin and UVC radiation, alternative treatments that like platinum drugs target DNA integrity. Notably, UVC-induced DNA damage is thought to be predominantly repaired by nucleotide excision repair and nucleotide excision repair has been described as the main oxaliplatin-induced DNA damage repair system. SK-N-ASrOXALI4000 cells were also more sensitive to lysis by influenza A virus, a candidate for oncolytic therapy, than SK-N-AS cells. In conclusion, we introduce a novel oxaliplatin resistance model. The oxaliplatin resistance mechanisms in SK-N-ASrOXALI4000 cells appear to be complex and not to directly depend on enhanced DNA repair capacity. Models of oxaliplatin resistance are of particular relevance since research on platinum drugs has so far predominantly focused on cisplatin and carboplatin

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

The sociology of cancer: a decade of research

Biomedicine is often presented as the driving force behind improvements in cancer care, with genomics the latest innovation poised to change the meaning, diagnosis, treatment, prevention and lived experience of cancer. Reviewing sociological analyses of a diversity of patient and practitioner experiences and accounts of cancer during the last decade (2007–17), we explore the experiences of, approaches to and understandings of cancer in this period. We identify three key areas of focus: (i) cancer patient experiences and identities; (ii) cancer risk and responsibilities and (iii) bioclinical collectives. We explore these sociological studies of societal and biomedical developments and how sociologists have sought to influence developments in cancer identities, care and research. We end by suggesting that we extend our understanding of innovations in the fields of cancer research to take better account of these wider social and cultural innovations, together with patients, activists' and sociologists' contributions therein

Faith in Lancelot Andrewes’s preaching

This article analyses the role of faith in Andrewes’s preaching. Andrewes’s position as an avant-garde conformist who paved the way for a Laudian ecclesiology has led to a focus in his scholarly reception on ceremonies and sacraments. Andrewes’s understanding of faith, and its instrumental role in his scriptural hermeneutics, are fields of enquiry which remain neglected. This article demonstrates that he was, in fact, consistently invested in examining what can be known by faith, and how this way of knowing functions. Drawing on Andrewes’s critically overlooked early lectures, which demonstrate the close relationship between faith and knowledge in his thought, it evinces the continuing importance of a faith-based hermeneutic in Andrewes’s later preaching. In his Easter Day sermons, Andrewes explores the limits of a variety of probative methods (forensic, antiquarian) in order to demonstrate the operation of an interpretive faith rooted in exegetical, devotional and liturgical practices