3,141 research outputs found
The effect of movement variability on putting proficiency during the golf putting stroke
Movement variability has been considered important to execute an effective golf swing yet is comparatively unexplored regarding the golf putt. Movement variability could potentially be important considering the small margins of error between a successful and a missed putt. The aim of this study was to assess whether variability of body segment rotations influence putting performance (ball kinematic measures). Eight golfers (handicap range 0–10) performed a 3.2 m level putt wearing retro-reflective markers which were tracked using a three-dimensional motion analysis system sampling at 120 Hz. Ball roll kinematics were recorded using Quintic Ball Roll launch monitor. Movement (segment) variability was calculated based on a scalene ellipsoid volume concept and correlated with the coefficient of variation of ball kinematics. Statistical analysis showed no significant relationships between segment variability and putting proficiency. One significant relationship was identified between left forearm variability and horizontal launch angle, but this did not result in deficits in putting success. Results show that performance variability in the backswing and downswing is not related to putting proficiency or the majority of ball roll measures. Differing strategies may exist where certain golfers may have more fluid movement patterns thereby effectively utilising variability of movement. Therefore, golf instructors should consider movement variability when coaching the golf putt
Reliability of an experimental method to analyse the impact point on a golf ball during putting
This study aimed to examine the reliability of an experimental method identifying the location of the impact point on a golf ball during putting. Forty trials were completed using a mechanical putting robot set to reproduce a putt of 3.2 m, with four different putter-ball combinations. After locating the centre of the dimple pattern (centroid) the following variables were tested; distance of the impact point from the centroid, angle of the impact point from the centroid and distance of the impact point from the centroid derived from the X, Y coordinates. Good to excellent reliability was demonstrated in all impact variables reflected in very strong relative (ICC = 0.98–1.00) and absolute reliability (SEM% = 0.9–4.3%). The highest SEM% observed was 7% for the angle of the impact point from the centroid. In conclusion, the experimental method was shown to be reliable at locating the centroid location of a golf ball, therefore allowing for the identification of the point of impact with the putter head and is suitable for use in subsequent studies
A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines
Novel fluorine-18 labelled luminescent rhenium tricarbonyl complexes were synthesised to test their utility as agents for position emission tomography (PET) and optical hybrid imaging. These experiments lead to the discovery of a rhenium complexation-dissociation method, which produced never-before-seen radiotracers in substantial radiochemical yields that were unable to be radiosynthesised by traditional means. This method was further applied to the successful production of the Alzheimer’s disease PET imaging nuclear medicine, [18F]CABS13, and new analogues thereof
Tiludronate and clodronate do not affect bone structure or remodeling kinetics over a 60 day randomized trial
Background
Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal disorders in horses, data regarding the effect on bone structure and remodeling is lacking. Additionally, due to off-label use of these drugs in young performance horses, effects on bone in young horses need to be investigated. Therefore, the purpose of this randomized, experimental pilot study was to determine the effect of tiludronate and clodronate on normal bone cells, structure and remodeling after 60 days in clinically normal, young horses. Additionally, the effect of clodronate on bone healing 60 days after an induced defect was investigated.
Results
All horses tolerated surgery well, with no post-surgery lameness and all acquired biopsies being adequate for analyses. Overall, tiludronate and clodronate did not significantly alter any bone structure or remodeling parameters, as evaluated by microCT and dynamic histomorphometry. Tiludronate did not extensively impact bone formation or resorption parameters as evaluated by static histomorphometry. Similarly, clodronate did not affect bone formation or resorption after 60 days. Sixty days post-defect, healing was minimally affected by clodronate.
Conclusions
Tiludronate and clodronate do not appear to significantly impact bone tissue on a structural or cellular level using standard dose and administration schedules
Elizabeth Ashley Mitchell in a Sophomore Recital
This is the program for the sophomore voice recital of Elizabeth Ashley Mitchell, accompanied by Cindy Fuller. The recital was held on February 20, 1998, in Mabee Fine Arts Center\u27s McBeth Recital Hall
Environmental isolate developing antibiotic resistance by complementation
Antibiotic resistance is a growing concern within the scientific community. With few new antibiotics being introduced and an increasing number of resistant microbes, routine bacterial infections are becoming more difficult to treat in clinics and hospitals. The purpose of this study is to compare the ability of two environmental isolates – Staphylococcus aureus (S. aureus) and Exiguobacterium undae (E. undae) to grow in solutions of increasing concentrations of tetracycline and ciprofloxacin. After the bacteria showed grow in the solutions, antibiotic susceptibility was tested by examining zones of inhibition on Trypticase Soy Agar (TSA) plates. Our results indicate both isolates were initially susceptible to each antibiotic. The isolates were grown individually and mixed to determine if the isolates could gain resistance to the antibiotics in either environment. Our results demonstrate that E. undae could grow and become resistant in mixed cultures when grown in the presence of S. aureus reflecting the ability of S. aureus to complement microbial growth. Along with the ability of S. aureus to complement the growth of E. undae, it was also able to develop resistance to both ciprofloxacin and tetracycline through repetitive exposure
Effects based warfare: The sum of previous experience
Effects Based Warfare (EBW) describes a novel Western conceptual approach to warfare within which the effects that accrue during war are consistent with, and limited to, those effects envisaged during the planning process. EBW covers action at every level of warfare. It embraces any activity that seeks to influence allies, adversaries, and neutrals, and it demands coherent aftermath planning. Further, it demands inputs from all government departments rather than solely from military sources. EBW is therefore an holistic, pan-governmental construct. The aim of this thesis is to determine whether EBW is an original model of warfare or merely the sum of previous experiences. To resolve this matter the dissertation covers five broad areas: Understanding EBW, which outlines the context for EBW and describes the contemporary Effects Paradigm from first principles; American Origins, which looks at US inputs to the model, combining detailed historical approach with recent doctrinal developments; UK Origins, the UK input to EBW, which analyses a series of groundbreaking governmental papers issued between 1999 and 2004; Operational Case Studies, a set of four discrete historical case studies which from an EBW perspective involve increasing levels of complexity (this adds substance to the conceptual elements of the thesis); and Time for Change? The Early 21st Century which analyses the strategic tapestry of the early Century, delving into matters ranging from the impact of globalisation upon the wider security environment to increasing influence of the media and the re-emergence of humanitarianism. In support of the above aim this thesis seeks to prove three fundamental contentions. First, the extant Western approach to warfare is the product of a previous era - the Cold War and its immediate aftermath - which has failed to develop sufficiently to meet the unique demands of the 21st Century. Hence it is ill-equipped to deliver enduring international security today. Second, an alternative approach began to coalesce shortly after the collapse of the Berlin Wall. This was due initially to the efforts of various US doctrinal theorists, but after their initial mark was made, the baton subsequently picked up by the UK. Indeed within 5 years of this happening, a viable if immature effects paradigm had emerged. Third, whilst the mantra that 'wars have always been conducted for effect' may true, at least at the strategic level, within the context of EBW it is irrelevant; because as this thesis will show, the issue at stake is not whether effects occur per se - which is a given - but the degree to which cause and effect are considered by planners throughout the full depth of warfare
TMIGD1 regulates epithelial cell polarity and morphology
Epithelial cells are unique for their ability to strongly adhere to one another and coordinate communication across an asymmetrical, polar plasma membrane. These properties are necessary for carrying out normal epithelial function, such as absorbing/secreting molecules, repairing wounds, lining organs, etc. Cadherins, claudins, and occludins are major players of epithelial cell adhesion and polarity.
Previously, transmembrane immunoglobulin domain containing-1, TMIGD1, was identified as a novel cell adhesion molecule, whose expression is downregulated in human renal carcinomas. Re-expression of TMIGD1 in renal tumor cells resulted in altered cell morphology and inhibition of tumor growth.
In this study, we examined the hypothesis that TMIGD1 activity is associated with epithelial cell polarity. We demonstrated that TMIGD1 regulates actin stress fibril formation. A 3-dimensional (3D) cell culture assay was developed to examine the role of TMIGD1 in cell morphology and polarity. Our results demonstrate that TMIGD1 regulates actin fibril formation in Madin-Darby Canine Kidney (MDCK) cells, as blocking TMIGD1 activity by blocking antibody inhibited actin fibril formation in 3D cell culture system. Moreover, ectopic expression of TMIGD1 in rectal carcinoma cells, (RKO) , significantly inhibited filopodia formation. Taken together, our data identifies TMIGD1 as a possible regulator of epithelial cell morphology and polarity.2020-07-03T00:00:00
Understanding students’ experiences in a PE, health and well-being context:a self-determination theory perspective
Framed by Self-Determination Theory, this investigation explored student experience as they engaged in their physical education (PE), health and well-being (HWB) curriculum in Scotland for the first time. We aimed to uncover the features of various learning environments that appeared to impact upon student motivation in PE over the period one academic year. We carried out focus group interviews with students from one state secondary school (secondary 1 and 2; ages 12–14) and its feeder primary schools (primary 7; age 11 years) immediately after a selection of PE lessons throughout the year. Furthermore, to provide some additional context for our analysis, the students in each year completed a questionnaire (pre–post) to identify and understand their motivation for PE over time. The results from the interviews indicated that students had a number of positive and negative PE experiences. However, the results from the questionnaire demonstrate that the students’ experiences during the first year of this ‘new’ curriculum had little impact on their motivation for PE. The findings highlight the importance of mixed methods research to provide context-specific account of student experience. This detail may be critical for the development of informed and effective pedagogy that supports student learning, health and well-being
Democratic Enquirer (Portsmouth, Ohio), April 14, 1848
Democratichttps://digitalcommons.shawnee.edu/democratic_enquirer/1000/thumbnail.jp
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