Deep Learning Segmentation of Spiral Arms and Bars

Machine Learning and the Physical Sciences Workshop, NeurIPS 2023. This is an open access conference contribution distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/We present the first deep learning model for segmenting galactic spiral arms and bars. In a blinded assessment by expert astronomers, our predicted spiral arm masks are preferred over both current automated methods (99% of evaluations) and our original volunteer labels (79% of evaluations). Experts rated our spiral arm masks as `mostly good' to `perfect' in 89% of evaluations. Bar lengths trivially derived from our predicted bar masks are in excellent agreement with a dedicated crowdsourcing project. The pixelwise precision of our masks, previously impossible at scale, will underpin new research into how spiral arms and bars evolve.Peer reviewe

Generalizations of the Abstract Boundary singularity theorem

The Abstract Boundary singularity theorem was first proven by Ashley and Scott. It links the existence of incomplete causal geodesics in strongly causal, maximally extended spacetimes to the existence of Abstract Boundary essential singularities, i.e., non-removable singular boundary points. We give two generalizations of this theorem: the first to continuous causal curves and the distinguishing condition, the second to locally Lipschitz curves in manifolds such that no inextendible locally Lipschitz curve is totally imprisoned. To do this we extend generalized affine parameters from $C^1$ curves to locally Lipschitz curves.Comment: 24 page

REBUF: Jam Resistant BBC based Uncoordinated Frequency Division

One of the central tenants of information security is availability. One common form of attack against the availability of information in wireless networks is jamming. Currently, the most common techniques to provide jam-resistant communication, such as frequency-hopping spread spectrum (FHSS), are based on the use of a symmetric shared secret. However, there are theoretical approaches to jam resistance without a pre-shared secret. One theoretical approach using concurrent codes, called the BBC algorithm, was developed at the United States Air Force Academy. We developed and tested the effectiveness of REBUF, a Jam Resistant BBC based Uncoordinated Frequency Division Multiplexing (FDM) system. REBUF is the first known implementation of the BBC algorithm in a simultaneous frequency division multiplexing system. The contributions of this paper include: demonstrating the practical use of a BBC based FDM system, the ability of such a system to jam traditional orthogonal frequency division multiplexing (OFDM) systems, and the resilience of such a system to some common forms of jamming

Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales

Introduction SARS-CoV-2 infection rarely causes hospitalisation in children and young people (CYP), but mild or asymptomatic infections are common. Persistent symptoms following infection have been reported in CYP but subsequent healthcare use is unclear. We aim to describe healthcare use in CYP following community-acquired SARS-CoV-2 infection and identify those at risk of ongoing healthcare needs.Methods and analysis We will use anonymised individual-level, population-scale national data linking demographics, comorbidities, primary and secondary care use and mortality between 1 January 2019 and 1 May 2022. SARS-CoV-2 test data will be linked from 1 January 2020 to 1 May 2022. Analyses will use Trusted Research Environments: OpenSAFELY in England, Secure Anonymised Information Linkage (SAIL) Databank in Wales and Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 in Scotland (EAVE-II). CYP aged ≥4 and <18 years who underwent SARS-CoV-2 reverse transcription PCR (RT-PCR) testing between 1 January 2020 and 1 May 2021 and those untested CYP will be examined.The primary outcome measure is cumulative healthcare cost over 12 months following SARS-CoV-2 testing, stratified into primary or secondary care, and physical or mental healthcare. We will estimate the burden of healthcare use attributable to SARS-CoV-2 infections in the 12 months after testing using a matched cohort study of RT-PCR positive, negative or untested CYP matched on testing date, with adjustment for confounders. We will identify factors associated with higher healthcare needs in the 12 months following SARS-CoV-2 infection using an unmatched cohort of RT-PCR positive CYP. Multivariable logistic regression and machine learning approaches will identify risk factors for high healthcare use and characterise patterns of healthcare use post infection.Ethics and dissemination This study was approved by the South-Central Oxford C Health Research Authority Ethics Committee (13/SC/0149). Findings will be preprinted and published in peer-reviewed journals. Analysis code and code lists will be available through public GitHub repositories and OpenCodelists with meta-data via HDR-UK Innovation Gateway

e-document prototype

I have spent the last 20 years researching and evolving an approach to designing and writing financial research documents which I call Message-based Design (MBD) & Message-based Writing (MBW). This is evidenced in the two A3 research background folders submitted on the theory behind Message-based Design & Writing. The output is a working prototype produced by a venture capitalist firm called 'Wicked Wisdom' based on my research. It is an e-document pioneering the way for research notes from Stockbrokers & Asset Management companies. It 'collapses out' from front to inside with video and sound, produced in flash and now being re-purposed in Java script. We need to radically re-think typography for text-rich business documents & publications (not referring to books). Most designers assume people have time to read. In reality the following occurs: Observations: 1) We browse/forage (71%) then read (11%) 2) People have different time tolerances and requirements for detail i.e. the same information is required to different levels of detailing dependent on the time the reader can allocate to it (Senior directors will have less time than juniors). 3) People want choice as to whether they wish to view information on paper, i-phone, PowerPoint or via web/screen. 4) Most publications do not follow the cognitive principles of how we are Œwired‚ to interpret visual signals. Message-based Design & Message-based Writing (MBD/MBW) is a system that addresses these 4 points and allows key messages to be understood prior to reading simply by scanning the page with its embedded Œvisual hooks‚ to draw the reader in. Thus it overcomes Œfilter failure‚ a phrase coined and first used by Clay Shirky at the Web 2.0 Expo. It collapses to a summary and exploits the way we are wired. Additionally it caters for up to 4 time tolerances of readers and morphs‚ from paper to screen effortlessly

The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials

BACKGROUND: A systematic review, with or without a meta-analysis, should be undertaken to determine if the research question of interest has already been answered before a new trial begins. There has been limited research on how systematic reviews are used within the design of new trials, the aims of this study were to investigate how systematic reviews of earlier trials are used in the planning and design of new randomised trials. METHODS: Documentation from the application process for all randomised trials funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) between 2006 and 2008 were obtained. This included the: commissioning brief (if appropriate), outline application, minutes of the Board meeting in which the outline application was discussed, full application, detailed project description, referee comments, investigator response to referee comments, Board minutes on the full application and the trial protocol. Data were extracted on references to systematic reviews and how any such reviews had been used in the planning and design of the trial. RESULTS: 50 randomised trials were funded by NIHR HTA during this period and documentation was available for 48 of these. The cohort was predominately individually randomised parallel trials aiming to detect superiority between two treatments for a single primary outcome. 37 trials (77.1%) referenced a systematic review within the application and 20 of these (i.e. 41.7% of the total) used information contained in the systematic review in the design or planning of the new trial. The main areas in which systematic reviews were used were in the selection or definition of an outcome to be measured in the trial (7 of 37, 18.9%), the sample size calculation (7, 18.9%), the duration of follow up (8, 21.6%) and the approach to describing adverse events (9, 24.3%). Boards did not comment on the presence/absence or use of systematic reviews in any application. CONCLUSIONS: Systematic reviews were referenced in most funded applications but just over half of these used the review to inform the design. There is an expectation from funders that applicants will use a systematic review to justify the need for a new trial but no expectation regarding further use of a systematic review to aid planning and design of the trial. Guidelines for applicants and funders should be developed to promote the use of systematic reviews in the design and planning of randomised trials, to optimise delivery of new studies informed by the most up-to-date evidence base and to minimise waste in research

Evaluation of Dopamine D3 Receptor Antagonists PG01037, PG01042, and VK4-116 Against D1R-induced Dyskinesia

Parkinson’s Disease (PD) results in motor deficits that can be relieved with L-DOPA, a dopamine (DA) replacement therapy. Unfortunately, chronic treatment often leads to L-DOPA-induced dyskinesia (LID), a debilitating side effect characterized by abnormal involuntary movements (AIMs). Overactivity of the direct striatonigral pathway is seen in LID and is characterized by potent changes in D1 and D3 receptors (D1R, D3R). Further, D1R and D3R may physically and functionally interact to form D1R-D3R heteromer thereby potentiating LID. This D1R-D3R heteromer uniquely switches from G-protein dependent to G-protein independent signaling, allowing for an avenue to manage LID. To uncover the role of these pathways in LID, Sprague-Dawley rats were rendered hemi-parkinsonian and treated daily for 2 weeks with L-DOPA (6 mg/kg; s.c.) to induce stable LID. In a within subjects, counterbalanced design, they were then split into treatment groups that received D3R antagonists: PG01037 (10, 30 mg/kg; i.p.), PG01042 (5, 10 mg/kg; i.p.), or VK4-116 (10, 20 mg/kg; i.p.). PG01037 (PG1) is a mixed D3R antagonist, acting at both the G-protein dependent and independent pathways. PG01042 (PG2) acts as an antagonist on G-protein independent signaling and VK4-116 acts as a G-protein dependent antagonist. All drugs were tested against D1R agonist-induced dyskinesia with SKF38393 (2mg/kg; s.c.). The only effects found were with PG2 which implicates promotion of the D1R G-protein dependent pathway as contributing to D1R-induced dyskinesia. Future studies with these drugs and L-DOPA treatment should unveil the importance of D1R, D3R, and D1R-D3R influences in the presence of the natural ligand DA.https://orb.binghamton.edu/research_days_posters_2021/1038/thumbnail.jp