PEMBERDAYAAN KELOMPOK IBU YANG MEMILIKI BALITA BERISIKO STUNTING DI BANJAR TRIWANGSA-PAYANGAN GIANYAR BALI

Stunting is still a major nutritional problem in Indonesia and Bali. One district that has a fairly high stunting rate is Bresela Village, Payangan District. Triwangsa is one of the district located in Bresela village, based on a quick survey conducted on pregnant women and mothers who have babies under two years old in Triwangsa district, Bresela Village, Payangan, low knowledge and bad attitudes and behavior towards stunting prevention especially in terms of time, type and form of complementary feeding as a nutritional intake for the first 1000 days of life. The service implementation method is in the form of interactive dialogue and a demonstration of making balanced solid food. This activity succeeded in increasing partners' knowledge by 75% regarding stunting and balanced complementary foods of breast milk. After the assistance is carried out, it can be seen that the behavior changes of partners in providing balanced complementary foods to toddlers

Association of ELMO1 Genetic Polymorphism (rs741301) with the Progression of Diabetic Kidney Disease in Balinese Patients with Type 2 Diabetes Mellitus

Background: Diabetic kidney disease (DKD) is one of diabetes mellitus microvascular complications. Engulfment and cell motility 1 (ELMO1) protein interacts with dedicator of cytokinesis 180 (DOCK180) and cyclooxygenase (COX)-2, which affects gene expression in extracellular matrix (ECM) and causes glomerular damage in several mechanisms, such as ECM accumulation and renal tubules thickening. Single nucleotide polymorphism (SNP) rs741301 is one of the ELMO1 genetic polymorphisms involved in DKD. The aim of this study was to evaluate the association between ELMO1 rs741301 polymorphism and DKD in type 2 diabetes mellitus (T2DM) among Balinese.Materials and methods: This study was an observational analytical study with case-control method. Subjects were divided into control and case groups comprising 40 subjects each. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of DNA from T2DM patients were performed to detect the polymorphism in ELMO1 rs741301. Genotype and allele distribution obtained from this study was analyzed by chi-square (χ2) test and Hardy-Weinberg equilibrium law (p<0.05; CI: 95%).Results: There was no significant difference between genotype or allele distribution of ELMO1 rs741301 with DKD incidence. Genotype AA against GG had odds ratio (OR) of 0.793 (p=0.814), AG against GG had OR of 0.602 (p=0.674), and A allele against G allele had OR of 0.761 (p=0.509).Conclusion: There is no significant relationship between ELMO1 rs741301 polymorphism and DKD in T2DM patients among Balinese.Keywords: ELMO1 gene, diabetic kidney disease, polymorphis