Part 3. A Novel Stereocontrolled, In Situ, Solution- and Solid-Phase, Aza Michael Approach for High-Throughput Generation of Tetrahydroaminoquinoline-Derived Natural-Product-like Architectures

With the goal of rapidly accessing tetrahydroquinoline-based natural-product-like polycyclic architectures, herein, we report an unprecedented, in situ, stereocontrolled Aza Michael approach in solution and on the solid phase. The mild reaction conditions required to reach the desired target are highly attractive for the use of this method in library generation. To our knowledge, this approach has not been used before, and it opens a novel route leading to a wide variety of tetrahydroquinoline-derived bridged tricyclic derivatives.NRC publication: Ye

Comparative Compositional Analysis and Pesticidal Efficacy of Essential Oils from Leaves of Skimmia Aanquetilia N.P. Taylor and Airy Shaw

The objective of the current study was to re-examine the chemical components of the essential oil (EO) from the aerial parts of Skimmia anquetilia N.P. Taylor & Airy Shaw in two different seasons designated as Skimmia anquetilia rainy season essential oil (SKREO) and Skimmia anquetilia winter season essential oil (SKWEO). The GC-MS analysis of SKREO and SKWEO resulted in the identification of 42 and 48 constituents, comprising of 95.3 % and 95.4 % of the total composition respectively. Both SKREO and SKWEO varied in their chemical composition in terms of quantity viz: linalyl acetate (15.8% - 17.6%), linalool (13.2% - 13.9%), geijerene (11.6% - 11.7%), α-thujene (11.3% - 11.1%), α-terpineol (6.1% - 6.1%), geranyl acetate (5.0% - 5.1%), α-terpinyl acetate (3.3% - 3.1%), myrcene (3.0% - 3.1%), geraniol (2.6% - 1.9%), α-pinene (2.1% - 2.2%), trans-β-ocimene (2.1% - 2.3%), cis-β-ocimene (2.0% - 2.2%) and neryl acetate (2.3% - 2.4%). Besides qualitative differences SKREO and SKWEO, both were studied for their pesticidal activities. The study exhibited potent antifeedant activity against Spodoptera litura and nematicidal activity against Meloidogyne incognita. Based on the present observations, it was found that besides its academic importance, shrub Skimmia anquetilia can be a good source of phytochemicals like linalyl acetate, linalool, geijerene, thujene and can be used for the development of herbal source for antifeedant and nematicidal activity after proper clinical trials

Recent changes to adult national immunization programs for pneumococcal vaccination in Europe and how they impact coverage: A systematic review of published and grey literature

ABSTRACTDespite widespread use of pneumococcal vaccines throughout Europe, the burden of pneumococcal disease (PD) in adults is considerable. To mitigate this burden, National Immunization Technical Advisory Groups (NITAGs) and Health Technology Assessment (HTA) agencies assess the value of different vaccine schedules for protecting against PD. The aim of this review was to assess the evidence and rationales used by NITAGs/HTA agencies, when considering recent changes to National Immunization Programs (NIPs) for adults, and how identified changes affected vaccine coverage rates (VCRs). A systematic review was conducted of published literature from PubMed® and Embase®, and gray literature from HTA/NITAG websites from the last 5 y, covering 31 European countries. Evidence related to NIP recommendations, epidemiology (invasive PD, pneumonia), health economic assessments and VCRs were collected and synthesized. Eighty-four records providing data for 26 countries were identified. Of these, eight described explicit changes to NIPs for adults in seven countries. Despite data gaps, some trends were observed; first, there appears to be a convergence of NIP recommendations in many countries toward sequential vaccination, with a pneumococcal conjugate vaccine (PCV), followed by pneumococcal polysaccharide vaccine 23. Second, reducing economic or healthcare burden were common rationales for implementing changes. Third, most health economic analyses assessing higher-valency PCVs for adults found its inclusion in NIPs cost-effective. Finally, higher coverage rates were seen in most cases where countries had expanded their NIPs to cover at-risk populations. The findings can encourage agencies to improve surveillance systems and work to reach the NIP’s target populations more effectively