EVALUATION OF TOTAL PHENOLIC, FLAVONOIDAL CONTENT, AND DPPH FREE RADICAL SCAVENGING ACTIVITY OF METHANOLIC EXTRACT OF AILANTHUS EXCELSA ROXB.

Objective: Estimation of total phenol, flavonoid and antioxidant activity of various plant parts (leaves, stem, root, flower and fruit) of Ailanthus excelsa Roxb. methanolic extracts.Methods: Different plant parts were extracted with methanol, then the total phenol content was calculated by using Folin–Ciocalteu reagent, total flavonoid content was estimated by using Aluminum Chloride Colorimetric Method and the antioxidant activity was measured by DPPH (1,1-diphenyl-2-picrylhydrazyl radical) assay.Results: The highest total phenolic content (48.38 mg GAE/gdw) was observed in flower and lowest phenolic content in root (28.56 mg GAE/gdw). The highest total flavonoidal content (21.5 mg QE/gdw) was found in leaf and lowest in root (1.11 mg QE/gdw). The highest radical scavenging activity was found in flower extracts with the IC50 value of 36.85 µg/ml and the lowest scavenging activity was observed in root extract that was found to be 1493.46µg/ml.Conclusion: According to the results of present investigation the plant showed significant antioxidant activity that can be used for medical purpose for the treatment of various diseases.Keywords: Antioxidant activity, Ailanthus excelsa Roxb., Total phenolic content, Total flavonoid content, DPPH (2, 2- diphenyl- 1- picryl hydrazyl), Scavenging activity.                                                              Â

The Samagra anti-poverty programme in Madhya Pradesh: integrating household data, overcoming silo-problems and leaving nobody behind.

AbstractIf it is ‘to leave nobody behind’ in pursuit of the Sustainable Development Goals (SDGs), then a state requires a comprehensive and continuously updated database of individuals and households within its jurisdiction. Consolidation of this data can also assist in overcoming silo-based fragmentation in state delivery of anti-poverty programmes and services. We explore the feasibility of establishing such a database through an extended case study of Samagra (meaning ‘all comprehensive’) in the Indian state of Madhya Pradesh. Samagra was developed to facilitate integrated monitoring and management of all major government-to-people (G2P) cash transfers in the state, and (more radically) to support a paradigm shift from a demand-led to an entitlement-based approach to benefit delivery. Samagra is a unified population monitoring system based on continuous recording of household level demographic events, linked both to operational records of participation in diverse G2P programmes and to financial accounts provided by designated financial institutions operating within a five-kilometre radius of each household. The paper offers a practitioner’s account of Samagra’s introduction, including implementation challenges, policy outcomes and issues meriting further research and discussion.<br/

Our experience on non-descent vaginal hysterectomy: a forgotten skill

Background: Hysterectomy is the most commonly performed major gynecological procedure. It can be done by different routes like abdominal or vaginal or laparoscopic route. Vaginal route of hysterectomy is undoubtedly less popular these days due to inclination towards laparoscopic route by both surgeon as well as patients. Keeping this is mind we have planned this paper to share our experience of Non Descent Vaginal Hysterectomy at a tertiary level hospital. Methods: A retrospective study was conducted at the department of obstetrics and gynecology of Vardhmann Mahavir Medical College &amp; Safdarjung hospital, New Delhi over the period of one year. All the patients undergoing non -descent vaginal hysterectomy for benign indication with adequate vaginal access, without suspected adnexal pathology, who did not have any uterine descent were included in the study. In bigger size uterus morcellation techniques like bisection, debulking, myomectomy, slicing was used to remove the uterus. Intraoperative findings and post-operative complications were recorded. Statistical analysis was done. Results: During the study period total 138 hysterectomies were performed. Most of the women were in the age group of 46 to 50 years (50%). All patients were parous. In 56% patients, uterine size was 8-10 weeks. Fibroid uterus (37%) followed by adenomyosis (27%) was the commonest indication for hysterectomy. The most common complication was febrile morbidity (n=13) followed by urinary tract infection (n=9). Conclusions: Non descent vaginal hysterectomy procedure in hand of a skilled surgeon can be done upto 14 weeks uterine size

The unusual presentation of sertoli-leydig cell tumor: a case report

Sertoli cell tumor is very rare variety of ovarian Sertoli‐Leydig cell tumors. Due to nonspecific clinical and imaging features, diagnosis is often made after histopathological examination. Sertoli cell tumors usually presents with the features of virilization. The prognosis is excellent as most are detected in the early stages and surgical resection is often curative in most cases. Here we present a case of Sertoli Cell tumor, where no feature of virilization was present.

Selection of amine combination for CO2 capture in a packed bed scrubber

This investigation was to test different blends of tertiary amine; triethanolamine (TEA) into primary amine; Monoethanolamine (MEA) used to capture CO2 in packed bed scrubber with recycle stream. Four different operating parameters: Amine Combination (A), Dilution Water (B), Liquid Flow rate (C), and Gas Flow rate (D) were varied to study the behavior of the system. Moreover, Taguchi method was employed to establish the order of importance of different parameters in the process. A 4 factor and 3 level was chosen for the study and it was explored using L9 (34 ) orthogonal array design. According to 3-level design 0%, 20% and 30% were chosen for A, 10%, 20% and 30% for B, 1 Lmin−1, 1.5 Lmin−1 and 2 Lmin−1 for C, 8 Lmin−1, 16 Lmin−1 and 20 Lmin−1 for D. To understand the effectiveness order of different operating parameters, three factors namely Absorption efficiency (E), Absorption Rate (RA), and Scrubbing Factor (E) were calculated upon which the order was compared. The highest efficiency of 92.2% was achieved with 20% TEA. However, with 30% of TEA and 20% solvent mix maximum scrubbing factor (E) of 0.63 mol-CO2/mol-Solvent was achieved. As per Taguchi analysis the significance sequence for absorption efficiency (ϕ) was B > C > D > A; for absorption rate C > B > D > A and for scrubbing factor it was C > B > D > A. The blending of tertiary amine seemed advantageous for carbon dioxide capture process

Clinical significance of ultrasonic placental grading during third trimester in hypertensive disorders in pregnancy and its correlation with fetal outcome in tertiary care centre

Background: Hypertension is one of the common complications in pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. The aim of the present study was to study placental grading by grading by ultrasonography in pregnancy complicated with hypertension and normotensive gravidas. To compare the foetal outcome regarding placental grading and its correlation pattern of placental grade distribution, type of delivery, foetal distress, birth asphyxia, foetal maturity, perinatal morbidity and mortality.Methods: The present study was conducted for a period of 12 months, which included 200 patients who attended OPD at PDRMC, Udaipur. Inclusion criteria was hypertensive pregnant women with BP >140/90 mmHg. Exclusion criteria was Pregnancy associated with other medical disorders, twin gestation, renal and cardiovascular disease and diabetes mellitus.Results: 100 pregnant women with preeclampsia as study group. The most common age group in study group is 22-23 Years. The grade III placenta was found early third trimester in study group. Caesarean delivery was more common mode of delivery in grade III placenta. In foetal outcome small for gestational age was more among the grade III placenta. Foetal distress, birth asphyxia, perinatal mortality, morbidity more among the grade III placenta among the study group.Conclusions: Foetal complications were significantly more in study group compared to control group. Ultrasound placental grade III was statistically significant in correlating with foetal complications like foetal distress, birth asphyxia, perinatal morbidity and mortality.

Rare cause of stillbirth: a true knot and loop of cord: case report

True knot is an extremely rare condition of the umbilical cord. It affects around 0.3-1.3% of all the pregnancies. It can be loose without obstructing the blood flow to the foetus or can be tight enough to exsanguinate the foetus by compromising the blood flow towards the foetus. A 26 years old, gravida 2, para 1, live 1, with previous 1 caesarean section with hypothyroidism came at 40 weeks POG in labour. No complaints. Antenatal history was uneventful. On examination, patient was stable. Patient was explained risk and demits of TOLAC verses ERCD and opted for TOLAC. Delivered a limp baby. There was presence of one tight loop of cord around neck and one tight true knot over the umbilical cord leading to stillbirth. The umbilical cord is the only blood supply to the foetus during the antepartum and intrapartum period. If the true knot is loose, it will not lead to foetal compromise since foetal circulation is maintained. However, at the time of fetal descent through the birth canal, the knot could be tightened. The tightening knot can occlude fetal circulation resulting in an intrauterine demise. The process of delivery should be very careful and if any fetal distress or non-reactive CTG is present, then an emergency caesarean section must be done. Routine continuous cardiotocography can be the best modality to pick distress at the earliest and to achieve a good outcome of the neonate. A good ultrasonologist can detect nuchal cord and true knot during the antenatal scan.

An unusual presentation of vulvar cavernous hemangioma in a 10-year-old premenarchal girl: a rare entity

Vascular tumors of the female genitalia are unusual. Hemangiomas are benign tumors of the blood vessels. Usually they are asymptomatic but may present as discomfort, pain and other symptoms. However, vulvar cavernous hemangioma can be seen in newborns and infants, but rarely occur in children and adult women. A 10-year old premenarchal girl presented with a painless swelling on her right labia majora since birth which was increasing gradually. On examination, a well-defined, soft, mobile and non-tender multicystic swelling was observed involving right labia majora and minora of approximately 5×6 cm in size. An ultrasound of the lesion showed a well-circumscribed, hypo echoic mass with multicystic lesion of size 40×14×44 mm arising from right labia majora with vascularity on color Doppler and venous flow on spectral pattern, suggestive of vascular malformation. Surgical excision of lesion was performed with the utmost care to preserve the surrounding healthy tissue and vulvar anatomy. Histopathological examination (HPE) report confirmed the diagnosis of a cavernous hemangioma with no evidence of malignancy. Vulvar cavernous hemangioma is an uncommon vascular tumor that can be rarely seen in pediatric patients. Imaging studies, such as ultrasound and magnetic resonance imaging (MRI), play a crucial role in confirming the diagnosis and guiding the management. Surgical excision with preservation of healthy tissue is the treatment of choice. Long-term follow-up is essential to monitor recurrence and patient's well-being

Synthesis and Characterisation of Some New Aluminium Derivatives of Schiff Bases Containing N, O and S Donor Atoms and the Anti Fertility Activity of the Derivative Al[SC6H4N:C(CH3)CH2COCH3]3

Some new compounds of aluminium having the general formula AI[SC6H4N:C(R) CH2 C(O)R’]3 where R = CH3, R' = CH3 (1); R' = CH3, R' = C6H5 (2); R = CF3, R’ = -C = CH - CH = CHS (3); R = CF3, R’ = C6H5 (4) have been synthesised by the reactions of Al(OPri)3 and the corresponding ligands in 1:3 molar ratios in benzene. Elemental and spectroscopic (IR, 1H, 13C, and 27AI NMR) characterisation of these monomeric compounds reveals monofunctional bidentate behaviour of ligand moiety and the octahedral geometry around aluminium atom. Compound (1), AI[SC6H4N:C(CH3)CH2COCH3], has been tested for its antifertility activity in male albino rats. The oral administration of this compound at the dose level 6.5 rag/rat/day reduced the weights of testes and epididymides. Significant decrease in sperm motility as well as sperm density resulted in the reduction of male fertility by 100%. Production of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and step-19 spermatids declined by 56.10%, 44.42 %, 63.35 % and 64.57 % respectively. These results indicate that the administration of compound (1) in male rats brought about an interference with spermatogenesis which ultimately caused infertility

Comparison of low dose Dhaka regimen of magnesium sulphate with standard pritchard regimen in eclampsia

Background: The purpose of this study was to determine the effects of altitude on severe preeclampsia and eclampsia and subsequent perinatal outcome.Methods: This prospective study was carried out during 1st March 2011 to 29th February 2012 in Department of Obstetrics and Gynaecology, Kamla Nehru State Hospital for Mother and Child, Indira Gandhi Medical College, Shimla situated at a height of 2200m from sea level. All the subjects with severe preeclampsia or eclampsia were included in the study and their perinatal outcome was noted.Results: There were a total of 5897 deliveries. There were 423 cases of PIH making an incidence of severe preeclampsia and eclampsia 15.4% and 7.3% among PIH, respectively. Majority of cases (60.4%) belonged to age group 18-25 year with mean systolic blood pressure in eclampsia was 184.3±18.6 mm of Hg and in severe preeclampsia was 171.5±13.9 mm of Hg. Mean diastolic blood pressure was 125.8±12.6 mm of Hg in eclampsia and 118.6±4.3 mm of Hg in severe preeclampsia. Various other complications in eclampsia and severe preeclampsia cases included IUGR (35.1%) cases, abruptio placentae (15.9%), HELLP syndrome (9.6%) cases, spontaneous preterm labour (21.3%) and intrauterine death (6.4%). Live births were 85.1%; fresh still births were 8.5%. Mean birth weight was 2192.5±572grams. Respiratory distress syndrome was seen in 21.3% neonates, Hyperbilirubinemia was seen in 26.2% neonates intracranial bleeding was seen in 7.5% neonates. Perinatal mortality was 27.7% which constitute14.9% still birth neonatal deaths.Conclusions: Efficacy of MgSO4 in prevention and treatment of eclamptic convulsions is time tested and supported with a variety of studies. Since its narrow therapeutic and toxicity is major concern, the use of low dose MgSO4 protocols is a viable alternative to standard dose therapy. However, because of small study design further studies on the larger scale are required to support routine clinical use of low dose protocols