7 research outputs found
Hypophosphataemia after intravenous iron therapy with ferric carboxymaltoseâReal world experience from a tertiary centre in the UK
Background:
Iron deficiency is the most common global cause of anaemia. Intravenous (IV) iron is used to correct iron deficiency anaemia (IDA) where oral iron cannot be used. Despite being effective, certain IV iron formulations cause significant hypophosphataemia. However, current knowledge on the clinical consequences of IV ironâinduced hypophosphataemia is broadly anecdotal or limited to isolated case reports.
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Aims:
To retrospectively examine the incidence and potential clinical consequences of hypophosphataemia postâIV ferric carboxymaltose (FCM) in hospitalised patients with IDA (mixed aetiology). /
Methods:
Data were collected for 162 patients, who received a total of 169 FCM courses during a 2âyear audit period. Outcomes included incidence of moderate/severe hypophosphataemia (serum phosphate <0.65 mmol/L) â€90 days postâFCM, changes in alkaline phosphatase, need for phosphate replacement, and length of hospital stay. /
Results:
The incidence of moderate/severe hypophosphataemia postâFCM was 33.7%; within this group the rate of severe hypophosphataemia (serum phosphate â€0.32 mmol/L) was 8.8%. Moderate/severe hypophosphataemia persisted, with 35% of patients having a serum phosphate of <0.65 mmol/L for â€90 days at the last measurement after IV FCM. Intervention with IV phosphateâan average of 4.4 infusions per personâwas required in 29.8% of cases with moderate/severe hypophosphataemia. FCMâinduced moderate/severe hypophosphataemia was associated with a significantly longer hospital stay (P < 0.0035). /
Conclusions:
Moderate/severe hypophosphataemia is a frequent adverse drug reaction with FCM. In our study, FCMâinduced moderate/severe hypophosphataemia was also persistent, often required treatment, and was associated with longer hospital stay