Impact of Ambulation Status in Patients with End-stage Renal Disease on Hemodialysis due to Diabetic Nephropathy : The PREDICT Study

Article信州医学雑誌 68(3): 131-138(2020)journal articl

for patients with advanced biliary tract cancer

Background: The prognosis of patients with advanced biliary tract cancer (BTC) is extremely poor and only a few standard treatments are available for this condition. We performed a phase I trial to investigate the safety, immune response and anti-tumor effect of vaccination with three peptides derived from cancer-testis antigens. Methods: This study was conducted as a phase I trial. Nine patients with advanced BTC who had unresectable tumors and were refractory to standard chemotherapy were enrolled. Three HLA-A*2402 restricted epitope peptides-cell division cycle associated 1 (CDCA1), cadherin 3 (CDH3) and kinesin family member 20A (KIF20A)-were administered subcutaneously, and the adverse events and immune response were assessed. The clinical effects observed were the tumor response, progression-free survival (PFS) and overall survival (OS). Results: The three-peptide vaccination was well-tolerated up to a dose of 3 mg per peptide (9 mg total). No grade 3 or 4 adverse events were observed after vaccination. Peptide-specific T cell immune responses were observed in all patients and stable disease was observed in 5 of 9 patients. The median PFS and OS were 3.4 and 9.7 months. The Grade 2 injection site reaction and continuous vaccination after PD judgment appeared to be prognostic of OS. Conclusions: Multiple-peptide vaccination was well tolerated and induced peptide-specific T-cell responses

Photoproduction of η-mesons off C and Cu Nuclei for Photon Energies below 1.1 GeV(I. Nuclear Physics)

The η-meson photoproduction cross sections have been measured on C and Cu targets for photon energies between 600 and 1100MeV to investigate the behavior of the S_11 (1535) resonance in a nucleus. The excitation functions of the cross section as well as angular and momentum distributions of η-mesons are in quantitative agreement with Quantum Molecular Dynamics (QMD) model calculations, in which the η-meson emission processes other than the S_11 (1535) resonance are also incorporated as proposed in the η-MAID model. It is shown that the excitation of the D_15 (1675) resonance might play an important role for E_γ>900MeV