Seismic stratigraphy and history of deep circulation and sediment drift development in Baffin Bay and the Labrador Sea

Drilling results and seismic-reflection records at and across Ocean Drilling Program (ODP) Sites 645 (western Baffin Bay), 646, and 647 (Labrador Sea) provide important constraints on the history of deep-water circulation and sedimentation in response to Cenozoic climatic change, as well as the tectonic evolution of the region. Sites 646 and 647 were drilled on the flanks of two sediment drift deposits—the Eirik Ridge and Gloria Drift, respectively. Age control at Site 645 was poor because of the restricted biotas there, but the drill site provides a continuous sequence from the lower Miocene to the present. Sediment at Site 646 was deposited at high rates, providing a high resolution record of the last 8.5 Ma. At Site 647 sedimentation was variable and discontinuous, but a complete upper-lower Eocene through lower Oligocene sequence was recovered, whereas the upper Oligocene to Holocene sequence was interrupted by several hiatuses. The drift sequence at Site 646 was constructed after the middle to early Pliocene (ca. 4.5 Ma). Before that time, evidence exists for variable bottom-current activity, with events at about 7.5 Ma (a change in water-mass characteristics and decreasing velocities) and 5.6 Ma (an increase in current velocity preceding the major 4.5-Ma event; R2 regional reflector). The 7.5-Ma event produced a major regional reflector (R3/R4), which was originally thought to be Eocene/ Oligocene in age. A major water-mass change also occurred at the onset of ice-rafting at about 2.5 Ma in the late Pliocene. In seismic records no evidence exists of drift building before the early Pliocene, but a probable late-middle Miocene erosional event occurred on the south flank of Eirik Ridge and along the West Greenland margin. Sediment supply from the Imarssuak mid-ocean canyon (IMOC) increased concurrently with the advent of drift construction. Gloria Drift also was built largely after the late Miocene. A major increase in sediment supply occurred in the early Pliocene, following a major hiatus (5.6 to 2.5 Ma; equivalent to the youngest possible age for the R2 reflector underlying Gloria Drift), and most seismic records exhibit sediment waves above this horizon. This increased sediment supply is the result of hemipelagic deposition from encroaching deposits of the North Atlantic mid-ocean canyon, as well as to supply of ice-rafted detritus in the late Pliocene. A hiatus encompasses the interval from approximately 17.5 to 8,2 Ma, and the interval between the two major hiatuses is extremely condensed. A deeper reflector (R3) corresponds to a change from calcareous (below) to opal-rich hemipelagic strata in the lower Oligocene, not to a regional unconformity reflecting increased bottom-water activity, as previously thought. However, some evidence exists to support a latest Eocene-earliest Oligocene increase in bottom-current activity on Gloria Drift. In Baffin Bay, there is evidence for bottom-water activity from textural studies of cores and from apparent drift features exhibited in multichannel lines along the western margin. Probable contour-currents have been active since at least the late middle Miocene, with episodes of decreasing intensity that apparently occurred in the late Miocene and Quaternary. The record from Site 645 and in seismic lines may indicate that formation of bottom water occurred in the late Neogene in Baffin Bay in conjunction with climatic deterioration, but Baffin Bay was not an important source of deep-water masses to the Labrador Sea after the late Pliocene. Not surprisingly, many of the Labrador Sea deep-circulation events correspond closely to major North Atlantic events and to important global climatic and paleoceanographic events, but a major drift-building episode may have occurred later in the Labrador Sea than it did in either the eastern North Atlantic or the western North Atlantic

An Analysis of Indirect Mortality Estimation

This paper investigates the robustness of the Brass child-survivorship indirect mortality estimation technique. It develops an analytical method for studying the error or bias caused in indirect mortality estimates by poor data, badly chosen model functions, and specific demographic assumptions that are often violated in practice. The resulting analytical expressions give insight into the rationale of indirect methods, the conditions under which they are robust, and the magnitude of errors that occur when specific assumptions are violated

Effect of Preheating on the Permeability of Neonatal Rat Stratum Corneum to Alkanols

We heated flat sheets of neonatal rat stratum corneum for various times at temperatures between 40 and 90°C before determining the permeability coefficient (Kp) of propanol and/or hexanol from water. Below 70°C, Kp remained constant; at 75°C, Kp increased linearly with exposure time; at 80°C and above, there was a large increase in under 2 h, with no further increase on longer heating. There was a 15-fold increase in 6-h Kp between 70°C and 80°C, values being constant above 80°C but at a figure less than for lipid-extracted stratum corneum. Thermal analysis showed that the increase in Kp corresponds to changes in the 80°C lipid endotherm, suggesting that the increased Kp is due to a disordering of the lipid structures. The effect of treating preheated stratum corneum with dimethylsulfoxide (DMSO) vapor for 16h was also studied. Below 70°C, Kp was increased five-fold, but between 70 and 80°C this difference was eliminated, so that above 80°C the Kp was the same as with heat treatment alone. We concluded that both heat and DMSO affect the lipid structures of stratum corneum. DMSO produced a small, reversible structural change, while the effect of heat is irreversible and produces a greater degree of disorder in the lipid structures, but the lipid still contributed to the barrier effect of stratum corneum

An Analysis of Indirect Mortality Estimation

For some years, IIASA has placed considerable emphasis on both population studies and methods of analysis and estimation. These two strands of research are combined in this report, which develops an analytical method for the derivation of errors in estimations based on indirect data, and illustrates this method by applying it to Brass's child survivorship estimation technique. The method described here makes it possible to study the sensitivities of estimates to the underlying assumptions, and provides algebraic expressions that are both more general and easier to interpret than computer results. These expressions give some insight into the rationale of the indirect methods, the conditions under which they are appropriate, and the possibilities of correcting the effects of inappropriate assumptions

Flux Stabilization in 6 Dimensions: D-terms and Loop Corrections

We analyse D-terms induced by gauge theory fluxes in the context of 6-dimensional supergravity models. On the one hand, this is arguably the simplest concrete setting in which the controversial idea of `D-term uplifts' can be investigated. On the other hand, it is a very plausible intermediate step on the way from a 10d string theory model to 4d phenomenology. Our specific results include the flux-induced one-loop correction to the scalar potential coming from charged hypermultiplets. Furthermore, we comment on the interplay of gauge theory fluxes and gaugino condensation in the present context, demonstrate explicitly how the D-term arises from the gauging of one of the compactification moduli, and briefly discuss further ingredients that may be required for the construction of a phenomenologically viable model. In particular, we show how the 6d dilaton and volume moduli can be simultaneously stabilized, in the spirit of KKLT, by the combination of an R symmetry twist, a gaugino condensate, and a flux-induced D-term.Comment: 24 pages, 1 figure v2:minor correction

Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII

Five unrelated subjects with dysfunctional coagulation factor VII (FVII) were studied In order to Identify missense mutations affecting function. Exons 2 to 8 and the Intron-exon Junctions of their FVIl genes were amplified from peripheral white blood cell DNA by PCR and screened by SSCP analysis. DNA fragments showing aberrant mobility were sequenced. The following mutations were Identified: In case 1 (FVII: C <1%, FVIl:Ag 18%) a heterozygous A to G transltion at nucleotlde 8915 In exon 6 results In the amlno acid substitution Lys-137 to Glu near the C-termlnus of the FVlla llght chaln; In case 2 (FVII: C 7%, FVll:Ag 47%) a heterozygous A to G transltion at nucleotide 7834 In exon 5 results in the substitution of Gin-100 by Arg in the second EGF-like domain; In case 3 (FVll:C 20%, FVIl:Ag 76%) a homozygous G to A transition at nucleotide position 6055 in exon 4 was detected resulting in substitution of Arg-79 by Gin in the first EGF-like domain; in case 5 (FVIl:C 10%, FVIl:Ag 52%) a heterozygous C to T transition at nucleotide position 6054 in exon 4 also results in the substitution of Arg79, but in this case it is replaced by Trp; case 4 (FVll:C <1%, FVIl:Ag 100%) was homozygous for a previously reported mutation (G to A) at nucleotide position 10715 in exon 8, substituting Gin for Arg at position 304 in the protease domain. Cases 1,2 and 5 evidently have additional undetected mutation

Anti-inflammatory effects of hepatocyte growth factor: induction of interleukin-1 receptor antagonist

Hepatocyte growth factor (HGF) prevents liver failure in various animal models including endotoxin-induced acute liver failure. We were interested to find out whether human HGF exerts anti-inflammatory effects by modulation of cytokine synthesis. Therefore, human HepG2 cells were cultured with increasing concentrations of HGF. HGF dose-dependently upregulated the production of interleukin-1 receptor antagonist (IL-1Ra). Incubation of HepG2 cells with interleukin-1beta (IL-1beta) caused an increase in IL-1Ra levels, while interleukin-6 (IL-6) had no effect on IL-1Ra synthesis. Co-stimulation of HepG2 cells with HGF + IL-1beta resulted in a synergistic effect on IL-1Ra mRNA and protein expression. Stimulation of freshly isolated mouse hepatocytes from male C57 BL/6 mice with HGF increased IL-1Ra mRNA and protein synthesis dose-dependently. A co-stimulation with HGF and IL-1beta had a synergistic effect on IL-1Ra mRNA expression but only a partially additive effect on IL-1Ra protein synthesis. HGF-induced IL-1Ra production was significantly decreased by the mitogen-activated protein kinase (MAPK) inhibitor PD98059. Accordingly, HGF stimulation specifically increased MAPK-dependent signalling pathway (p42/44). In contrast, in preactivated PBMC mRNA expression and protein synthesis of IL-1Ra, interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) were unaffected after stimulation with HGF. In conclusion, our data suggest that HGF exerts anti-inflammatory effects by modulating the signal transduction cascade leading to increased expression of IL-1Ra, which might explain the protective and regenerative properties of this cytokine in animal models of liver failure

Quality of life in patients with CRB1-associated retinal dystrophies:A longitudinal study

Purpose: To assess the longitudinal vision-related quality of life among patients with CRB1-associated inherited retinal dystrophies. Methods: A longitudinal questionnaire study included 22 patients with pathogenic CRB1 variants. The National Eye Institute Visual Function Questionnaire (39 items, NEI VFQ-39) was applied at baseline, two-year follow-up, and 4-year follow-up. Classical test theory was performed to obtain subdomain scores and in particular ‘near activities’ and ‘total composite’ scores. The Rasch analysis based on previous calibrations of the NEI VFQ-25 was applied to create visual functioning and socio-emotional subscales. Results:In total, 22 patients with pathogenic CRB1 variants were included, with a median age of 25.0 years (IQR: 13–31 years) at baseline and mean follow-up of 4.0 ± 0.3 years. A significant decline at 4 years was observed for ‘near activities’ (51.0 ± 23.8 vs 35.4 ± 14.7, p = 0.004) and ‘total composite’ (63.0 ± 13.1 vs 52.0 ± 12.1, p = 0.001) subdomain scores. For the Rasch-scaled scores, the ‘visual functioning’ scale significantly decreased after 4 years (−0.89 logits; p = 0.012), but not at 4-year follow-up (+0.01 logits; p = 0.975). The ‘socio-emotional’ scale also showed a significant decline after 2 years (−0.78 logits, p = 0.033) and 4 years (−0.83 logits, p = 0.021). Conclusion: In the absence of an intervention, a decline in vision-related quality of life is present in patients with pathogenic CRB1 variants at 4-year follow-up. Patient-reported outcome measures should be included in future clinical trials, as they can be a potential indicator of disease progression and treatment efficacy.</p

Wind-Blown Bubbles around Evolved Stars

Most stars will experience episodes of substantial mass loss at some point in their lives. For very massive stars, mass loss dominates their evolution, although the mass loss rates are not known exactly, particularly once the star has left the main sequence. Direct observations of the stellar winds of massive stars can give information on the current mass-loss rates, while studies of the ring nebulae and HI shells that surround many Wolf-Rayet (WR) and luminous blue variable (LBV) stars provide information on the previous mass-loss history. The evolution of the most massive stars, (M > 25 solar masses), essentially follows the sequence O star to LBV or red supergiant (RSG) to WR star to supernova. For stars of mass less than 25 solar masses there is no final WR stage. During the main sequence and WR stages, the mass loss takes the form of highly supersonic stellar winds, which blow bubbles in the interstellar and circumstellar medium. In this way, the mechanical luminosity of the stellar wind is converted into kinetic energy of the swept-up ambient material, which is important for the dynamics of the interstellar medium. In this review article, analytic and numerical models are used to describe the hydrodynamics and energetics of wind-blown bubbles. A brief review of observations of bubbles is given, and the degree to which theory is supported by observations is discussed.Comment: To be published as a chapter in 'Diffuse Matter from Star Forming Regions to Active Galaxies' - A volume Honouring John Dyson. Eds. T. W. Harquist, J. M. Pittard and S. A. E. G. Falle. 22 pages, 12 figure