82 research outputs found

    Features of deviant behavior of junior schoolchildren with developmental disorders, depending on the prediction level

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    Social problems of modern society, tension of social relations, significant number of social deviation among children and youth determines the need for early prediction and prevention of socialization disorders of the younger generation. A particular risk group includes children wit h disabilities, which socialization takes place under special conditions, so the task of predicting the threats of their social development seems urgent. The aim of the study was to detect the relationship between the features of deviant behavior and the ability to anticipate future events in the junior schoolchildren with speech, hearing, vision, musculoskeletal system disorders. The study involved 274 schoolchildren aged from 8 to 11 years old (148 schoolchildren without developmental disorders, 126 schoolchildren with developmental disorders). The diagnostic study of schoolchildren was conducted by the method of expert evaluations by Achenbach, the "Guess" method by Peresleni and the "Anticipating the situation outcome with the norm violation" method by Ulyanova V.P. It was found that the ability to predict was determined by the level cognitive development of a child, presence/absence of somatic diseases, experience of social interaction. The anticipation of future events by junior schoolchildren with developmental disorders depends on the health and social experience. Prediction depends on the features of attention, ability to focus, as well as social experience and level of external problems in the schoolchildren without developmental disorders. The materials of this article can be useful for the specialists of educational organizations in the work on preventing behavioral disorders; for the specialists of rehabilitation centers that are engaged in correcting the social and cognitive functions of children with developmental disorders

    Morphometric characteristics of Amaranthus caudatus L. In temperate continental climate

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    The new climate conditions of introduced plants are often very different from their original native places of growing. In this case, these conditions can be considered as stressful. Plants under adverse environmental conditions can adapt at the morphological, physiological, and biochemical levels. This paper discusses the morphological traits of Amaranthus caudatus L. cv. Edulis during introduction process in temperate continental climate. The results show that a combination of environmental factors (temperature, soil moisture, day length) affects the growth and development of plants. Amaranth has a wide response norm and adapts well to new conditions. The functional dependency between a lamina's area and a petiole's length is obtained. Β© 2021 Author(s).Ministry of Education and Science of the Russian Federation, Minobrnauka, (FEUZ-2020-0057)This work was supported by Ministry of Science and Higher Education of the Russian Federation as part of the state assignment number Κ‹ FEUZ-2020-0057

    Basket of Growth: New Export Industries in Sverdlovsk Region

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    The authors examine an export basket and reveal the new export goods for Sverdlovsk region, which might be used to transform the productive structure and upgrade export of the region. For each product, in which the region might develop its comparative advantage, the authors develop a measure of efforts, which are supposed to be made to include this good into the export basket, and a measure of the income level for the product. As a result the authors get a cluster of new and the most attractive export goods. Special methodology is used to choose the best cities to allocate the production of the new export goods.Export goods, comparative advantages, industrial cluster, production allocation

    Non-silicate iron in mineral-associated organic matter of agro-chernozems located on different positions on the slope

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    Data on total non-silicate iron (Fed) content in mineral-associated organic matter (MAOM) of agro-chernozems of different localization on the slope are presented. The distribution of total non-silicate iron in soil profile follows that of organic carbon (OC): the maximum values are confined to the surface horizons, and decrease down the profile. It has been revealed that the change in the content of non-silicate iron in the MAOM of the clay fraction in arable horizons of eroded agro-chernozems is a result of erosion processes, including their intensity, which also depends, among other things, on the slope steepness. A lower slope steepness (4Β°) contributes to an increase in the organic carbon loading on iron oxides, resulting in an increased in iron desorption capacity, while a higher slope steepness (6Β°) results in lower iron desorption capacity. The OC/Fed molar ratio is suggested as an additional indicator of the degree of soil erosion. In clay fractions, of both their position in the soil profile and their position on the slope, the predominant mechanism of organic matter stabilization was the formation of organic-iron complexes (OC/Fed > 10). In the Residue fraction of humus horizons, non-silicate iron seems to be presented mainly as iron carbonates (FeCO3), while the proportion of microaggregates (stable under the sonication), where OM is mainly humin, is relatively low against the background of the absolute dominance of primary minerals in this fraction (weight %). Most of the non-silicate iron of mineralassociated OM extracted by dithionite-citrate-hydrocarbonate is localized in the clay fraction – 2/3 or more

    DYNAMICS OF ORGANIC MATTER UNDER THE AFFORESTATION OF THE FORMER AGRICULTURAL SOD-PODZOLIC SOILS

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    The dynamics of the organic matter of the chronosequence of sod-podzolic soils in the process of reforestation has been investigated using the granulo-densitometric fractionation.The objects of research were sod-podzolic soils of the chronosequence of abandoned areas, including the main stages of the development of secondary succession: from overgrowing by grass vegetation to zonal spruce forests of the specially protected natural territory of the Central Forest State Natural Biosphere Reserve. In the first 20–25 years after the reduction of agrocenosis, degradation changes of the humus state of sod-podzolic soils were observed, due to the lack of agrotechnological treatments and the lack of fresh organic matter (OM) of cultivated plants. It is shown that only after 50 years functioning in the reservoir regime, the qualitative and quantitative indicators of organic matter of sod-podzolic soils begin to approach those of spruce forests of different species composition over 100 years old. This is manifested in an increase in the amount of discrete OM, the level of carbon accumulation of this fraction of OM in the soil and the value of its share in the total carbon accumulation in the soil

    Научная ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Β«Π‘ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅, Π±ΠΈΠ±Π»ΠΈΠΎΠ³Ρ€Π°Ρ„ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ ΠΊΠ½ΠΈΠ³ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅Β» ΠΈ ΠΏΡ€ΠΎΡ„ΠΈΠ»ΡŒΠ½Ρ‹Π΅ диссСртационныС исслСдования (1999–2020)

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    In the modern world, global changes are taking place in all spheres of society, including economy, science, education and culture. In this regard, a detailed analysis and comprehension of ongoing processes become relevant to develop a specific strategy. In 2021, the Ministry of Science and Higher Education adopted the Order Β«On the approval of the nomenclature of scientific specialties for which scientific degrees are awarded <….>”; the nomenclature of scientific specialties was published, where specialty 05.25.03 Β«Library Science, Bibliography science and BibliologyΒ» was not reflected (among pedagogical, historical, philological, technical sciences). This document came next to a draft nomenclature of scientific specialties (2020), which was widely discussed by the scientific community. The library community and representatives of university science carried out a number of activities aimed at changing the situation. The authors recreate the picture of forming and growing the profile scientific specialty, including its presentation in the nomenclature of scientific specialties for which scientific degrees are awarded since 1957; analyze statistic materials on post-graduate training of highly qualified scientific personnel and activity to defense dissertations in 1999–2020; generalize and assess the data, consider the problems and vectors of this specialty development to justify the inclusion of the specialty Β«Library Science, Bibliography Science and BibliologyΒ» in the new nomenclature of scientific specialties to continue the training of highly qualified scientific personnel in graduate school, and to carry out specialized research. The article argues that the consequences of the ongoing reforms in science have led to transformations, slowing down the rotation of scientific personnel, extinguishing the activities of dissertation councils and scientific schools in library science, bibliography and bibliology in the regions and complicating the development of library and information science in general.Π’ соврСмСнном ΠΌΠΈΡ€Π΅ происходят Π³Π»ΠΎΠ±Π°Π»ΡŒΠ½Ρ‹Π΅ измСнСния Π²ΠΎ всСх сфСрах общСства, Π² Ρ‚ΠΎΠΌ числС Π² экономикС, Π½Π°ΡƒΠΊΠ΅, ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈ ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π΅. Π’ связи с этим становятся Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ Π΄Π΅Ρ‚Π°Π»ΡŒΠ½Ρ‹ΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΈ осмыслСниС происходящих процСссов с Ρ†Π΅Π»ΡŒΡŽ Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠΉ стратСгии. Π’ 2021 Π³. ΠœΠΈΠ½ΠΈΡΡ‚Π΅Ρ€ΡΡ‚Π²ΠΎΠΌ Π½Π°ΡƒΠΊΠΈ ΠΈ Π²Ρ‹ΡΡˆΠ΅Π³ΠΎ образования Π±Ρ‹Π» принят ΠŸΡ€ΠΈΠΊΠ°Π· «Об ΡƒΡ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½ΠΈΠΈ Π½ΠΎΠΌΠ΅Π½ΠΊΠ»Π°Ρ‚ΡƒΡ€Ρ‹ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚Π΅ΠΉ, ΠΏΠΎ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ ΠΏΡ€ΠΈΡΡƒΠΆΠ΄Π°ΡŽΡ‚ΡΡ ΡƒΡ‡Π΅Π½Ρ‹Π΅ стСпСни <….>Β», ΠΎΠΏΡƒΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π° Π½ΠΎΠΌΠ΅Π½ΠΊΠ»Π°Ρ‚ΡƒΡ€Π° Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚Π΅ΠΉ, Π² ΠΊΠΎΡ‚ΠΎΡ€ΡƒΡŽ ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ 05.25.03 Β«Π‘ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅, Π±ΠΈΠ±Π»ΠΈΠΎΠ³Ρ€Π°Ρ„ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ ΠΊΠ½ΠΈΠ³ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅Β» (отрасли: пСдагогичСскиС, историчСскиС, филологичСскиС, тСхничСскиС Π½Π°ΡƒΠΊΠΈ) Π½Π΅ Π±Ρ‹Π»Π° Π²ΠΊΠ»ΡŽΡ‡Π΅Π½Π°. Авторы Π²ΠΎΡΡΠΎΠ·Π΄Π°ΡŽΡ‚ ΠΊΠ°Ρ€Ρ‚ΠΈΠ½Ρƒ формирования ΠΈ становлСния ΠΏΡ€ΠΎΡ„ΠΈΠ»ΡŒΠ½ΠΎΠΉ Π½Π°ΡƒΡ‡Π½ΠΎΠΉ ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ, прСдставлСния Π΅Π΅ Π² Π½ΠΎΠΌΠ΅Π½ΠΊΠ»Π°Ρ‚ΡƒΡ€Π΅ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚Π΅ΠΉ, ΠΏΠΎ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ осущСствляСтся присуТдСниС ΡƒΡ‡Π΅Π½Ρ‹Ρ… стСпСнСй, начиная с 1957 Π³., ΠΏΠΎΠ΄Ρ€ΠΎΠ±Π½ΠΎ Π°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΡƒΡŽΡ‚ статистичСскиС ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΏΠΎ ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΊΠ΅ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΠΊΠ°Π΄Ρ€ΠΎΠ² Π²Ρ‹ΡΡˆΠ΅ΠΉ ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ Π² аспирантурС, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡŽ Π·Π°Ρ‰ΠΈΡ‚ диссСртаций Π² 1999– 2020 Π³Π³., ΠΎΡΡƒΡ‰Π΅ΡΡ‚Π²Π»ΡΡŽΡ‚ ΠΎΠ±ΠΎΠ±Ρ‰Π΅Π½ΠΈΠ΅ свСдСний, Π΄Π°ΡŽΡ‚ ΠΈΠΌ ΠΎΡ†Π΅Π½ΠΊΡƒ ΠΈ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°ΡŽΡ‚ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹ ΠΈ Π²Π΅ΠΊΡ‚ΠΎΡ€Ρ‹ развития ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ с Ρ†Π΅Π»ΡŒΡŽ обоснования Π²ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΡ ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ Β«Π‘ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅, Π±ΠΈΠ±Π»ΠΈΠΎΠ³Ρ€Π°Ρ„ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ ΠΊΠ½ΠΈΠ³ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅Β» Π² Π½ΠΎΠ²ΡƒΡŽ Π½ΠΎΠΌΠ΅Π½ΠΊΠ»Π°Ρ‚ΡƒΡ€Ρƒ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚Π΅ΠΉ, продолТСния осущСствлСния ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΊΠΈ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΠΊΠ°Π΄Ρ€ΠΎΠ² Π²Ρ‹ΡΡˆΠ΅ΠΉ ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ Π² аспирантурС ΠΈ провСдСния ΠΏΡ€ΠΎΡ„ΠΈΠ»ΡŒΠ½Ρ‹Ρ… исслСдований. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ Π°Ρ€Π³ΡƒΠΌΠ΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ послСдствия ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠΌΡ‹Ρ… Ρ€Π΅Ρ„ΠΎΡ€ΠΌ Π² Π½Π°ΡƒΠΊΠ΅ ΠΏΡ€ΠΈΠ²Π΅Π»ΠΈ ΠΊ трансформациям, замСдлившим Ρ€ΠΎΡ‚Π°Ρ†ΠΈΡŽ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΠΊΠ°Π΄Ρ€ΠΎΠ², ΡƒΠ³Π°ΡΠ°Π½ΠΈΡŽ Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ диссСртационных совСтов ΠΈ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… школ ΠΏΠΎ Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡŽ, Π±ΠΈΠ±Π»ΠΈΠΎΠ³Ρ€Π°Ρ„ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡŽ ΠΈ книговСдСнию Π² Ρ€Π΅Π³ΠΈΠΎΠ½Π°Ρ… ΠΈ ослоТнСнию развития Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅Ρ‡Π½ΠΎ-ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Π½Π°ΡƒΠΊΠΈ Π² Ρ†Π΅Π»ΠΎΠΌ

    Biochemical composition of tomato fruits of various colors

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    Tomato (Lycopersicon esculentum Mill.) is an economically important and widely cultivated vegetable crop that is consumed both fresh and processed. The nutritional value of tomato fruits is related to the content of carotenoids, polyphenols, sugars, organic acids, minerals and vitamins. Currently, there is a growing interest in the qualitative and quantitative increase in the content of health-promoting compounds in tomato fruits. VIR Lycopersicon (Tourn.) Mill. genetic resources collection includes 7678 accessions of one cultivated and nine wild species, which in turn provides ample opportunities for searching for information on the variability of the content of biologically active substances and searching for sources with a high content of them in the gene pool. Our work presents the results of the study of 70 accessions of cultivated and wild tomato on the main biochemical characteristics: the content of dry matter, ascorbic acid, sugars, carotenoids, chlorophylls and anthocyanins. As the basis for the selection of accessions for the study, accessions with various colors of fruits, including new accessions with varying content of anthocyanin, were taken. As a result of this study, the amplitude of variability in the content of dry matter (3.72–8.88 and 9.62–11.33 %), sugars (1.50–5.65 and 2.20–2.70 %), ascorbic acid (12.40–35.56 and 23.62– 28.14 mg/100 g), titratable acidity (0.14–0.46 and 0.33–0.48 %), chlorophylls (0.14–5.11 and 2.95–4.57 mg/100 g), carotenoids (0.97–99.86 and 1.03–10.06 mg/100 g) and anthocyanins (3.00–588.86 and 84.31–152.71 mg/100 g) in the fruits of cultivated and wild tomatoes, respectively, was determined. We have determined correlations between the content of dry matter and monosaccharides (r = 0.40, p ≀ 0.05), total sugars (r = 0.37, p ≀ 0.05) and ascorbic acid (r = 0.32, p ≀ 0.05); the content of ascorbic acid and carotenoids (r = 0.25, p ≀ 0.05). A high dependence of the content of chlorophyll a and b among themselves (r = 0.89, p ≀ 0.05), as well as between the content of chlorophyll b and anthocyanins (r = 0.47, p ≀ 0.05), the content of Ξ²-carotene (r = 0.26, p ≀ 0.05) and the content of monosaccharides (r = –0.29, p ≀ 0.05) has been noted. We have identif ied tomato accessions with a high content of individual chemical substances, as well as with a complex of traits that can be used as sources in breeding for a high content of dry matter, sugars, ascorbic acid, pigments and anthocyanins

    Non-financial motivation practices: Megafon and Nestle

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    The article examines factors which influence the effectiveness of employee motivation, as well as presents the main aspects that need to be taken into account to develop the optimal system of financial and non-financial motivation of employees in international companies. At the same time, a comparative analysis of existing employee motivation practices is provided, using the example of two giant companies: Megafon and Nestle

    Π˜Π·ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… потрСбностСй ΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚Π΅Π»Π΅ΠΉ Ρ†Π΅Π½Ρ‚Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ Π½Π°ΡƒΡ‡Π½ΠΎΠΉ Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠΈ ΠΊΡ€ΡƒΠΏΠ½ΠΎΠ³ΠΎ ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½ΠΎΠ³ΠΎ Π³ΠΎΡ€ΠΎΠ΄Π° для ΠΎΠΏΡ‚ΠΈΠΌΠΈΠ·Π°Ρ†ΠΈΠΈ Π΅Ρ‘ Π΄ΠΎΠΊΡƒΠΌΠ΅Π½Ρ‚Π½ΠΎ-рСсурсной Π±Π°Π·Ρ‹

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    Scientific libraries as an essential part of science, education, sociocultural and industrial complex of a region (big academic or industrial city) are engaged in developing information and communication environment. Therefore, systematic developing of library and information space is vital. Within the framework of the project β€œRegional scientific libraries in the changing science and education environment” (Fundamental Studies Program of the Russian Academy of Sciences, 2022–2026), the State Public Scientific and Technical Library of the Russian Academy of Sciences Siberian Branch has been designing the model to adapt regional libraries to modern communications and new methods of scientific publications dissemination within the context of social transformations and changing paradigm of library acquisition of scientific literature and information resources, the services provided to specialists in science and education and meeting their information needs, modified user preferences, behavior and reading styles, and the concept of libraries interaction in building and using their document resources. The authors focus on the science and education space and library and information infrastructure of Novosibirsk (big science and education center) and Western Siberia (Tomsk, Kemerovo Regions and Altay Kray) and, for comparison purposes, that of Chelyabinsk, the large industrial center in the Urals.The authors characterize in brief Chelyabinsk industrial, science and academic specialization and its library system (based on the monitoring findings), as well as the primary results of the study of library users information needs (survey based); they also examine the compliance of document resources of Chelyabinsk Regional Universal Scientific Library to the user information needs to update the conceptual model of library and information services offered to students and specialists.НаучныС Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠΈ, являясь Π½Π΅ΠΎΡ‚ΡŠΠ΅ΠΌΠ»Π΅ΠΌΠΎΠΉ Ρ‡Π°ΡΡ‚ΡŒΡŽ Π½Π°ΡƒΡ‡Π½ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ, ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π½ΠΎΠ³ΠΎ ΠΈ ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½ΠΎΠ³ΠΎ комплСкса Ρ€Π΅Π³ΠΈΠΎΠ½Π° (ΠΊΡ€ΡƒΠΏΠ½ΠΎΠ³ΠΎ Π½Π°ΡƒΡ‡Π½ΠΎΠ³ΠΎ ΠΈΠ»ΠΈ ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½ΠΎΠ³ΠΎ Ρ†Π΅Π½Ρ‚Ρ€Π°), ΡƒΡ‡Π°ΡΡ‚Π²ΡƒΡŽΡ‚ Π² создании ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎ-ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠΊΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ срСды. ΠŸΡ€ΠΎΠ±Π»Π΅ΠΌΠ° систСмного формирования Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅Ρ‡Π½ΠΎ-ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ пространства ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½ΠΎΠ³ΠΎ Ρ€Π΅Π³ΠΈΠΎΠ½Π° ΠΏΠΎΠΏΡ€Π΅ΠΆΠ½Π΅ΠΌΡƒ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Π°.Π’ Ρ…ΠΎΠ΄Π΅ выполнСния Π½Π°ΡƒΡ‡Π½ΠΎΠ³ΠΎ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π° «Научная Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠ° Ρ€Π΅Π³ΠΈΠΎΠ½Π° Π² условиях ΠΌΠ΅Π½ΡΡŽΡ‰Π΅ΠΉΡΡ Π½Π°ΡƒΡ‡Π½ΠΎ-ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ срСды» (ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ° Ρ„ΡƒΠ½Π΄Π°ΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹Ρ… исслСдований Российской Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΠΈ Π½Π°ΡƒΠΊ, 2022–2026 Π³Π³.) ГосударствСнная публичная Π½Π°ΡƒΡ‡Π½ΠΎ-тСхничСская Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠ° Бибирского отдСлСния Российской Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΠΈ Π½Π°ΡƒΠΊ (Π“ΠŸΠΠ’Π‘ БО РАН) приступила ΠΊ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π°Π΄Π°ΠΏΡ‚Π°Ρ†ΠΈΠΈ Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊ Ρ€Π΅Π³ΠΈΠΎΠ½Π° ΠΊ соврСмСнной систСмС ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠΊΠ°Ρ†ΠΈΠΉ ΠΈ Π½ΠΎΠ²Ρ‹ΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌ распространСния Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΠΏΡƒΠ±Π»ΠΈΠΊΠ°Ρ†ΠΈΠΉ Π² контСкстС трансформаций социума, ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»Π°Π³Π°ΡŽΡ‰Π΅ΠΉ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅: ΠΏΠ°Ρ€Π°Π΄ΠΈΠ³ΠΌΡ‹ Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊ ΠΏΠΎ Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡŽ Ρ„ΠΎΠ½Π΄ΠΎΠ² Π½Π°ΡƒΡ‡Π½ΠΎΠΉ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ ΠΈ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… рСсурсов; систСмы обслуТивания спСциалистов Π½Π°ΡƒΡ‡Π½ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ комплСкса Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅Ρ‡Π½ΠΎ-ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹ΠΌΠΈ рСсурсами с ΡƒΡ‡Ρ‘Ρ‚ΠΎΠΌ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… потрСбностСй, ΠΌΠΎΠ΄ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΉ Ρ‡ΠΈΡ‚Π°Ρ‚Π΅Π»ΡŒΡΠΊΠΈΡ… ΠΏΡ€Π΅Π΄ΠΏΠΎΡ‡Ρ‚Π΅Π½ΠΈΠΉ ΠΈ ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊ ΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚Π΅Π»Π΅ΠΉ Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊ; ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ†ΠΈΠΈ взаимодСйствия Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊ Ρ€Π΅Π³ΠΈΠΎΠ½Π° ΠΏΡ€ΠΈ Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈ использовании ΠΈΡ… Π΄ΠΎΠΊΡƒΠΌΠ΅Π½Ρ‚Π½ΠΎ-рСсурсной Π±Π°Π·Ρ‹. ΠžΠ±ΡŠΠ΅ΠΊΡ‚Ρ‹ исслСдования – Π½Π°ΡƒΡ‡Π½ΠΎ-ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ пространство ΠΈ Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅Ρ‡Π½ΠΎ-информационная инфраструктура Новосибирска (ΠΊΡ€ΡƒΠΏΠ½Π΅ΠΉΡˆΠ΅Π³ΠΎ Π½Π°ΡƒΡ‡Π½ΠΎΠ³ΠΎ ΠΈ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ†Π΅Π½Ρ‚Ρ€Π°), ΡΡƒΠ±ΡŠΠ΅ΠΊΡ‚ΠΎΠ² Π—Π°ΠΏΠ°Π΄Π½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡ€ΠΈ (Вомской, ΠšΠ΅ΠΌΠ΅Ρ€ΠΎΠ²ΡΠΊΠΎΠΉ областСй ΠΈ Алтайского края) ΠΈ для сравнСния – ΠΊΡ€ΡƒΠΏΠ½ΠΎΠ³ΠΎ ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½ΠΎΠ³ΠΎ Ρ†Π΅Π½Ρ‚Ρ€Π° Π£Ρ€Π°Π»Π° – ЧСлябинска.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ Π΄Π°Π½Π° краткая характСристика ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½ΠΎΠΉ, Π½Π°ΡƒΡ‡Π½ΠΎΠΉ, ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ спСциализации ЧСлябинска, систСмы Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊ (Π½Π° основС Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€ΠΈΠ½Π³Π°); прСдставлСны ΠΏΡ€Π΅Π΄Π²Π°Ρ€ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ обслСдования ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… потрСбностСй ΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚Π΅Π»Π΅ΠΉ Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊ (ΠΏΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ анкСтирования), опрСдСлСния уровня соотвСтствия Π΄ΠΎΠΊΡƒΠΌΠ΅Π½Ρ‚Π½ΠΎ-рСсурсной Π±Π°Π·Ρ‹ ЧСлябинской областной ΡƒΠ½ΠΈΠ²Π΅Ρ€ΡΠ°Π»ΡŒΠ½ΠΎΠΉ Π½Π°ΡƒΡ‡Π½ΠΎΠΉ Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅ΠΊΠΈ ΠΈΡ… ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹ΠΌ потрСбностям для провСдСния дальнСйшСй Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΏΠΎ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ΅ ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π±ΠΈΠ±Π»ΠΈΠΎΡ‚Π΅Ρ‡Π½ΠΎ-ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ обслуТивания спСциалистов ΠΈ учащСйся ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ

    Endometrial expression of FOX proteins (FOXA1 and FOXA2) in women of reproductive age with different endometrial thickness: prospective cohort comparative study

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    Aim. To evaluate the expression of FOX proteins (FOXA1 and FOXA2) in the endometrium during the implantation window in women with a history of reproductive dysfunctions with different thickness of the endometrium. Materials and methods. The prospective cohort comparative study was conducted. The main group included patients with "thin" endometrium (7 mm according to ultrasound on preovulatory days; n=52), the comparison group consisted of women with normal endometrial thickness (7 mm according to ultrasound; n=62; women of both groups with reproductive dysfunctions of unknown reason), the control group included 16 healthy fertile women. Aspiration biopsy of the endometrium was performed on the 68 days after ovulation, as well as venipuncture to obtain a sample of peripheral blood to determine the levels of sex steroids (estradiol E2 and progesterone P). A combined histological and immunohistochemical study of endometrial biopsies was performed. Results. All women had ovulatory values of progesterone P16.1 nmol/l (68 days after ovulation) and normoestrogenemia (E2, pmol/l) in the blood. E2/P was similar in all groups (p0, 05). A pronounced expression of FOXA1 was noted in women with thin endometrium significantly more often (p0.05) with various hormone-receptor characteristics of the endometrium (42% n=22 out of 52) compared with healthy participants (0%; n=0). Reduced FOXA2 expression in the uterine mucosa was significantly more often detected on 68 days after ovulation in women with "thin" endometrium (56% n=29 of 52) than in women with normal endometrial thickness, both in women from the comparison group and in healthy women from the control group (p0.05). In a generalized analysis of the expression of FOX proteins in the endometrium on days 68 after ovulation, it was generally found that every second (50%; n=57 out of 114) women with a history of reproductive disorders (with a reduced and normal M-echo value) expression of proteomic markers differed from healthy women. In the case of "thin" endometrium, more than two thirds of patients (71%; n=37 out of 52) showed differences in endometrial expression of FOX proteins compared with women without a burdened reproductive history. Conclusion. In the majority of women (71%) with a thin endometrium and a history of reproductive dysfunctions, the expression of FOX proteins in the endometrium differed from the control group. Overall, endometrial expression of FOX proteins, which is likely to be different from healthy women, in patients with reproductive dysfunctions of unknown origin is a significant predictor of reproductive failure. At the same time, such an isolated indicator as M-echo value 7 mm according to ultrasound data is not an absolute prognostic marker of endometrial receptivity disorders
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