25 research outputs found
Distribution of hepatitis B infection in Brazil: the epidemiological situation at the beginning of the 21 st century
Polymorphisms in DC-SIGN and L-SIGN genes are associated with HIV-1 vertical transmission in a Northeastern Brazilian population.
DC-SIGN and L-SIGN are receptors expressed on specialized macrophages in decidua, (Hofbauer and placental capillary endothelial cells), known to interact with several pathogens, including HIV-1. To disclose the possible involvement of these molecules in the susceptibility to HIV vertical transmission, we analyzed DC-SIGN and L-SIGN gene single nucleotide polymorphisms (SNPs) in 192 HIV-1 positive children and 58 HIV-1 negative children all born to HIV-1 positive mothers, as well as 96 healthy uninfected children not exposed to HIV-1, all from Northeast Brazil. The frequency of three SNPs in the DC-SIGN promoter (-139G>A, -201G>T and -336A>G) were significantly different when comparing HIV positive children with HIV-1 exposed uninfected children, indicating an association with susceptibility to HIV-1 vertical transmission. This genetic association suggests that DC-SIGN molecule may play a role in susceptibility to HIV-1 infection through vertical transmission
Copy number variation of defensin genes and HIV infection in Brazilian children
Evaluation of Copy Number Variations in HIV positive patients. Identification of a new susceptibility gene
Rapid Genetic Screening for major HLA risk haplotypes in patients with type 1 diabetes from North East Brazil
Association between MBL2 polymorphism and T1D: does ethnicity play a role in the susceptibility of this multifactorial disease?
DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children
Association between DEFB1 gene polymorphisms and HIV infectio
Association between HLA-G 3'UTR 14-bp polymorphism and HIV vertical transmission in Brazilian children
HLA-G polymorphisms analysis in HIV childre