Çocukların Büyük Ebeveynleri İle Etkileşimlerine İlişkin Görüşleri

Bu araştırma, büyük ebeveynleri ile birlikte yaşayan çocukların, büyük ebeveynleri ile etkileşimlerine ilişkin görüşlerini incelemek amacıile Ankara’nın Çankaya ilçesine bağlıBeşevler semtinde yaşayan, kolayda örnekleme yöntemi ile seçilen 300 ilköğretim öğrencisi üzerinde yürütülmüştür. Araştırma kapsamına alınan çocukların yarısından fazlasıkız, çoğunluğunun yaşı12 ve üzerindedir. Çocukların yaşgruplarına göre çocuk ve büyük ebeveyn etkileşimine ilişkin görüşleri incelendiğinde küçük yaşgrubundaki çocukların büyük ebeveynlere bakışaçısının daha olumlu, çocukların yaşlarıbüyüdükçe değerlendirmelerinin daha olumsuz olduğu görülmektedir. Kız çocuklarıbüyük ebeveynleri ile etkileşimlerine yönelik erkeklere göre daha olumlu, erkek çocuklar ise kızlara göre daha olumsuz görüşbildirmişlerdir. Çocukların genç büyük ebeveynler ile daha iyi iletişim kurduklarıve büyük ebeveyne yönelik görüşlerinin daha olumlu olduğu; büyük ebeveynin eğitim düzeyi artıkça çocukların olumlu görüşlerinin ve bazıolumsuz görüşlerinin ortalamalarında artışolduğu belirlenmiştir

Investigation of Gasdermin-D and Pannexin-1 in Omental Adipose and Placental Tissues in Obese Pregnant Women

Aim: Gasdermin-D (GSDMD) and pannexin-1 (PANX1), which are proinflammatory proteins, may be involved in the pathogenesis of complications in pregnant women with obesity. We aimed to investigate the expression of GSDMD and PANX1 biochemically in samples of maternal omental and placental tissue obtained from pregnant women with or without obesity, and their correlation with maternal, obstetric, and fetal/neonatal variables. Methods: The prospective observational study included 79 pregnant women who underwent elective cesarean sections with a pregnancy between 37 and 41 weeks from December 2021 to April 2022. They were divided into three study groups according to their body mass index (BMI): normal weight (with a BMI 30) (n=26). Omental and placental GSDMD and PANX1 levels were measured by enzyme-linked immunosorbent assay between the groups. Results: In the homogenate of omental tissue, the median levels of GSDMD and PANX1 protein in the overweight and obese groups were significantly lower than those in the normal weight groups (p=0.0154 and p=0.0184, respectively). In the placental tissue samples, the median levels of GSDMD and PANX1 proteins in the normal weight, overweight, and obese groups were similar. Conclusion: GSDMD and PANX1 expressions were shown for the first time in the omentum and placenta together; which has the potential to be used as a predictive and diagnostic test panel after further studies in obese pregnant women

P491, I Trionfi / Petrarca. Image 078

https://repository.wellesley.edu/p491/1077/thumbnail.jp

Salvage Treatment Experience in Advanced Synovial Sarcoma: a Multicenter Retrospective Analysis of the Anatolian Society of Medical Oncology

Background: We aimed to evaluate prognostic factors and response rates to various treatment approaches to patients with synovial sarcoma in an advanced setting. Materials and Methods: We retrospectively reviewed the medical records of 55 patients (18 pts; 32.7% women) diagnosed with synovial sarcomas. Twenty had metastatic disease at the time of diagnosis while the remainder of the study group consisted of patients who developed metastatic or inoperable locally advanced disease during follow up. Results: The median follow up time was 15 months (range: 1-53). Regarding outcomes for the 55 patients, 3 and 5 year overall survival rates were 26% and 14%, respectively. In univariate analyses among demographic factors female gender was associated with a better outcome (p=0.030). Patients with early progressing disease (<2 years) had a worse prognosis when compared to patient group with late relapse, but this difference did not reach statistical significance (p=0.056). According to multivariate Cox regression analysis patients who had undergone metastasectomy had a significant survival advantage (p=0.044). The overall response rate to different salvage chemotherapy regimens given as second line treatment was around 42.9-53.9% for all regimes. There were no statistically significant differences between chemotherapy regimens given in either second or third line settings in terms of overall survival. Conclusions: We observed no major differences in terms of response rate and survival between different salvage chemotherapy regimens. Although metastatic disease still carries a poor prognosis, metastasectomy was found to be associated with improved surviva

The effect of distant reiki sessions on holistic well-being

This study investigated the effect of distant Reiki sessions on the holistic well-being of people without no acute/chronic diseases. The study was conducted between February 1 and March 31, 2022. The sample consisted of 180 healthy people living in a city in Turkey. Participants attended 20-minute distant Reiki sessions (intervention) for 4 consecutive days. Pretest data were collected using a personal information form, the Holistic Well-Being Scale (HWBS), the Positive and Negative Affect Schedule (PANAS), and the Subjective Vitality Scale (SVS). Posttest data were collected 2 days (posttest I) and 1 week after the intervention (posttest II) using the HWBS, PANAS, and SVS. There was a statistically significant difference between pretest and posttest I and II HWBS subscale scores (P < .05). There was a statistically significant difference between pretest and posttest PANAS and SVS scores (P < .05). Distant Reiki sessions improved participants' holistic well-being. They also helped them develop a positive mood, experience and perceive less sadness, and develop subjective vitality and cognitive awareness