Halo White Dwarfs and the Hot Intergalactic Medium

We present a schematic model for the formation of baryonic galactic halos and hot gas in the Local Group and the intergalactic medium. We follow the dynamics, chemical evolution, heat flow and gas flows of a hierarchy of scales, including: protogalactic clouds, galactic halos, and the Local Group itself. Within this hierarchy, the Galaxy is built via mergers of protogalactic fragments. We find that early bursts of star formation lead to a large population of remnants (mostly white dwarfs), which would reside presently in the halo and contribute to the dark component observed in the microlensing experiments. The hot, metal-rich gas from early starbursts and merging evaporates from the clouds and is eventually incorporated into the intergalactic medium. The model thus suggests that most microlensing objects could be white dwarfs (m \sim 0.5 \msol), which comprise a significant fraction of the halo mass. Furthermore, the Local Group could have a component of metal-rich hot gas similar to, although less than, that observed in larger clusters. We discuss the known constraints on such a scenario and show that all local observations can be satisfied with present data in this model. The best-fit model has a halo that is 40% baryonic, with an upper limit of 77%.Comment: 15 pages, LaTex, uses aas2pp4.sty, 7 postscript figures. Substantially revised and enlarged to a full-length article. Somewhat different quantitative results, but qualitative conclusions unchange

Logics for the Relational Syllogistic

The Aristotelian syllogistic cannot account for the validity of many inferences involving relational facts. In this paper, we investigate the prospects for providing a relational syllogistic. We identify several fragments based on (a) whether negation is permitted on all nouns, including those in the subject of a sentence; and (b) whether the subject noun phrase may contain a relative clause. The logics we present are extensions of the classical syllogistic, and we pay special attention to the question of whether reductio ad absurdum is needed. Thus our main goal is to derive results on the existence (or non-existence) of syllogistic proof systems for relational fragments. We also determine the computational complexity of all our fragments

Searches for neutrinos in the direction of radio-bright blazars with the ANTARES telescope

Active galaxies, especially blazars, are among the most promising extragalactic candidates for high-energy neutrino sources. To date, ANTARES searches included these objects and used GeV–TeV ¿-ray flux to select blazars. Here, a statistically complete blazar sample selected by their bright radio emission is used as the target for searches of origins of neutrinos collected by the ANTARES neutrino telescope over 13 yr of operation. The hypothesis of a neutrino–blazar directional correlation is tested by pair counting and a complementary likelihood-based approach. The resulting posttrial p-value is 3.0% (2.2s in the two-sided convention). Additionally, a time-dependent analysis is performed to search for temporal clustering of neutrino candidates as a means of detecting neutrino flares in blazars. None of the investigated sources alone reaches a significant flare detection level. However, the presence of 18 sources with a pretrial significance above 3s indicates a p = 1.4% (2.5s in the two-sided convention) detection of a time-variable neutrino flux. An a posteriori investigation reveals an intriguing temporal coincidence of neutrino, radio, and ¿-ray flares of the J0242+1101 blazar at a p = 0.5% (2.9s in the two-sided convention) level. Altogether, the results presented here suggest a possible connection of neutrino candidates detected by the ANTARES telescope with radio-bright blazars.The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commission Européenne (FEDER fund and Marie Curie Program), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Région Alsace (contrat CPER), Région Provence-Alpes-Côte d'Azur, Département du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium für Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; grants PID2021-124591NB-C41, -C42, -C43 funded by MCIN/AEI/ 10.13039/501100011033 and, as appropriate, by "ERDF A way of making Europe," by the "European Union" or by the "European Union NextGenerationEU/PRTR," Programa de Planes Complementarios I+D+I (refs. ASFAE/2022/023, ASFAE/2022/014), Programa Prometeo (PROMETEO/2020/019) and GenT (refs. CIDEGENT/2018/034, /2019/043, /2020/049. /2021/23) of the Generalitat Valenciana, EU: MSC program (ref. 101025085), Spain; Ministry of Higher Education, Scientific Research and Innovation, Morocco; and the Arab Fund for Economic and Social Development, Kuwait. We also acknowledge the technical support of Ifremer, AIM, and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities. Y.Y.K. acknowledges support from the M2FINDERS project, which has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (grant agreement No. 101018682). T.H. was supported by the Academy of Finland projects 317383, 320085, 322535, and 345899. S.K. acknowledges support from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No. 771282.Peer ReviewedArticle signat per 164 autors/es: A. Albert, S. Alves, M. André, M. Ardid, S. Ardid, J.-J. Aubert, J. Aublin, B. Baret, S. Basa, Y. Becherini, B. Belhorma, M. Bendahman, F. Benfenati, V. Bertin, S. Biagi, M. Bissinger, J. Boumaaza, M. Bouta, M. C. Bouwhuis, H. Brânzaş, R. Bruijn, J. Brunner, J. Busto, B. Caiff, D. Calvo, S. Campion, A. Capone, L. Caramete, F. Carenini, J. Carr, V. Carretero, S. Celli, L. Cerisy, M. Chabab, R. Cherkaoui El Moursli, T. Chiarusi, M. Circella, J. A. B. Coelho, A. Coleiro, R. Coniglione, P. Coyle, A. Creusot, A. S. M. Cruz, A. F. Díaz, B. De Martino, C. Distefano, I. Di Palma, A. Domi, C. Donzaud, D. Dornic, D. Drouhin, T. Eberl, T. van Eeden, D. van Eijk, S. El Hedri, N. El Khayati, A. Enzenhöfer, P. Fermani, G. Ferrara, F. Filippini, L. Fusco, S. Gagliardini, J. García, C. Gatius Oliver, P. Gay, N. Geißelbrecht, H. Glotin, R. Gozzini, R. Gracia Ruiz, K. Graf, C. Guidi, L. Haegel, S. Hallmann, H. van Haren, A. J. Heijboer, Y. Hello, J. J. Hernández-Rey, J. Hößl, J. Hofestädt, F. Huang, G. Illuminati, C. W. James, B. Jisse-Jung, M. de Jong, P. de Jong, M. Kadler, O. Kalekin, U. Katz, A. Kouchner, Y. A Kovalev, Y. Y Kovalev, I. Kreykenbohm, V. Kulikovskiy, R. Lahmann, M. Lamoureux, A. Lazo, D. Lefèvre, E. Leonora, G. Levi, S. Le Stum, D. Lopez-Coto, S. Loucatos, L. Maderer, J. Manczak, M. Marcelin, A. Margiotta, A. Marinelli, J. A. Martínez-Mora, P. Migliozzi, A. Moussa, R. Muller, S. Navas, E. Nezri, B. Ó Fearraigh, E. Oukacha, A. Păun, G. E. Păvălaş, S. Peña-Martínez, M. Perrin-Terrin, V. Pestel, P. Piattelli, A. Plavin, C. Poirè, V. Popa, T. Pradier, A. Pushkarev, N. Randazzo, D. Real, S. Reck, G. Riccobene, A. Romanov, A. Sánchez-Losa, A. Saina, F. Salesa Greus, D. F. E. Samtleben, M. Sanguineti, P. Sapienza, J. Schnabel, J. Schumann, F. Schüssler, J. Seneca, M. Spurio, Th. Stolarczyk, M. Taiuti, Y. Tayalati, S. J. Tingay, S. Troitsky, B. Vallage, G. Vannoye, V. Van Elewyck, S. Viola, D. Vivolo, J. Wilms, S. Zavatarelli, A. Zegarelli, J. D. Zornoza, and J. Zúñiga, T. Hovatta, S. Kiehlmann, I. Liodakis, V. Pavlidou, and A. C. S ReadheadPostprint (published version

Nanobeacon: a time calibration device for the KM3NeT neutrino telescope

The KM3NeT Collaboration is currently constructing a multi-site high-energy neutrino telescope in the Mediterranean Sea consisting of matrices of pressure-resistant glass spheres, each holding a set of 31 small-area photomultipliers. The main goals of the telescope are the observation of neutrino sources in the Universe and the measurement of the neutrino oscillation parameters with atmospheric neutrinos. Both extraterrestrial and atmospheric neutrinos are detected through the Cherenkov light induced in seawater by charged particles produced in neutrino interactions in the surrounding medium. A relative time synchronization between photomultipliers of the order of 1 ns is needed to guarantee the required angular resolution of the detector. Due to the large detector volumes to be instrumented by KM3NeT, a cost reduction of the different systems is a priority. To this end, the inexpensive Nanobeacon has been designed and developed by the KM3NeT Collaboration to be used for detector time-calibration studies. At present, more than 600 Nanobeacons have been already produced. The characterization of the optical pulse and the wavelength emission profile of the devices are critical for the time calibration. In this paper, the main features of the Nanobeacon design, production and operation, together with the main properties of the light pulse generated are describedPeer ReviewedPostprint (author's final draft

MRI-targeted or standard biopsy for prostate-cancer diagnosis

Background Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography-guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence is limited. Methods In a multicenter, randomized, noninferiority trial, we assigned men with a clinical suspicion of prostate cancer who had not undergone biopsy previously to undergo MRI, with or without targeted biopsy, or standard transrectal ultrasonography-guided biopsy. Men in the MRI-targeted biopsy group underwent a targeted biopsy (without standard biopsy cores) if the MRI was suggestive of prostate cancer; men whose MRI results were not suggestive of prostate cancer were not offered biopsy. Standard biopsy was a 10-to-12-core, transrectal ultrasonography-guided biopsy. The primary outcome was the proportion of men who received a diagnosis of clinically significant cancer. Secondary outcomes included the proportion of men who received a diagnosis of clinically insignificant cancer. Results A total of 500 men underwent randomization. In the MRI-targeted biopsy group, 71 of 252 men (28%) had MRI results that were not suggestive of prostate cancer, so they did not undergo biopsy. Clinically significant cancer was detected in 95 men (38%) in the MRI-targeted biopsy group, as compared with 64 of 248 (26%) in the standard-biopsy group (adjusted difference, 12 percentage points; 95% confidence interval [CI], 4 to 20; P=0.005). MRI, with or without targeted biopsy, was noninferior to standard biopsy, and the 95% confidence interval indicated the superiority of this strategy over standard biopsy. Fewer men in the MRI-targeted biopsy group than in the standard-biopsy group received a diagnosis of clinically insignificant cancer (adjusted difference, -13 percentage points; 95% CI, -19 to -7; P<0.001). Conclusions The use of risk assessment with MRI before biopsy and MRI-targeted biopsy was superior to standard transrectal ultrasonography-guided biopsy in men at clinical risk for prostate cancer who had not undergone biopsy previously. (Funded by the National Institute for Health Research and the European Association of Urology Research Foundation; PRECISION ClinicalTrials.gov number, NCT02380027 .)

Landuse and soil degradation in the southern Maya lowlands, from Pre-Classic to Post-Classic times : The case of La Joyanca (Petén, Guatemala)

International audienceThis work focuses on the impact of Maya agriculture on soil degradation. In site and out site studies in the area of the city of La Joyanca (NW Petén) show that "Maya clays" do not constitute a homogeneous unit, but represent a complex sedimentary record. A high resolution analysis leads us to document changes in rates and practices evolving in time in relation with major socio-political and economic changes. It is possible to highlight extensive agricultural practices between Early Pre-classical to Late Pre-classical times. Intensification occurs in relation with reduction of the fallow duration during Pre-classic to Classic periods. The consequences of these changes on soil erosion are discussed. However, it does not seem that the agronomic potential of the soils was significantly degraded before the end of the Classic period

Telemedicine and international disaster response: Medical consultation to Armenia and Russia via a telemedicine spacebridge

The Telemedicine Spacebridge, a satellite mediated audio-video-fax link between four U.S. and two Armenian and Russian medical centers, permitted remote American consultants to assist Armenian and Russian physicians in the management of medical problems following the December 1988 earthquake in Armenia and the June 1989 gas explosion near Ufa. During 12 weeks of operations, 247 Armenian and Russian and 175 American medical professionals participated in 34 half-day clinical conferences. 209 patients were discussed, requiring expertise in 20 specialty areas. Telemedicine consultations resulted in altered diagnoses for 54, new diagnostic studies for 70, altered diagnostic processes for 47, and modified treatment plans for 47 of 185 Armenian patients presented. Simultaneous participation of several U.S. medical centers was judged beneficial; quality of data transmission was judged excellent. These results suggest that interactive consultation by remote specialists can provide valuable assistance to onsite physicians and favorably influence clinical decisions in the aftermath of major disasters

Semantics in active surveillance for men with localized prostate cancer - results of a modified Delphi consensus procedure

Active surveillance (AS) is broadly described as a management option for men with low-risk prostate cancer, but semantic heterogeneity exists in both the literature and in guidelines. To address this issue, a panel of leading prostate cancer specialists in the field of AS participated in a consensus-forming project using a modified Delphi method to reach international consensus on definitions of terms related to this management option. An iterative three-round sequence of online questionnaires designed to address 61 individual items was completed by each panel member. Consensus was considered to be reached if >= 70% of the experts agreed on a definition. To facilitate a common understanding among all experts involved and resolve potential ambiguities, a face-to-face consensus meeting was held between Delphi survey rounds two and three. Convenience sampling was used to construct the panel of experts. In total, 12 experts from Australia, France, Finland, Italy, the Netherlands, Japan, the UK, Canada and the USA participated. By the end of the Delphi process, formal consensus was achieved for 100% (n = 61) of the terms and a glossary was then developed. Agreement between international experts has been reached on relevant terms and subsequent definitions regarding AS for patients with localized prostate cancer. This standard terminology could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.Peer reviewe

PRECISE Version 2:Updated Recommendations for Reporting Prostate Magnetic Resonance Imaging in Patients on Active Surveillance for Prostate Cancer

Background and objective: The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations standardise the reporting of prostate magnetic resonance imaging (MRI) in patients on active surveillance (AS) for prostate cancer. An international consensus group recently updated these recommendations and identified the areas of uncertainty. Methods: A panel of 38 experts used the formal RAND/UCLA Appropriateness Method consensus methodology. Panellists scored 193 statements using a 1–9 agreement scale, where 9 means full agreement. A summary of agreement, uncertainty, or disagreement (derived from the group median score) and consensus (determined using the Interpercentile Range Adjusted for Symmetry method) was calculated for each statement and presented for discussion before individual rescoring. Key findings and limitations: Participants agreed that MRI scans must meet a minimum image quality standard (median 9) or be given a score of ‘X’ for insufficient quality. The current scan should be compared with both baseline and previous scans (median 9), with the PRECISE score being the maximum from any lesion (median 8). PRECISE 3 (stable MRI) was subdivided into 3-V (visible) and 3-NonV (nonvisible) disease (median 9). Prostate Imaging Reporting and Data System/Likert ≥3 lesions should be measured on T2-weighted imaging, using other sequences to aid in the identification (median 8), and whenever possible, reported pictorially (diagrams, screenshots, or contours; median 9). There was no consensus on how to measure tumour size. More research is needed to determine a significant size increase (median 9). PRECISE 5 was clarified as progression to stage ≥T3a (median 9). Conclusions and clinical implications: The updated PRECISE recommendations reflect expert consensus opinion on minimal standards and reporting criteria for prostate MRI in AS.</p