Cytological Aspects on the Effects of a Nasal Spray Consisting of Standardized Extract of Citrus Lemon and Essential Oils in Allergic Rhinopathy

In this paper, a new formulation of nasal spray was set up based on the extract of lemon pulp, obtained by using a new solid-liquid technology of extraction, added to pure Aloe juice, soluble propoli, and essential oils of Ravensara and Niaouly. It was tested in a clinical study in which 100 subjects were recruited for a period of one month. Nasal scraping was used for collecting samples and after the application of theMay-Grunwald Giemsa standard technique, glass slides were analysed by using optical microscope with a 1000x oil immersion. A control group constituted of ten people was recruited as control and this group was administered with physiological solution (saline solution). The comparison of results obtained before and after the application of nasal spray showed a total reduction of eosinophils granulocytes and mast cells; clinical data were confirmed by improvement of clinical pictures of patients. The lemon-based nasal spray was a good alternative to conventional medicine for the treatment of perennial and seasonal allergic and vasomotor rhinopath

Aspetti citologici sugli effetti di uno spray nasale a base di limone nelle varie forme di rinite

In questo lavoro è stata valutata l’efficacia di uno spray nasale a base di un estratto di limone mediante tecnica citologica. L’estratto di polpa di limone è stato ottenuto con metodica innovativa utilizzando il Naviglio Estrattore® o Estrattore Rapido Solido-Liquido Dinamico, che permette di esaurire in tempi brevi matrici vegetali di ogni natura utilizzando anche l’acqua come solvente per l’estrazione di composti sia idrofili che lipofili. L’efficacia della formulazione dello spray nasale è stata testata su 15 pazienti di varia età e sesso eseguendo un prelievo citologico nasale, mediante nasalscraping®, sulla parte media del turbinato inferiore all’inizio della cura,durante edalla fine della cura, usando come colorazione citologica la tecnica standard di May-Grumwald Giemsa . Dalle osservazioni risulta che l’effetto antiflogistico dello spray a base di limone trova una sicura dimostrazione nella riduzione delle componenti infiammatorie osservate al rinocitogramm

Effects of the silica dust on the nasal mucosa of ceramic workers

Abstract: Background. Adverse health effects due to occupational exposures are a global public health concern and have been studied for many years. Ceramic workers are occupationally exposed to a wide range of toxic substances as they manage clay (silico-aluminous feldspar mixed with sodium, potassium salts and iron oxide). The objective of this study was to assess the presence of any inflammation or alteration of the nasal mucosa of ceramic workers by nasal cytology. Materials and methods. Twenty-eight ceramic workers from Caltagirone (Italy) were enrolled. Nasal symptoms, atopy, health habits and workplace features were assessed by a special questionnaire, and nasal mucosa health was evaluated by nasal cytology. Results. The cytological study of the nasal mucosa revealed the constant presence of abundant, thick and filamentous mucus, as well as a reorganization of the nasal cellularity with a prevalence of muciparous hyperplasia and metaplasia in the study group, and only in a lesser extent for the subjects with some protective environmental measures. Conclusions. The ceramic workers showed chronic inflammatory rhinitis on nasal cytology, with a remodelling of the nasal mucosa and thick mucus. Nasal cytology may be a helpful tool either for the health surveillance of the ceramic workers, or for the screening of any pathology of the upper airways

Adjuvant therapy with tablets containing sodium jaluronate, carbomer and xantam gum for gerd pharyngitis

Introduction: Chronic pharyngitis is one of the most frequent diseases of the upper aerodigestive pathways. Gastro-esophageal reflux plays an important role in the g this disease. In fact, the excessive exposure of the pharynx to the gastric contents leads to a chronic irritation of the upper airways. On the basis of the foregoing, the study of the present work aims to document the effect of pastilles composed of xanthan gum, sodium hyaluronate, mannitol, sodium hydrogen carbonate, sorbitol, citric acid, aspartame, vitamin C, aroma, zinc citrate dihydrate. variation of salivary pH, of the symptomatology and of the objective picture in subjects affected by secondary interest in acidity of the oral cavity. Materials and methods: 50 subjects were recruited. They were enrolled by the affiliated users to three ENT centers and supported by a gastroenterologist (Naples), 50 (25 males and 25 females) with average age of 37aa, Min 6 aa, Max 65 aa patients affected by secondary to acidity of the oral cavity. For each patient an objective examination was performed and then the salivary pH changes were evaluated, using indicator maps, and furthermore, the Reflux Symptoms Index (RSI) and Reflux Finding Scores (RFS) were administered before, during and after therapy to monitor the subjectivity of the symptomatology and the laryngeal objective picture. Results: The survey performed allowed to establish a clear improvement in all phases of the study, both as regards the effects on pH, both on the side of the symptomatology and on the laryngeal objective. Discussion: The motivation for improving the clinical condition of the subjects is due to the therapeutic properties of the substances used. In particular: the hyaluronic acid has a regenerating power of the mucosa; carbomer and Xanthana Gum have a viscoelastic behavior and contribute to the potency of ac. High molecular weight hyaluronic acid through the formation of a hydrocomplex of high tolerability mucoadhesive polymers. Conclusions: Undoubtedly it is a product capable of restoring the physiological conditions of the oral cavity and the very first airways and their use not only acts as a restoration of the physiological conditions of the oral cavity, but also as a preventive action for the appearance of local and systemic diseases

Relationship between autism and nasal cytology

Autism is a complex psychopathology caused by an abnormal neuropsychological development to which an individual is not able to self-regulate their feelings towards a coherent and correct psychomotor activity and communicative.Many factors contribute to the onset of this disease, and recent studies have highlighted, which important causes, in addition to the neuro-immunological interactions, the increased presence in the blood of inflammatory substances such as cytokines. Our research has been devoted to the identification of inflammatory cells in the nose in autistic patients by panoptic staining and microscopic observation. From the results obtained it proved the presence of a greater number of inflammatory cells in autistic subjects compared to normal individual