How useful are the stages of change for targeting interventions? randomized test of a brief intervention to reduce smoking

Objectives. To see whether the stages of change are useful for targeting a brief intervention to reduce smoking based on implementation intentions. A second objective was to rule out demand characteristics as an alternative explanation for the findings of intervention studies based on the transtheoretical model and implementation intentions. Design. Participants (N = 350) were randomized to a passive control condition (questionnaire only), active control condition (questionnaire-plus-instruction to plan to quit) or experimental condition (questionnaire, plan to quit, form an implementation intention). Their behavior and psychosocial orientation to quit were measured at baseline and 2-month follow-up. Main Outcome Measures. Theory of planned behavior variables, nicotine dependence and quitting. Results. Significantly more people quit smoking in the experimental condition than in the control conditions, and the planning instructions changed intention to quit and perceived control over quitting, but not behavior. Stage of change moderated these effects such that implementation intentions worked best for individuals who were in the preparation stage at baseline. Conclusion. Harnessing both motivational and volitional processes seems to enhance the effectiveness of smoking cessation programs, although further work is required to clarify inconsistencies in the literature using the stages of change.</p

Identity, environment and mental wellbeing in the veterinary profession

Mental health and career dissatisfaction are of increasing concern to the veterinary profession. The influence of identity on the psychological wellbeing of veterinarians has not been widely explored. Twelve recent veterinary graduates were enrolled in a private social media discussion group, and their identities investigated through narrative inquiry: a methodology which enables identity priorities to be extrapolated from stories of experience. Two distinct variants of the veterinary identity were identified: an academic, ‘diagnosis-focused’ identity, which prioritised definitive diagnosis and best-evidence treatment; and a broader ‘challenge-focused’ identity, where priorities additionally included engaging with the client, challenging environment or veterinary business. Contextual challenges (such as a client with limited finances or difficult interpersonal interactions) were seen as a source of frustration for those with a diagnosis-focused identity, as they obstructed the realisation of identity goals. Overcoming these challenges provided satisfaction to those with a challenge-focused identity. The employment environment of the graduates (general veterinary practice) provided more opportunities for those with a challenge-focused identity to realise identity goals, and more markers of emotional wellbeing were apparent in their stories. Markers of poor emotional health were evident in the stories of those with a diagnosis-focused identity

Massive planet migration: Theoretical predictions and comparison with observations

We quantify the utility of large radial velocity surveys for constraining theoretical models of Type II migration and protoplanetary disk physics. We describe a theoretical model for the expected radial distribution of extrasolar planets that combines an analytic description of migration with an empirically calibrated disk model. The disk model includes viscous evolution and mass loss via photoevaporation. Comparing the predicted distribution to a uniformly selected subsample of planets from the Lick / Keck / AAT planet search programs, we find that a simple model in which planets form in the outer disk at a uniform rate, migrate inward according to a standard Type II prescription, and become stranded when the gas disk is dispersed, is consistent with the radial distribution of planets for orbital radii 0.1 AU < a < 2.5 AU and planet masses greater than 1.65 Jupiter masses. Some variant models are disfavored by existing data, but the significance is limited (~95%) due to the small sample of planets suitable for statistical analysis. We show that the favored model predicts that the planetary mass function should be almost independent of orbital radius at distances where migration dominates the massive planet population. We also study how the radial distribution of planets depends upon the adopted disk model. We find that the distribution can constrain not only changes in the power-law index of the disk viscosity, but also sharp jumps in the efficiency of angular momentum transport that might occur at small radii.Comment: ApJ, in press. References updated to match published versio

Single-Cell Enumeration of an Uncultivated TM7 Subgroup in the

Specific oligonucleotide hybridization conditions were established for single-cell enumeration of uncultivated TM7 and IO25 bacteria by using clones expressing heterologous 16S rRNA. In situ analysis of human subgingival crevice specimens revealed that a greater proportion of samples from sites of chronic periodontitis than from healthy sites contained TM7 subgroup IO25. In addition, IO25 bacterial cells from periodontitis site samples were more abundant and fourfold longer than IO25 cells from healthy site samples

MHD simulations of the collapsar model for GRBs

We present results from axisymmetric, time-dependent magnetohydrodynamic (MHD) simulations of the collapsar model for gamma-ray bursts. Our main conclusion is that, within the collapsar model, MHD effects alone are able to launch, accelerate and sustain a strong polar outflow. We also find that the outflow is Poynting flux-dominated, and note that this provides favorable initial conditions for the subsequent production of a baryon-poor fireball.Comment: 4 pages, to appear in proceedings of "2003 GRB Conference" (Santa Fe, NM, September 8-12, 2003), needs aipprocs LaTeX class, movies are available at http://rocinante.colorado.edu/~proga

Reduction of Effective Terahertz Focal Spot Size By Means Of Nested Concentric Parabolic Reflectors

An ongoing limitation of terahertz spectroscopy is that the technique is generally limited to the study of relatively large samples of order 4 mm across due to the generally large size of the focal beam spot. We present a nested concentric parabolic reflector design which can reduce the terahertz focal spot size. This parabolic reflector design takes advantage of the feature that reflected rays experience a relative time delay which is the same for all paths. The increase in effective optical path for reflected light is equivalent to the aperture diameter itself. We have shown that the light throughput of an aperture of 2 mm can be increased by a factor 15 as compared to a regular aperture of the same size at low frequencies. This technique can potentially be used to reduce the focal spot size in terahertz spectroscopy and enable the study of smaller samples

Lifetime cost effectiveness of simvastatin in a range of risk groups and age groups derived from a randomised trial of 20,536 people

&lt;i&gt;Objectives&lt;/i&gt;: To evaluate the cost effectiveness of 40 mg simvastatin daily continued for life in people of different ages with differing risks of vascular disease. Design A model developed from a randomised trial was used to estimate lifetime risks of vascular events and costs of treatment and hospital admissions in the United Kingdom. &lt;i&gt;Setting&lt;/i&gt;: 69 hospitals in the UK. &lt;i&gt;Participants&lt;/i&gt;: 20 536 men and women (aged 40-80) with coronary disease, other occlusive arterial disease, or diabetes. &lt;i&gt;Interventions&lt;/i&gt;: 40 mg simvastatin daily versus placebo for an average of 5 years. &lt;i&gt;Main&lt;/i&gt; &lt;i&gt;outcome&lt;/i&gt; &lt;i&gt;measures&lt;/i&gt;: Cost effectiveness of 40 mg simvastatin daily expressed as additional cost per life year gained. Major vascular event defined as non-fatal myocardial infarction or death from coronary disease, any stroke, or revascularisation procedure. Results were extrapolated to younger and older age groups at lower risk of vascular disease than were studied directly, as well as to lifetime treatment. &lt;i&gt;Results&lt;/i&gt;: At the April 2005 UK price of £4.87 (&#8364;7; $9) per 28 day pack of generic 40 mg simvastatin, lifetime treatment was cost saving in most age groups and vascular disease risk groups studied directly. Gains in life expectancy and cost savings decreased with increasing age and with decreasing risk of vascular disease. People aged 40-49 with 5 year risks of major vascular events of 42% and 12% at start of treatment gained 2.49 and 1.67 life years, respectively. Treatment with statins remained cost saving or cost less than £2500 per life year gained in people as young as 35 years or as old as 85 with 5 year risks of a major vascular event as low as 5% at the start of treatment. &lt;i&gt;Conclusions&lt;/i&gt;: Treatment with statins is cost effective in a wider population than is routinely treated at present

The Conundrum Confronting Congress: The Patent System Must Be Left Untouched While Being Radically Reformed, 5 J. Marshall Rev. Intell. Prop. L. 268 (2006)

Patent systems reforms have been recommended by a variety of interests, including the Federal Trade Commission and the National Academies of Science and the private sector. Although calls for radical reforms have undeniable merit, the effectiveness of the existing patent system as an incentive to investment in innovation must be left untouched in the reform process. Unwise reforms include awarding patent injunctions only sparingly and limiting patent damages to nominal amounts for inventions relating to patentable combinations made of existing components. There are, however, “three pillars” that should guide reform: (1) introduce full transparency and objectiveness into the tests for determining patent validity; (2) create comprehensive post-issuance patent revocation procedures; and (3) establish incentives for inventors to obtain fully valid patents by eliminating the “inequitable conduct” defense for such valid patents. Further, the current nineteenth-century patent examining paradigm should be changed to reflect the twenty-first century realities. The new paradigm should demand increased patent applicant responsibility and increased patent examiner accountability

Now That the Courts Have Beaten Congress to the Punch, Why is Congress Still Punching the Patent System?

The U.S. House of Representatives began September by passing the Patent Reform Act of 2007. This bill, if enacted, would make major changes to U.S. patent law. Given the universally recognized need for improvements to the U.S. patent system, passing a patent reform bill in the House should have been easy. It was not. The Patent Reform Act of 2007 made it through the House only after a spirited debate. There were a host of complaints by House members that the bill was not ready for floor action. In the end, it passed the House by a relatively narrow margin, 220 members voting for the bill and 175 members voting against. What made for such tough congressional sledding