Rotating hybrid compact stars

Starting from equations of state of nucleonic and color-superconducting quark matter and assuming a first-order phase transition between these, we construct an equation of state of stellar matter, which contains three phases: a nucleonic phase, as well as two-flavor and three-flavor color-superconducting phases of quarks. Static sequences of the corresponding hybrid stars include massive members with masses of $\sim 2 M_{\odot}$ and radii in the range of $13< R < 16$ km. We investigate the integral parameters of rapidly rotating stars and obtain evolutionary sequences that correspond to constant rest-mass stars spinning down by electromagnetic and gravitational radiation. Physically new transitional sequences are revealed that are distinguished by a phase transition from nucleonic to color-superconducting matter for some configurations that are located between the static and Keplerian limits. The snapshots of internal structure of the star, displaying the growth or shrinkage of superconducting volume as the star's spin changes, are displayed for constant rest mass stars. We further obtain evolutionary sequences of rotating supramassive compact stars and construct pre-collapse models that can be used as initial data to simulate a collapse of color-superconducting hybrid stars to a black hole.Comment: 9 pages, 9 figures; v2: minor improvements, matches published version, v3: corrected figure placemen

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

Numerous inflammatory and innate immune pathways are involved in atherogenesis. Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. Familial Mediterranean fever (FMF) is a chronic inflammatory disorder with profiles of inflammatory markers close to that seen in the general population. In a few recent studies, it has been shown that endothelial dysfunction, increased atherosclerotic burden and activation of platelets accompany attack-free periods of FMF. Colchicine is proved to be useful in suppression of inflammation in FMF. Preliminary basic and clinical studies suggest that this relatively safe drug may be useful for cardiovascular protection in patients with FMF and in the general population. Multinational prospective studies are warranted to further elaborate clinical model of inflammation-induced atherosclerosis associated with FMF

[(4-Dimethyl­amino-2-methyl-5-phenyl­furan-3-yl)meth­yl]diethyl­methyl­aza­nium iodide

In the title compound, C19H29N2O+·I−, the dihedral angle between the mean planes of the essentially planar furan (r.m.s. deviation = 0.007 Å) and phenyl rings is 48.4 (1)°. In the crystal, cations and anions are arranged in layers lying parallel to (100)

1-Benzyl-2-(1H-indol-3-yl)-5-oxo­pyrrolidine-2-carbonitrile

In the title compound, C20H17N3O, a potential anti-human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse-transcriptase inhibitor, the pyrrolidine ring has an envelope conformation. In the crystal structure, adjacent mol­ecules are connected into infinite chains via an N—H⋯O hydrogen bond

7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

The title compound, C18H15ClN2O2, is a potential human immunodeficiency virus type-1 (HIV-1) non-nucleoside reverse transcriptase inhibitor. The pyrrolidine ring adopts an envelope and the diazepine ring a boat conformation. In the crystal structure, two isomers (R and S) form centrosymmetric dimers via N—H⋯O hydrogen bonds

Crystal structure of 2-(1,3,7,9-tetramethyl-2,4,6,8-tetraoxo-1,2,3,4,6,7,8,9-octahydropyrido[2,3-d:6,5-d′]dipyrimidin-5-yl)benzamide dimethylformamide hemisolvate

The title compound, C20H18N6O5·0.5C3H7NO, crystallized as a dimethylformamide (DMF) solvate. In the main molecule, the dihedral angle between the pyridodipyrimidine fused-ring system and the benzamide substituent is 82.26 (11)°. In the crystal, the benzamide molecules are linked by N—H...O hydrogen bonds to generate tetramers with an approximate square-prismatic shape, which appears to correlate with the tetragonal crystal symmetry. The DMF molecule is disordered about a crystallographic twofold axis and accepts a C—H...O interaction from the benzamide molecule

Open access: Changing global science publishing

The article reflects on open access as a strategy of changing the quality of science communication globally. Successful examples of open-access journals are presented to highlight implications of archiving in open digital repositories for the quality and citability of research output. Advantages and downsides of gold, green, and hybrid models of open access operating in diverse scientific environments are described. It is assumed that open access is a global trend which influences the workflow in scholarly journals, changing their quality, credibility, and indexability