Representing continuous t-norms in quantum computation with mixed states

A model of quantum computation is discussed in (Aharanov et al 1997 Proc. 13th Annual ACM Symp. on Theory of Computation, STOC pp 20–30) and (Tarasov 2002 J. Phys. A: Math. Gen. 35 5207–35) in which quantum gates are represented by quantum operations acting on mixed states. It allows one to use a quantum computational model in which connectives of a four-valued logic can be realized as quantum gates. In this model, we give a representation of certain functions, known as t-norms (Menger 1942 Proc. Natl Acad. Sci. USA 37 57–60), that generalize the triangle inequality for the probability distributionvalued metrics. As a consequence an interpretation of the standard operations associated with the basic fuzzy logic (H´ajek 1998 Metamathematics of Fuzzy Logic (Trends in Logic vol 4) (Dordrecht: Kluwer)) is provided in the frame of quantum computatio

A Scan-to-BIM Approach for the Management of Two Arab-Norman Churches in Palermo (Italy)

The paper shows the results of the research activities carried out by the Department of Engineering at the University of Palermo (Italy), which assessed the application of the Heritage Building Information Modelling (HBIM) methodology through a Scan-to-BIM approach to two local churches belonging to the medieval period. This project was motivated by a renewed interest from the city administrators towards the conservation of cultural heritage dating back to the Arab-Norman domination in Sicily since one of the two buildings was included in the UNESCO World Heritage Sites list in 2015. The morpho-typological style of the churches has been acquired by high-detailed 3D surveys, which provided the base for two HBIM models suited to render the peculiarity of these buildings at their best. The BIM environment allowed both the geometrical representation of all the architectural elements and their further enrichment with the integration of non-geometric data and semantic signification through a knowledge-based workflow. This process led to a hierarchical organization of two high-accuracy digital replicas and to the creation of a database containing all of the architectural items typical of the Arab-Norman style, aimed to share the awareness of its conservation and to match all of the Cultural Heritage requirements. In the future, the features in this database can be shared with other specialists as reference objects for further studies on cultural heritage sites in the UNESCO list

Cross-Flow turbine design for variable operating conditions

The potential energy hidden in water resources is becoming more and more a significant economic value. The value of the hydroelectric energy is often magnified by the proximity of the turbine to pumps or other energy sinks owned by the same water manager. Cross-flow or Banki-Michel turbines are a very efficient and economic choice that allows a very good cost/benefit ratio for energy production located at the end of conduits carrying water from a water source to a tank. In the paper the optimum design of a cross-flow turbine is sought after, assuming a flow rate variable in time. Regulation of the discharge entering in the turbine is a key issue, which is faced adopting a shaped semicircular segment, moved inside the main case around the rotating impeller. The maximum efficiency of the turbine is attained by setting the velocity of the particles entering the impeller at about twice the velocity of the rotating system at the impeller inlet. If energy losses along the pipe are negligible, closing and opening the inlet surface with the semicircular segment allows always a constant hydraulic head and a constant velocity at the impeller inlet, even with different flow rate entering values. Observed reduction of the turbine efficiency along with the inlet surface reduction is first investigated; a design methodology, using also CFD simulations, is then proposed; finally, the same methodology is applied to a real site in Sicily, selected in the context of the HYDROENERGY P.O. - F.E.S.R. European project

Lessons in learning gain: insights from a pilot project

‘Learning gain’ has become an increasingly prominent concept in debates about the effectiveness of higher education across OECD countries. In England, interest has been heightened by the Higher Education Funding Council for England (HEFCE)’s major research initiative on learning gain, launched in 2015, and by the new Teaching Excellence Framework which assesses learning and teaching and student outcomes. HEFCE’s novel research initiative has funded a set of experimental projects across the English higher education sector for the first time. This paper presents preliminary findings from one such project at the University of East Anglia (UEA). The project trials and evaluates three approaches to identifying and measuring learning gain using data from cohorts of students across different discipline areas during 2015–2016 and 2016–2017. It builds upon previous work carried out at UEA in developing self-efficacy assessments and applying concept inventories. Student marks provide a simple comparator as a third approach to measuring learning gain

A single amino acid change A19V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?

We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perform. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL

Synthesis of a [2]rotaxane through first- and second-sphere coordination

In an effort to expand the application of a new template from interpenetrated to interlocked molecular species, we report the synthesis of a new [2]rotaxane by means of both first- and second-sphere coordination of a palladium(II) dichloride subunit

Impeller optimization in crossflow hydraulic turbines

Crossflow turbines represent a valuable choice for energy recovery in aqueducts, due to their constructive simplicity and good efficiency under variable head jump conditions. Several experimental and numerical studies concerning the optimal design of crossflow hydraulic turbines have already been proposed, but all of them assume that structural safety is fully compatible with the sought after geometry. We show first, with reference to a specific study case, that the geometry of the most efficient impeller would lead shortly, using blades with a traditional circular profile made with standard material, to their mechanical failure. A methodology for fully coupled fluid dynamic and mechanical optimization of the blade cross-section is then proposed. The methodology assumes a linear variation of the curvature of the blade external surface, along with an iterative use of two-dimensional (2D) computational fluid dynamic (CFD) and 3D structural finite element method (FEM) simulations. The proposed methodology was applied to the design of a power recovery system (PRS) turbine already installed in an operating water transport network and was finally validated with a fully 3D CFD simulation coupled with a 3D FEM structural analysis of the entire impeller

Array-based comparative genomic hybridization analysis reveals chromosomal copy number aberrations associated with clinical outcome in canine diffuse large B-cell lymphoma

Canine Diffuse Large B-cell Lymphoma (cDLBCL) is an aggressive cancer with variable clinical response. Despite recent attempts by gene expression profiling to identify the dog as a potential animal model for human DLBCL, this tumor remains biologically heterogeneous with no prognostic biomarkers to predict prognosis. The aim of this work was to identify copy number aberrations (CNAs) by high-resolution array comparative genomic hybridization (aCGH) in 12 dogs with newly diagnosed DLBCL. In a subset of these dogs, the genetic profiles at the end of therapy and at relapse were also assessed. In primary DLBCLs, 90 different genomic imbalances were counted, consisting of 46 gains and 44 losses. Two gains in chr13 were significantly correlated with clinical stage. In addition, specific regions of gains and losses were significantly associated to duration of remission. In primary DLBCLs, individual variability was found, however 14 recurrent CNAs (>30%) were identified. Losses involving IGK, IGL and IGH were always found, and gains along the length of chr13 and chr31 were often observed (>41%). In these segments, MYC, LDHB, HSF1, KIT and PDGFR alpha are annotated. At the end of therapy, dogs in remission showed four new CNAs, whereas three new CNAs were observed in dogs at relapse compared with the previous profiles. One ex novo CNA, involving TCR, was present in dogs in remission after therapy, possibly induced by the autologous vaccine. Overall, aCGH identified small CNAs associated with outcome, which, along with future expression studies, may reveal target genes relevant to cDLBCL

Reaction of the Ambident Electrophile Dimethyl Carbonate with the Ambident Nucleophile Phenylhydrazine

To explore the ambident electrophilic reactivity of dimethyl carbonate (DMC), reactions with the ambident nucleophile phenylhydrazine were investigated. When a Brönsted base was used, selective carboxymethylation occurred at N-1, after that several other compounds were produced selectively utilizing various conditions. Formation of these compounds was explained by using the Hard−Soft Acid−Base (HSAB) theory. Catalysis by some metal salts altered the reactivity of phenylhydrazine, which effected selective carboxymethylation at N-2 of phenylhydrazine instead

Sarcopenia Does Not Worsen Survival in Patients With Cirrhosis Undergoing Transjugular Intrahepatic Portosystemic Shunt for Refractory Ascites

INTRODUCTION: The impact of sarcopenia in patients undergoing transjugular intrahepatic portosystemic shunt (TIPSS) insertion for refractory ascites is unknown. METHODS: All adult patients who underwent TIPSS insertion for refractory ascites between 2010 and 2018 were included. Skeletal muscle index at L3 was used to determine sarcopenia status. RESULTS: One hundred seven patients were followed for 14.2 months. Sarcopenia was present in 57% of patients. No patient had history of pre-TIPSS hepatic encephalopathy (HE). De novo HE occurred in 30% of patients. On multivariate analysis, only platelet count and L3-SMI predicted de novo HE. On multivariate analysis, age and model for end-stage liver disease with sodium predicted mortality, whereas L3-SMI and sarcopenia did not. In patients with repeat imaging, L3-SMI improved significantly post-TIPSS compared with baseline. DISCUSSION: Sarcopenia should not be considered as a contraindication to TIPSS insertion in refractory ascites because it is not associated with de novo HE or increased mortality