132 research outputs found
The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases
The Supplementary Material for this article can be found online
at: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1191782/
full#supplementary-materialInterleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology is highest between IL-17A and IL-17F, displaying certain overlapping functions. In general, IL-17A and IL-17F play important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections, and signaling mainly through activation of the nuclear factor-kappa B (NF-κB) pathway. The role of IL-17A and IL-17F has been established in chronic immune-mediated inflammatory diseases (IMIDs), such as psoriasis (PsO), psoriatic arthritis (PsA), axial spondylarthritis (axSpA), hidradenitis suppurativa (HS), inflammatory bowel disease (IBD), multiple sclerosis (MS), and asthma. CD4+ helper T cells (Th17) activated by IL-23 are well-studied sources of IL-17A and IL-17F. However, other cellular subtypes can also produce IL-17A and IL-17F, including gamma delta (γδ) T cells, alpha beta (αβ) T cells, type 3 innate lymphoid cells (ILC3), natural killer T cells (NKT), or mucosal associated invariant T cells (MAIT). Interestingly, the production of IL-17A and IL-17F by innate and innate-like lymphocytes can take place in an IL-23 independent manner in addition to IL-23 classical pathway. This would explain the limitations of the inhibition of IL-23 in the treatment of patients with certain rheumatic immune-mediated conditions such as axSpA. Despite their coincident functions, IL-17A and IL-17F contribute independently to chronic tissue inflammation having somehow non-redundant roles. Although IL-17A has been more widely studied, both IL-17A and IL-17F are overexpressed in PsO, PsA, axSpA and HS. Therefore, dual inhibition of IL-17A and IL-17F could provide better outcomes than IL-23 or IL-17A blockade.UCB Pharma S
Detección dermatológica de COVID-19
En conclusión, la población juvenil debe conocer estas
manifestaciones cutáneas para tomar consciencia y evitar la
propagación del virus entre la población. Es necesario
conocer los mecanismos fisiopatológicos del virus y su
afectación en la piel para poder hacer un tratamiento dirigido
y orientado a aliviar la posible sintomatología asociada.
Todavía no existe evidencia de las posibles consecuencias de
estas manifestaciones
Perceptions of medical students toward teledermatology as an educational tool: a cross-sectional study
Introduction: Teledermatology consultations have recently been on the rise,
especially due to the SARS-CoV-2 pandemic. The role of teledermatology has
been extensively discussed as a mean for the education of dermatology residents.
Nevertheless, little has been explored on its use as a pedagogical tool for medical
students. The objectives of this study were to assess the level of satisfaction of
medical students with teledermatology and to evaluate their opinion about its use
as an educational tool.
Methods: A cross-sectional study was carried out at the Dermatology Department,
Hospital Universitario Virgen de las Nieves, Granada (Spain). Participants were
fourth-year medical students. Every student would spend half of their internship
in face-to-face consultations and the other half in teledermatology consultations.
Data was collected via self-administered questionnaires.
Results: Eighty one students were finally surveyed, being 66.67% (73/81) female.
A majority of students considered a mixed clinical internship model (face-toface
consultations combined with teledermatology) more suitable for obtaining
higher marks in the subject of dermatology and in the Medical Intern Resident
exam (p = 0.04). Nevertheless, face-to-face practice was considered more useful
for their training as general practitioners (p = 0.04).
Conclusion: Despite the fact that students highly value doctor-patient relationship,
teledermatology is considered a powerful educational tool
Study of the Exposome Ageing-related Factors in the Spanish Population
The authors thank Dr Almudena Fuster-Manzano and Dr Blanca
Piedrafita for providing scientific support.To characterize the exposome of the Spanish population
and its association with skin ageing a cross-sectional
epidemiological study was conducted in men
and women (18–60 years old). A total of 1,474 participants
were included. Mean age (± standard deviation)
was 40.84 ± 10.26 years. Most participants had
Fitzpatrick skin phototype II (44.1%) and skin ageing
in accordance with their current age (69.0%). In the
logistic model, age, smoking habit, use of sunscreen
and use of cosmetics were all significant independent
predictors of skin ageing. Thus, tobacco consumption
increased the score of the model towards presenting
skin ageing above that expected for age, while the opposite
occurred with the use of sunscreen and a complete
skin care routine. The exposome therefore has
an impact on skin ageing, with age, smoking habit,
use of sunscreen and the use of cosmetics identified
as predictors of skin ageing. Skin care routines and
sunscreen use may help to prevent this process.Vich
Quality of Life in Cohabitants of Patients with Hidradenitis Suppurativa: A Cross-sectional Study
The following are available online at http://www.mdpi.com/1660-4601/17/16/6000/s1,
Table S1: Sociodemographic variables of patients and cohabitants; Table S2: Clinical variables of patients with
hidradenitis suppurativa.Hidradenitis suppurativa (HS) is a chronic inflammatory disease that impairs patients’ physical and mental health. However, few studies have considered the consequences of HS on cohabitants. The aims of this study were to explore the impact of HS on the quality of life (QOL) of cohabitants and to assess potentially associated factors. A cross-sectional study was conducted and patients with HS and their cohabitants were invited to participate. Validated questionnaires were used to measure QOL, anxiety and depression, type D personality and sexual dysfunction. The clinical variables of patients and the demographic characteristics of cohabitants were also collected. Twenty-seven patients and 27 cohabitants were included for analysis. Patients and cohabitants presented significant QOL impairment. A direct association was found between the Dermatology Life Quality Index (DLQI) and the Familiar Dermatology Life Quality Index (FDLQI). DLQI scores were associated with the presence of negative affectivity, a trait typical of type D personality, as well as with cohabitants’ anxiety. FDLQI scores were associated with cohabitant anxiety and patient depression. Hidradenitis suppurativa damages quality of life in patients and cohabitants. Identifying potential psychological factors could help us to recognize at-risk patients and apply personalized treatments for them and their environment
How to... Revisar un artículo científico
Uno de los pilares básicos de la publicación científica
contemporánea es la denominada “revisión por pares”
o “peer-review”. Si usted ha sido elegido como revisor
de uno de los artículos enviados para su publicación
en Archivos de Medicina Univeristaria, es debido a
que es usted un “par” del autor de dicho trabajo,
es decir, una persona con un nivel de formación y
experiencia investigadora semejante y equiparable.
Además, en opinión del Comité Editorial de AMU,
usted atesora un nivel de conocimiento y experiencia
sobre la temática del artículo en revisión que hacen
que su opinión sobre el mismo sea inestimable
Frontal Fibrosing Alopecia: A Review
This article is part of the Ph.D. thesis of María Librada Porriño-Bustamante.Frontal fibrosing alopecia is a scarring alopecia, the prevalence of which is increasing worldwide since its first description in 1994. The reason for this emerging epidemic may be a higher exposure to an unknown trigger, although its aethiology and pathogenesis still remain enigmatic. Clinical, trichoscopic, sonographic, and histopathologic findings are allowing clinicians to understand more aspects about this type of cicatricial alopecia. Several treatments have been used in frontal fibrosing alopecia, although the 5-alpha reductase inhibitors seem to be the most promising. The aim of this report is to provide a compilation about the published data regarding frontal fibrosing alopecia in a narrative review
Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima‐Media Thickness in Patients with Severe Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been
associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study
is to assess cardiovascular risk by means of intima‐media thickness (IMT), metabolic syndrome, and
other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for
biologic therapy and to explore potentially associated factors. A cross‐sectional study was
performed. Body mass index (BMI), carotid intima‐media thickness (IMT), and blood tests,
including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were
performed. Fifty patients were included in the study; the male/female ratio was 3:2. The mean age
was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 μm.
A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was
observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose
levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion,
patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within
the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be
useful clinical and biochemical markers to identify patients at higher risk
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