Lipodystrophy and muscle hypertrophy

23rd International Annual Congress of the World-Muscle-Society (WMS) -- OCT 02-06, 2018 -- Mendoza, ARGENTINAWOS: 000449126600370World Muscle So

MRI evaluation of patellar tendon defect after harvesting its central third

WOS: 000221828300011PubMed ID: 15145490Purpose: the purpose of this study was to evaluate defect width of patellar tendon after harvest for anterior cruciate ligament reconstruction. Materials and methods: we performed MRI at various time interval after graft harvest (2-96 months) on 28 patients who had had reconstruction of the anterior cruciate ligament using mid-third patellar tendon. T1 and T2 weighted axial images were obtained to assess donor site defect of the patellar tendon. Measurement of the defect width was performed at the level of menisci on the axial images. The patients were divided into two groups according to the time interval between operation and imaging. The defect width of patients with short time interval (2-12 months) was compared to the defect width of patients with long time interval (12-96 months). Results: the average defect width of patients with short time interval was 6.4 mm and it was 2.2 rum for the patients with long time interval. Decreased defect width was obtained from MRI images in the patients with long time interval. Closed donor site defect was detected in I out of 14 patients with short time interval and 6 out of 14 patients with long time interval. Discussion and conclusion: these results show that there is no complete closure of donor site defect up to I year. However, it seems to be nearly complete Closure of patellar tendon defect in the long time period. (C) 2003 Elsevier Ireland Ltd. All rights reserved

Primary osteosarcoma arising from subcutaneous tissue: 5-year follow-up

PubMed ID: 22726985Extraskeletal osteosarcomas are extremely rare, high-grade neoplasms. Approximately 300 cases have been reported in the literature, with a 5-year survival of around 25%-37%. Extraskeletal osteosarcomas frequently arise from lower-extremity, deep soft tissue planes, including hemorrhagic, necrotic areas. While primary osteosarcomas have been observed in the first two decades of life, osteosarcomas arising from the skeletal system are rarely observed before 40 years of age. We present radiological findings of an osteosarcoma case arising from cruris subcutaneous tissue in a young adult (31 years old) at diagnosis and at the follow-up period during a 5-year monitoring process. Additionally, we reviewed the literature regarding this case. © 2012 Elsevier Inc

Bone mineral density in mild and advanced ankylosing spondylitis

WOS: 000183950300003PubMed ID: 12833574To compare the bone mineral density (BMD) and determine the frequency of osteoporosis in mild and advanced ankylosing spondylitis (AS) cases. Seventy three patients with AS were enrolled in this study. The BMD was analyzed at the lumbar spine and hip by dual energy X-ray absorptiometry. The patients were diagnosed as being "normal, osteopenia, or osteoporosis" according to the WHO classification. Using the BASRI-lumbar and BASRI-hip scores, the patients were grouped in mild and advanced AS categories. The mean BMD in the lumbar spine and hip of patients with mild and advanced AS was similar (p>0.05). While 61.6% of the patients were found to have osteopenia or osteoporosis in the lumbar spine, 46.6% had osteopenia or osteoporosis in the total hip. Of the patients with advanced AS 54.3% had osteopenia or osteoporosis in the lumbar spine, 75% in the total hip. Of the patients with mild AS patients had 68.4% osteopenia or osteoporosis in the lumbar spine, and 42.3% in the total hip. The osteopenia or osteoporosis frequency of the mild and advanced cases of AS in the lumbar spine was similar (p>0.05). In the advanced AS patients, osteopenia or osteoporosis frequency was significantly higher in the total hip than in the mild AS patients (p<0.05). In conclusion, there was evidence of osteoporosis in both the advanced AS and mild AS patients. The reason why the anteroposterior lumbar DXA results in the advanced AS patients were similar to the mild ones may be due to the existence of syndesmophytes and ligament calcification. In these cases, it is more convenient to use a hip DXA for assessing the extent of osteoporosis

Muscle MRI findings in spinal muscular atrophy type 3

22nd International Annual Congress of the World-Muscle-Society (WMS) -- OCT 03-07, 2017 -- Saint Malo, FRANCEWOS: 000412961500095World Muscle So

Pitfalls in evaluating neoadjuvant chemotherapy response in bone resection specimens

WOS: 00031036480164

Feasibility and clinical utility of intraoperative consultation with frozen section in osseous lesions

PubMed ID: 22772767Intraoperative consultation (IOC) with frozen section (FS) allows the surgeon to make therapy decisions during the operation.However, there is relatively little information on the use of IOC in skeletal lesions. We performed a retrospective study to examine the indications for IOC and compare the histological findings of FS and permanent paraffin section (PS) results to determine its clinical benefits. Ninety-seven consecutive cases evaluated between 2008 and 2011 were retrieved from IOC archives of our Pathology Department. In 79 % of the cases, there was no prior core needle biopsy (CNB), and IOC was performed to confirm the clinical or radiological diagnosis. In 5 (5 %) cases, no definitive result could be obtained with FS, and diagnosis was deferred. The reasons for a deferred diagnosis (DD) included poor section quality in two lipomatous lesions and the sample heterogeneity in the others. When adjusted for DD, FS and PS results showed 100 % concordance in terms of discriminating "benign vs. malignant" and defining diagnostic categories as "benign non-tumoral," "benign tumoral/tumor-like, " "malignant primary tumor," "malignant metastatic tumor," or "hematopoietic malignancy." The presence of non-sclerotic osseous tissues does not have a significant adverse impact on the FS section quality and diagnosis made by FS. Thus, sections with diagnostic value can be obtained from bone lesions via FS. In this study, specific diagnoses were made in 88 % of the cases. We believe that IOC with FS can be safely performed in tertiary referral centers where there is a multidisciplinary team working in collaboration. © Springer-Verlag 2012