4,698 research outputs found
Atrial natriuretic factor (ANF) in ascites of patients with cirrhosis of the liver or with malignant neoplasms
Different behaviour of the N-terminal and C-terminal fragment of proatrial natriuretic factor in plasma of healthy subjects as well as of patients with cirrhosis
N-terminal (atrial natriuretic factor (ANF) 1-98) and C-terminal (ANF 99-126) fragments of proatrial natriuretic factor (NTA and CTA, respectively) were determined in plasma of healthy subjects adopting different postures and in patients with cirrhosis. Seven healthy subjects were investigated while seated and 30 min after assuming a horizontal position. NTA plasma concentrations increased in subjects in the horizontal position (from 734±250 (SE) fmol/ml to 9021227 fmol/ml; p<0.05). In contrast, CTA plasma concentrations remained unchanged (9.2+1.3 fmol/ml vs 8.9±1.6 fmol/ml). In 10 patients with cirrhosis of the liver, NTA concentrations were markedly (p<0.001) elevated compared to 11 healthy subjects (2334±291 fmol/ml vs 743±155 fmol/ml). However, there was no difference of CTA plasma levels between cirrhotic patients and healthy subjects (8.7±1.3 fmol/ml vs 8.2±0.9 fmol/ml). These data demonstrate changes of the plasma concentration of the N-terminal fragment of proatrial natriuretic factor by posture and in liver disease, in contrast to unchanged levels of the C-terminal fragment
Atrial natriuretic factor in plasma of patients with arterial hypertension, heart failure or cirrhosis of the liver
The effect of different water temperatures on the release of the atrial natriuretic factor (ANF) during "head out water immersion (HOI)"
Role of atrial natriuretic factor, cyclic GMP and the renin-aldosterone-system in acute volume regulation of healthy human subjects
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