The Imām of Simonstown and his diary (1904-1928)

Includes abstract.Includes bibliographical references.This thesis is a study of Imām Muḥammad Ṣāliḥ Saban and his Diary within the context of the Simonstown Muslim community that he served from 1904 until 1928. The thesis presents the Diary, transcribed, edited, and digitised, for the sake of understanding the Imām’s contribution. It examines the Diary as a reflection of one man’s witness, open to study from a number of perspectives. Firstly, it presents a background to the early Muslim presence in Simonstown and its links with the Cape slave community. It then constructs a biography of the Imām, mainly on the evidence culled from the Diary, but supplemented by secondary sources. It then turns to the Diary as the Imām’s testimony. The Diary is compared with those of other diarists, who mostly represented a European dominant-class viewpoint of Simonstown. The thesis argues that the Imām’s Diary provides another perspective on the town and its inhabitants. Finally, the study presents the Diary as an insider testimony of the Imām, his role and authority, in the Cape

Análisis, desde una perspectiva foucaultiana, del proceso judicial subsiguiente al levantameinto popular del puerto de La Orotava de 1810.

El proceso judicial que se analiza se encuentra enclavado bajo las condiciones de seguridad, poder y discursos de 1810. Asimismo, estamos ante el modo en que se trata judicialmente un levantamiento popular. Este tiene como característica fundamental la época de la situación de Canarias respecto a las condiciones políticas y sociales que acarreó la entrada de las tropas napoleónicas en la península ibérica y su repercusión en el archipiélago canario. Bajo estas condiciones el pueblo portuense hace un levantamiento en los días 6,7 y 8 de Marzo que tendrá por objetivo eliminar cualquier atisbo de afrancesamiento de la cultura y política del lugar. Tomando el Carnaval como espacio de reversibilidad, se pretende resolver la cuestión del levantamiento con una inversión de los poderes públicos del lugar. Antes de tomar en cuenta las declaraciones que recoge el documento, se ha realizado un análisis desde la perspectiva de Foucault, Austin, Searle y Wittgnestein, sobre las condiciones del lenguaje y su correspondencia con el proceso judicial. De esta manera, partiendo de Derrida y Foucault, se ha plasmado la condición archivística del propio proceso judicial de principios de S. XIX. Una vez que se producen las detenciones de los ciudadanos y ciudadanas que participaron activamente en este levantamiento, se inicia el proceso judicial. Estamos ante un archivo judicial que ha sido trascrito en su totalidad y que permite comprender las condiciones, discursos, relaciones jurídicas y morales que se desarrollan dentro del marco judicial. Se podrá observar el modo en el que las condiciones éticas, políticas y jurídicas se entrelazan en cada unos de los discursos. Los testimonios de los testigos, los discursos de los abogados, los interrogatorios a los detenidos y la propuesta de sentencias que el Juez Fiscal realiza, nos permitirá concluir cómo las condiciones de poder foucaultianas que analizan el paso del biopoder a la biopolítica tiene su repercusión concreta en este archivo judicial

La esfera celeste. Reconocimiento de astros en navegación.

En este trabajo se explica de forma sencilla y comprensible las partes que forman la esfera celeste así como sus principales puntos y líneas de referencia

Find yourself

Procederemos a desarrollar un proyecto conjunto entre: el “Centro Educativo para Personas Adultas San Cristóbal” y la “Oficina Insular del Voluntariado de Santa Cruz de Tenerife”, en el que se verán implicados todos los agentes educativos de ambas entidades, teniendo como destinatarios finales los alumnos de 4º de la ESO del Centro “San Cristobal”, mejorando con ello, su inserción en el mercado laboral con mayores expectativas y un mejor curriculum, adquiriendo nuevas competencias tras la puesta en marcha de dicho proyecto. Esta idea nace con la ilusión de mejorar las necesidades actuales de la comunidad del “Centro Educativo para Personas Adultas San Cristóbal”, así como ayudar a los destinatarios de este proyecto, sepan de la importancia que tiene realizar acciones de voluntariado. Del mismo modo se procederá al diseño de una serie de actividades en las que los destinatarios adquirirán competencias a través de nuestra propuesta de intervención pedagógica. Enriqueciéndose con las acciones de voluntariado, con el fin de mejorar su formación educativa, y que les servirá posteriormente de cara al mercado laboral.We will proceed to develop a joint project between: the "Educational Center for Adult Persons St Kitts" and the "Insular Office of the Voluntary work of Santa Cruz de Tenerife", in which there will meet implied all the educational agents of both entities, taking the pupils of 4 as final addressees of IT of the Center "San Cristóbal", improving with it, his insertion on the labor market with major expectations and a better curriculum, acquiring new competitions after the putting in march of the above mentioned project. This idea is born with the illusion of improving the current needs of the community of the "Educational Center for Adult Persons St Kitts", as well as to help the addressees of this project, know of the importance that it has to realize actions of voluntary work. In the same way one will proceed to the design of a series of activities in which the addressees will acquire competitions across our offer of pedagogic intervention. Prospering with the actions of voluntary work, in order to improve his educational formation, and that will serve them later with a view to the labor market. Key Words

Visualizing calcium flux in freely moving nematode embryos

Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Cell Press for personal use, not for redistribution. The definitive version was published in Biophysical Journal 112 (2017): 1975-1983, doi:10.1016/j.bpj.2017.02.035.The lack of physiological recordings from Caenorhabditis elegans embryos stands in stark contrast to the comprehensive anatomical and gene expression datasets already available. Using light-sheet fluorescence microscopy (LSFM) to address the challenges associated with functional imaging at this developmental stage, we recorded calcium dynamics in muscles and neurons and developed analysis strategies to relate activity and movement. In muscles, we found that the initiation of twitching was associated with a spreading calcium wave in a dorsal muscle bundle. Correlated activity in muscle bundles was linked with early twitching and eventual coordinated movement. To identify neuronal correlates of behavior, we monitored brain-wide activity with subcellular resolution and identified a particularly active cell associated with muscle contractions. Finally, imaging neurons of a well-defined adult motor circuit, we found that reversals in the eggshell correlated with calcium transients in AVA interneurons.E.A. and A.K. acknowledge support from the Grass Fellowship Program and D. C-R. and H.S. acknowledge the Whitman Fellowship program at MBL. This work was supported by the intramural research program of the National Institute of Biomedical Imaging and Bioengineering and NIH grants U01 HD075602 and R24OD016474 to D.C-R and A.K.2018-05-0

Reflective imaging improves spatiotemporal resolution and collection efficiency in light sheet microscopy

© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature Communications 8 (2017): 1452, doi:10.1038/s41467-017-01250-8.Light-sheet fluorescence microscopy (LSFM) enables high-speed, high-resolution, and gentle imaging of live specimens over extended periods. Here we describe a technique that improves the spatiotemporal resolution and collection efficiency of LSFM without modifying the underlying microscope. By imaging samples on reflective coverslips, we enable simultaneous collection of four complementary views in 250 ms, doubling speed and improving information content relative to symmetric dual-view LSFM. We also report a modified deconvolution algorithm that removes associated epifluorescence contamination and fuses all views for resolution recovery. Furthermore, we enhance spatial resolution (to <300 nm in all three dimensions) by applying our method to single-view LSFM, permitting simultaneous acquisition of two high-resolution views otherwise difficult to obtain due to steric constraints at high numerical aperture. We demonstrate the broad applicability of our method in a variety of samples, studying mitochondrial, membrane, Golgi, and microtubule dynamics in cells and calcium activity in nematode embryos.This work was supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering at the National Institutes of Health. P.L. and H.S. acknowledge summer support from the Marine Biological Laboratory at Woods Hole, through the Whitman- and Fellows- program. P.L. acknowledges support from NIH National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH) under grant number R01EB017293. C.S. acknowledges funding from the National Institute of General Medical Sciences of NIH under Award Number R25GM109439 (Project Title: University of Chicago Initiative for Maximizing Student Development [IMSD]) and NIBIB under grant number T32 EB002103. Partial funding for the computation in this work was provided by NIH grant numbers S10 RRO21039 and P30 CA14599. A.U. and I.R.-S. were supported by the NSF grant number 1607645

Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory

The Ras GTPase activating proteins (RasGAPs) are regulators of the conserved Ras/MAPK pathway. Various roles of some of the RasGAPs in learning and memory have been reported in different model systems, yet, there is no comprehensive study to characterize all gap genes in any organism. Here, using reverse genetics and neurobehavioural tests, we studied the role of all known genes of the rasgap family in C. elegans in associative learning and memory. We demonstrated that their proteins are implicated in different parts of the learning and memory processes. We show that gap-1 contribute redundantly with gap-3 to the chemosensation of volatile compounds, gap-1 plays a major role in associative learning, while gap-2 and gap-3 are predominantly required for short- and long-term associative memory. Our results also suggest that the C. elegans Ras orthologue let-60 is involved in multiple processes during learning and memory. Thus, we show that the different classes of RasGAP proteins are all involved in cognitive function and their complex interplay ensures the proper formation and storage of novel information in C. elegans

A cellular defense memory imprinted by early life toxic stress

Stress exposure early in life is implicated in various behavioural and somatic diseases. Experiences during the critical perinatal period form permanent, imprinted memories promoting adult survival. Although imprinting is widely recognized to dictate behaviour, whether it actuates specific transcriptional responses at the cellular level is unknown. Here we report that in response to early life stresses, Caenorhabditis elegans nematodes form an imprinted cellular defense memory. We show that exposing newly-born worms to toxic antimycin A and paraquat, respectively, stimulates the expression of toxin-specific cytoprotective reporters. Toxin exposure also induces avoidance of the toxin-containing bacterial lawn. In contrast, adult worms do not exhibit aversive behaviour towards stress-associated bacterial sensory cues. However, the mere re-encounter with the same cues reactivates the previously induced cytoprotective reporters. Learned adult defenses require memory formation during the L1 larval stage and do not appear to confer increased protection against the toxin. Thus, exposure of C. elegans to toxic stresses in the critical period elicits adaptive behavioural and cytoprotective responses, which do not form imprinted aversive behaviour, but imprint a cytoprotective memory. Our findings identify a novel form of imprinting and suggest that imprinted molecular defenses might underlie various pathophysiological alterations related to early life stress. © 2019, The Author(s)