Histopathological Findings in Gastrointestinal Tractus in Patients with Common Variable Immunodeficiency (CVID)

105th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology -- MAR 12-18, 2016 -- Seattle, WAWOS: 000370302501250US & Canadian Acad Patho

Primary hypoparathyroidism in a patient with common variable immunodeficiency associated enteropathy

Background. Common variable immunodeficiency (CVID) is a rare disease characterized by humoral immunodeficiency, often causing sinopulmonary and gastrointestinal infections, and may cause enteropathy in some patients, which leads to severe malnutrition and electrolyte deficiencies. Although many autoimmune diseases are seen with increased frequency in CVID patients, primary hypoparathyroidism is extremely rare

Primary hypoparathyroidism in a patient with common variable immunodeficiency associated enteropathy

Background. Common variable immunodeficiency (CVID) is a rare disease characterized by humoral immunodeficiency, often causing sinopulmonary and gastrointestinal infections, and may cause enteropathy in some patients, which leads to severe malnutrition and electrolyte deficiencies. Although many autoimmune diseases are seen with increased frequency in CVID patients, primary hypoparathyroidism is extremely rare. Case presentation. A 50-year-old man with CVID presented with diarrhea. The patient had complaints for 2 years and was cachectic. He had severe electrolyte and vitamin deficiencies that did not respond to oral treatment. The diarrhea causes such as celiac, inflammatory bowel diseases, and gastrointestinal infections were excluded and the endoscopy showed enteropathic changes in the duodenum and colon. Concomitant hypoparathyroidism was also detected in the patient with hypocalcemia despite adequate replacement. Conclusion. Parenteral therapy should be considered in the management of CVID enteropathy cases that do not respond to oral replacement. Although very rare, hypoparathyroidism should be considered in the differential diagnosis of CVID patients with treatment-resistant hypocalcemia

COVID-19 in patients with primary and secondary immunodeficiencies: a single-center experience

[No Abstract Available

Diagnostic Value of Specific IgE Analysis in Latex Allergy

WOS: 000304485200009PubMed ID: 22398567Background: The precision of the methods used to diagnose latex allergy is of great importance due to false-positive results. Neither the skin prick test (SPT) nor the latex-specific IgE assay has 100% diagnostic accuracy. We analysed the diagnostic value of latex-specific IgE by the first-ever concomitant use of the SPT and nasal provocation test (NPT). Methods: Twenty-seven latex-sensitive patients (group 1), 46 aeroallergen-sensitive patients (group 2a) and 33 healthy subjects (group 2b) participated in the study. All groups underwent an SPT with latex and aeroallergens and an NPT with latex. Latex-specific IgE and total IgE levels were measured by the ImmunoCAP assay. Results: Latex-specific IgE was positive in 92.6, 30.4 and 9.1% of groups 1, 2a and 2b, respectively. The 11 aeroallergen-sensitive patients in group 1 and all of the patients in group 2a were predominantly sensitised to pollens (grass, weed and tree) and reacted to a lesser degree to house dust mite, moulds and animal dander. Combined pollinosis was remarkably more prevalent in patients with positive latex-specific IgE in group 2a than in those with negative latex-specific IgE (p = 0.001). The NPT was positive in 84.6% of group 1 and negative in all control subjects. The sensitivity, specificity, negative predictive value and positive predictive value of the latex-specific IgE assay were 90.9, 72.2, 96.3 and 50%, respectively. Conclusion: The high rate of false-positive results for latex-specific IgE by ImmunoCAP should be taken into account when making a diagnosis of latex allergy in patients with pollinosis, especially in those sensitised to more than one pollen species. Copyright (C) 2012 S. Karger AG, Base

Arthritis as a presenting symptom in a hypogammaglobulinemic patient with thymectomy

WOS: 000243399200008PubMed ID: 1693295

Phagocytic and Oxidative Burst Activity of Neutrophils in Patients With Spinal Cord Injury

WOS: 000314563300017PubMed ID: 23022452Objective: To evaluate phagocytic activity and neutrophil oxidative burst functions in patients with spinal cord injury (SCI) because alterations in neutrophil metabolic activity can be one of the causes of immune mechanism damage contributing to repeated bacterial infections. Design: A controlled and cross-sectional study. Setting: Departments of physical medicine and rehabilitation and immunology. Participants: Patients with SCI (N=34) and 28 healthy controls. Interventions: Phagocytosis and oxidative burst in whole-blood neutrophils were assessed by flow cytometry. The percentage of phagocytizing cells after in vitro incubation with Escherichia coli, phagocytic activity (mean intensity of fluorescence [MW]) and the percentage of neutrophiloxidative burst, and the MW value of the production of reactive oxygen intermediates (ROIs) were analyzed. In addition, clinical assessment including the level of injury, American Spinal Injury Association scores, and functional status were carried out. Main Outcome Measures: Not applicable. Results: Although the percentage of E. coli phagocytizing neutrophils was not different between groups, the MW value of absorbed E. coli was significantly lower in patients with SCI than in controls (P<.05). The MW value of ROT production by neutrophils with both stimulator of phorbol 12-myristate 13-acetate and E. coli was significantly higher in patients with SCI (P<.05). Conclusions: In patients with SCI, decreased phagocytic activity of neutrophils may be a result of a regulatory mechanism to minimize the deleterious effects of increased neutrophil burst activity. Archives of Physical Medicine and Rehabilitation 2013;94:369-74 (C) 2013 by the American Congress of Rehabilitation MedicineEge UniversityEge University [03TIP019]We thank Ege University for providing the equipment and financial support for the project numbered 03TIP019. We also thank the Ege University Scientific Research Project Manager for his contributions