CSIC High Specialization Course on Cultural Heritage Intervention Models: Research, Protection, Conservation and Valorization: A training Experience from a complex research programme.

Comunicación presentada en la 18th Annual Meeting of the European Association of Archaeologists, celebrada en Helsinki del 29 de agosto al 1 de septiembre de 2012.In late 2007 the then called Ministry of Education and Science funded the Research Program on Technologies for the Conservation and Valorization of Cultural Heritage (TCP) within the CONSOLIDER -INGENIO 2010 call. In it 16 research groups take part, from the CSIC and 4 Spanish universities, articulating traditionally distant disciplines directly involved with Cultural Heritage. The base for working is the culture of cooperation and collaboration between groups in an interdisciplinary way. TCP was the only funded proposal of the call that focused on the study of Cultural Heritage. One of the main objectives of the project included training, so after valorizing different options, it was finally decided to opt for a CSIC High Specialization Course model. The aim was to create a postgraduate training strategy for preparing, in a truly specialized way, professionals with technical or scientific profile, who can become the best professionals working on cultural heritage. This course was an alternative possibility, different from formal university education. It also benefited from greater freedom in designing the course, choosing the participating teachers, and establishing the relationship between practical and theoretical aspects. This goal lies at the very foundations of the Consolider call and more specifically, also within TCP: strengthen and highlight the link between the interdisciplinary research, the professional practice and the social visibility of research through training, dissemination and knowledge transfer.Peer Reviewe

Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries

Objective: To describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain. Methods: Cases were drawn from eleven Spanish population-based cancer registries. Incidence was estimated for the period 1983-2007 and trends were evaluated using Joinpoint regression analysis. Results: The studied tumour groups accounted for 36% of total childhood cancers and 47.6% of those diagnosed in adolescence with annual rates per million of 53.5 and 89.3 respectively. In children 0 to 14 years of age, Neuroblastoma (NB) was the commonest (7.8%) followed by Soft-tissue sarcomas (STS) (6.3%), bone tumours (BT) (6.2%) and renal tumours (RT) (4.5%). NB was the most frequently diagnosed tumour before the 5th birthday, while STS and BT were the commonest at 5-9 years of age, and BT and Carcinoma and other epithelial tumours (COET) at 10-14. COET presented the highest incidence in adolescents, followed by germ-cell tumours (GCT), BT and STS. These four diagnostic groups accounted for 94% of total non-CNS solid tumours, in adolescents. Overall incidence rates increased significantly in children up to 1996 with an annual percentage change (APC) of 2.6% (95% CI: 1.7; 3.6). NB and COET showed significant time trend (APCs: 1.4% and 3.8% respectively) while other tumour groups such as RT, STS, BT or GCT had no significant changes over time. A significant increase was present in NB under the age of 5 and in BT and STS in children aged 10-14 years. In adolescents there were significant increases for all tumours combined (APC=2.7; 95% CI: 1.8-3.6) and for STS, GCT and COET (APCs: 3.2%, 4.4% and 3.5% respectively), while other tumour groups such as hepatic tumours, BT or thyroid carcinomas showed a decreasing trend or no increase. Conclusions: Overall, the incidence of the studied cancers in children increased along the period 1983-1996 with no posterior significant rise, while the incidence in adolescents increased significantly over the whole period 1983-2007. Several specific tumour groups showed significant rises or decrements in childhood or adolescence, although the small number of cases precludes showing significant trends or inflexion points

Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations

Cytogenetic analysis of unstimulated short-term bone marrow cell cultures was performed on 280 patients with multiple myeloma and related disorders. In 65% of the cases, an additional short term B-cell stimulated culture was also examined. Chromosomally abnormal clones were found in 31% of the patients, 15% in Waldenström macroglobulinemia. 25% in monoclonal gammopathies, 33% in multiple myeloma, and 50% in plasma cell leukemia. Three primary chromosomal breakpoints were recurrently involved: 14q32, 16q22, and 22q11. Structural rearrangements of chromosome 1 were the most frequent (26% of the abnormal cases), but always as a secondary change. Rearrangements of band 14q32 were found in 22% of the abnormal cases. Among the multiple myeloma patients who showed an abnormal karyotype, 33 (46%) were hyperdiploid, most frequently, with 52-56 chromosomes, 29 patients (40%) were pseudodiploid, and the remaining 12 cases (14%) were hypodiploid. A highly significant relation was observed between the presence of an abnormal karyotype and the following clinical parameters: stage III (P = 0.0001), bone marrow plasma cell infiltration greater than 30% (P = 0.0001), presence of bone lesions (P = 0.0009), and beta 2-microglobulin levels greater than 4 mg/L (P = 0.0001)

Inverse-probability weighting and multiple imputation for evaluating selection bias in the estimation of childhood obesity prevalence using data from electronic health records

Background and objectives: Height and weight data from electronic health records are increasingly being used to estimate the prevalence of childhood obesity. Here, we aim to assess the selection bias due to missing weight and height data from electronic health records in children older than five. Methods: Cohort study of 10,811 children born in Navarra (Spain) between 2002 and 2003, who were still living in this region by December 2016. We examined the differences between measured and non-measured children older than 5 years considering weight-associated variables (sex, rural or urban residence, family income and weight status at 2–5 yrs). These variables were used to calculate stabilized weights for inverse-probability weighting and to conduct multiple imputation for the missing data. We calculated complete data prevalence and adjusted prevalence considering the missing data using inverse-probability weighting and multiple imputation for ages 6 to 14 and group ages 6 to 9 and 10 to 14. Results: For 6–9 years, complete data, inverse-probability weighting and multiple imputation obesity age-adjusted prevalence were 13.18% (95% CI: 12.54–13.85), 13.22% (95% CI: 12.57–13.89) and 13.02% (95% CI: 12.38–13.66) and for 10–14 years 8.61% (95% CI: 8.06–9.18), 8.62% (95% CI: 8.06–9.20) and 8.24% (95% CI: 7.70–8.78), respectively. Conclusions: Ages at which well-child visits are scheduled and for the 6 to 9 and 10 to 14 age groups, weight status estimations are similar using complete data, multiple imputation and inverse-probability weighting. Readily available electronic health record data may be a tool to monitor the weight status in children

Time trends in cancer incidence in Navarra and Zaragoza, spain.

[ES] Objetivo Conocer los cambios que se producen en los patrones de incidencia y mortalidad por cáncer con el paso del tiempo es un elemento básico para su control. En este trabajo se presentan los resultados sobre la evolución temporal de la incidencia de los tumores más importantes en Navarra y Zaragoza. Métodos Se ha utilizado un modelo log-lineal para evaluar el efecto de la edad, el período de diagnóstico y la cohorte de nacimiento en las tendencias de la incidencia de cáncer empleando los datos de los registros de Navarra y Zaragoza. Los resultados se muestran en forma gráfica para los diferentes tumores, en cada registro y sexo. Resultados En hombres, destaca el fuerte aumento de la incidencia en cáncer de pulmón (5% anual), próstata (> 2% anual) y linfomas no hodgkinianos. En mujeres, los incrementos más altos se han producido en linfomas no hodgkinianos con aumentos superiores al 7% anual y en el cáncer de ovario (4% anual). El cáncer de mama en mujeres ha aumentado en ambas provincias (Navarra 3,5% y Zaragoza 0,9%), siendo una parte del incremento en Navarra derivado de una mayor detección de casos. En ambos registros y en los dos sexos se han producido incrementos de la incidencia superiores al 3% anual en cáncer colorrectal, de vejiga y de riñón. Para la mayor parte de los tumores el riesgo de padecer un cáncer se incrementa en las sucesivas generaciones, con la excepción del cáncer de estómago y del cáncer de hígado. Conclusiones El importante incremento de la incidencia de cáncer pone de manifiesto la insuficiencia de las políticas de prevención primaria, la importancia de disponer de datos de incidencia en series prolongadas en el tiempo y la necesidad de aumentar la cobertura poblacional de los registros de cáncer en España. [EN] The knowledge of time-related changes occurring in cancer incidence and mortality is an essential element for cancer control. This paper aims to describe the time trends of the more important cancer sites in Navarra and Zaragoza. The influence of age, diagnosis period and birth cohort on the observed time trend cancer incidence in Navarre and Zaragoza was assessed using a log-linear model. Results are showed graphically, for the different tumour sites by sex and each registry. Among males, a considerable rise in the incidence of lung cancer (5% per year), prostate cancer (> 2% per year) and non-Hodgkin's lymphomas was found. Among females, the highest increases corresponded to non-Hodgkin's lymphomas, with a yearly rise greater than 7%, and ovarian cancer (4% per year). Breast cancer in women increased in both registries (3.5% per year in Navarre and 0.9% per year in Zaragoza), part of the increment in Navarra being explained by a higher case detection rate. Finally, the incidence of colorectal, bladder and kidney cancer rose more than a 3% per year in both registries and sexes. For most types of tumours, cancer risk increased with subsequent generations. The substantial cancer increment observed points out the inefficacy of primary prevention policies, the importance of studying cancer incidence for long time periods and the need to increase the population coverage of Spanish cancer registries.S