Pierwsze dwa momenty oceny wariogramu

In this article we deal with theoretical bases of geostatistic which have employment in research of time series. Let we have stationary random process, defined on R, with expected value equal 0, given covariance function and spectral density. For this process we define variogram function and prove two theorems about variogram estimator property

Progress in the analysis of the even parity configurations of tantalum atom

The experimental work of L. Windholz, G.H. Guthöhrlein and co-workers, concerning observation of the tantalum spectrum, yield many information about new energy levels and hyperfine structure splitting. We contribute the results of the complex parametric studies of the fine- and hyperfine structure of the mentioned element up to second-order of perturbation theory, including the effects of closed shell - open shell excitations. The work has been performed for the systems including 47 even configurations. The values of the radial parameters describing the one- and many-body interactions effects on atomic structure are given. We predicted values of energy levels and their A- and B- hyperfine structure constants, also for experimentally levels not observed up to now

Adoptive cell therapy—harnessing antigen-specific t cells to target solid tumours

In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells as therapeutic tools. Immunotherapy with T cells expressing chimeric antigen receptors (CARs) demonstrated great success in the treatment of haematologic malignancies, whereas adoptive transfer of autologous tumour infiltrating lymphocytes (TILs) proved to be highly effective in metastatic melanoma. These encouraging results initiated many studies where ACT was tested as a treatment for various solid tumours. In this review, we provide an overview of the challenges of T cell-based immunotherapies of solid tumours. We describe alternative approaches for choosing the most efficient T cells for cancer treatment in terms of their tumour-specificity and phenotype. Finally, we present strategies for improvement of anti-tumour potential of T cells, including combination therapies

Observation of Pr+\text{}^{+} Ions in Paul Trap

The first observation of Pr$\text{}^{+}$ ions stored in a Paul trap is reported. Initially the ions were observed by the electronic detection method, and further the laser induced fluorescence, following resonance absorption at a certain optical transition in Pr$\text{}^{+}$ ion, which is excited from the ground state, was recorded. Moreover, fluorescence signal following the excitation from a low-lying metastable state could be detected. The Paul trap system and some other parts of the experimental setup were constructed within the frame of this work and thus are briefly described in the present contribution