Endogenous space in the Net era

Libre Software communities are among the most interesting and advanced socio-economic laboratories on the Net. In terms of directions of Regional Science research, this paper addresses a simple question: “Is the socio-economics of digital nets out of scope for Regional Science, or might the latter expand to a cybergeography of digitally enhanced territories ?” As for most simple questions, answers are neither so obvious nor easy. The authors start drafting one in a positive sense, focussing upon a file rouge running across the paper: endogenous spaces woven by socio-economic processes. The drafted answer declines on an Evolutionary Location Theory formulation, together with two computational modelling views. Keywords: Complex networks, Computational modelling, Economics of Internet, Endogenous spaces, Evolutionary location theory, Free or Libre Software, Path dependence, Positionality.

Diffusion des nouveaux outils de communication dans les entreprises de taille moyenne : une comparaison France/Italie

The paper deals with the diffusion of new communication tools in middle size companies. A survey of about 200 firms, in France and Italy, shows the diffusion of such new tools as private and public Email, EDI, Teleservices and Internet. The traditional threshold effects in the adoption of ICT\u27s seem to disappear, except for the most mature tool, private Email. Industry-specific adoption patterns are significant in most cases, and they show the impact of National Production and Innovation Systems

Caveolae-Mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time

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Quality of life measures in Italian children with atopic dermatitis and their families

<p>Abstract</p> <p>Background</p> <p>The impact of atopic dermatitis (AD) on children's quality of life (QoL) in US and European countries is relatively well known, though rarely evaluated in the Italian population. Moreover, the association between child age and QoL has not been enough investigated, even though few studies detected a worse QoL in youngest AD children. The aim of the study was to evaluate the QoL in an Italian sample of atopic children and their families, also exploring a possible association with child age.</p> <p>Methods</p> <p>60 AD children aged between 1-12 years and their mothers completed specific QoL questionnaires (IDQoL/CDLQI, DFI) and a clinician completed a measure of AD severity (SCORAD).</p> <p>Results</p> <p>AD severity (Objective SCORAD) significantly correlated with QoL measures. Severe AD children showed higher IDQoL/CDLQI and DFI scores compared to mild and moderate AD groups (<it>P </it>= 0.006 and <it>P </it>< 0.0005, respectively), but only DFI scores differed in these last two conditions (<it>P </it>= 0.014). DFI scores negatively correlated with children's age (<it>P </it>= 0.046), but did not differ when considering child age ranges. Multiple linear regression analyses revealed a significant association between Objective SCORAD and QoL measures.</p> <p>Conclusions</p> <p>A strong association between severe AD and poor QoL, both in children and mothers, was found in the Italian sample, in line with the international literature. Family's QoL scores were sensitively related to AD severity, more than the child's QoL, emphasising that the disease has a deep impact on the family. A significant association between age and QoL was only partially found and needs further investigation.</p

Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins.

The transactivator protein of human immunodeficiency virus type 1 Tat has the unique property of mediating the delivery of large protein cargoes into the cells when present in the extracellular milieu. Here we show that Tat fusion proteins are internalized by the cells through a temperature-dependent endocytic pathway that originates from cell membrane lipid rafts and follows caveolar endocytosis. These conclusions are supported by the study of the slow kinetics of the internalization of Tat endosomes, by their resistance to nonionic detergents, the colocalization of internalized Tat with markers of caveolar endocytosis, and the impairment of the internalization process by drugs that disrupt lipid rafts or disturb caveolar trafficking. These results are of interest for all those who exploit Tat as a vehicle for transcellular protein delivery

Management of the corpse with suspect, probable or confirmed COVID-19 respiratory infection \u2013 Italian interim recommendations for personnel potentially exposed to material from corpses, including body fluids, in morgue structures and during autopsy practice.

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